162 research outputs found
Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system
The physiological hydroelectrolytic balance and the redox steady state in the kidney are accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Angiotensin II, atrial natriuretic peptide and intrarenal dopamine play a pivotal role in this interactive network. The balance between endogenous antioxidant agents like the renal dopaminergic system and atrial natriuretic peptide, by one side, and the prooxidant effect of the renin angiotensin system, by the other side, contributes to ensuring the normal function of the kidney. Different pathological scenarios, as nephrotic syndrome and hypertension, where renal sodium excretion is altered, are associated with an impaired interaction between two natriuretic systems as the renal dopaminergic system and atrial natriuretic peptide that may be involved in the pathogenesis of renal diseases. The aim of this review is to update and comment the most recent evidences about the intracellular pathways involved in the relationship between endogenous antioxidant agents like the renal dopaminergic system and atrial natriuretic peptide and the prooxidant effect of the renin angiotensin system in the pathogenesis of renal inflammation.Fil: Rukavina Mikusic, Natalia LucĂa. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. Cátedra de FisiopatologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Kravetz, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. Cátedra de FisiopatologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Kouyoumdzian, Nicolás MartĂn. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. Cátedra de FisiopatologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Della Penna, S. L.. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. Cátedra de FisiopatologĂa; ArgentinaFil: Roson, Maria Ines. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. Cátedra de FisiopatologĂa; ArgentinaFil: Fernandez, Belisario Enrique. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. Cátedra de FisiopatologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Choi, Marcelo Roberto. Universidad de Buenos Aires. Facultad de Farmacia y BioquĂmica. Departamento de Ciencias BiolĂłgicas. Cátedra de FisiopatologĂa; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; Argentin
Continuous measurement of global difference coupling using a phase-locked-loop tune meter in the Relativistic Heavy Ion Collider
We present a new technique to continuously measure and compensate the global difference coupling coefficient through the continuous measurements of eigenmode projection parameters, using a high resolution phase-locked-loop tune meter. First, four eigenmode projection parameters are defined as the observables for weak difference coupling. Then, their analytical expressions are obtained using the strict matrix treatment and the Hamiltonian perturbation theory of linear coupling. From these parameters, the complex global coupling coefficient can be fully determined and compensated. This method was successfully demonstrated in the Relativistic Heavy Ion Collider (RHIC) 2006 run
Asymmetric Organocatalysis Accelerated via Self-Assembled Minimal Structures
Self-assembling minimalistic peptides embedded with an organocatalytic moiety were designed. By controlling the formation of fibrils via external intervention, it was shown that the activation is accelerated when the organocatalyst is in its supramolecular state. The effect of the accelerated catalysis was demonstrated in a Michael benchmark reaction
Simultaneous tune and coupling feedback in the Relativistic Heavy Ion Collider, and possible implications for the Large Hadron Collider commissioning
Simultaneous tune and coupling feedback were successfully implemented during RHIC run 6. In this paper we describe the measurement and control hardware and software used to accomplish this, present some of the results, discuss areas that require further investigation, and finally offer a few comments on possible implications of these results for LHC commissioning
Fast room temperature very low field-magnetic resonance imaging system compatible with MagnetoEncephaloGraphy environment
In recent years, ultra-low field (ULF)-MRI is being given more and more attention, due to the possibility of integrating ULF-MRI and Magnetoencephalography (MEG) in the same device. Despite the signal-to-noise ratio (SNR) reduction, there are several advantages to operating at ULF, including increased tissue contrast, reduced cost and weight of the scanners, the potential to image patients that are not compatible with clinical scanners, and the opportunity to integrate different imaging modalities. The majority of ULF-MRI systems are based, until now, on magnetic field pulsed techniques for increasing SNR, using SQUID based detectors with Larmor frequencies in the kHz range. Although promising results were recently obtained with such systems, it is an open question whether similar SNR and reduced acquisition time can be achieved with simpler devices. In this work a room-temperature, MEG-compatible very-low field (VLF)-MRI device working in the range of several hundred kHz without sample pre-polarization is presented. This preserves many advantages of ULF-MRI, but for equivalent imaging conditions and SNR we achieve reduced imaging time based on preliminary results using phantoms and ex-vivo rabbits heads
Dorsal horn-enriched genes identified by DNA microarray, in situ hybridization and immunohistochemistry
BACKGROUND: Neurons in the dorsal spinal cord play important roles in nociception and pain. These neurons receive input from peripheral sensory neurons and then transmit the signals to the brain, as well as receive and integrate descending control signals from the brain. Many molecules important for pain transmission have been demonstrated to be localized to the dorsal horn of the spinal cord. Further understanding of the molecular interactions and signaling pathways in the dorsal horn neurons will require a better knowledge of the molecular neuroanatomy in the dorsal spinal cord. RESULTS: A large scale screening was conducted for genes with enriched expression in the dorsal spinal cord using DNA microarray and quantitative real-time PCR. In addition to genes known to be specifically expressed in the dorsal spinal cord, other neuropeptides, receptors, ion channels, and signaling molecules were also found enriched in the dorsal spinal cord. In situ hybridization and immunohistochemistry revealed the cellular expression of a subset of these genes. The regulation of a subset of the genes was also studied in the spinal nerve ligation (SNL) neuropathic pain model. In general, we found that the genes that are enriched in the dorsal spinal cord were not among those found to be up-regulated in the spinal nerve ligation model of neuropathic pain. This study also provides a level of validation of the use of DNA microarrays in conjunction with our novel analysis algorithm (SAFER) for the identification of differences in gene expression. CONCLUSION: This study identified molecules that are enriched in the dorsal horn of the spinal cord and provided a molecular neuroanatomy in the spinal cord, which will aid in the understanding of the molecular mechanisms important in nociception and pain
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Reduction of beta* and increase of luminosity at RHIC
The reduction of {beta}* beyond the 1m design value at RHIC has been consistently achieved over the last 6 years of RHIC operations, resulting in an increase of luminosity for different running modes and species. During the recent 2007-08 deuteron-gold run the reduction to 0.70 from the design 1m achieved a 30% increase in delivered luminosity. The key ingredients allowing the reduction have been the capability of efficiently developing ramps with tune and coupling feedback, orbit corrections on the ramp, and collimation, to minimize beam losses in the final focus triplets, the main aperture limitations for the collision optics. We will describe the operational strategy used to reduce the {beta}*, at first squeezing the beam at store, to test feasibility, followed by the operationally preferred option of squeezing the beam during acceleration, and the resulting luminosity increase. We will conclude with future plans for the beta squeeze
Platform Dependent Verification: On Engineering Verification Tools for 21st Century
The paper overviews recent developments in platform-dependent explicit-state
LTL model checking.Comment: In Proceedings PDMC 2011, arXiv:1111.006
Rapid spread of complex change: a case study in inpatient palliative care
<p>Abstract</p> <p>Background</p> <p>Based on positive findings from a randomized controlled trial, Kaiser Permanente's national executive leadership group set an expectation that all Kaiser Permanente and partner hospitals would implement a consultative model of interdisciplinary, inpatient-based palliative care (IPC). Within one year, the number of IPC consultations program-wide increased almost tenfold from baseline, and the number of teams nearly doubled. We report here results from a qualitative evaluation of the IPC initiative after a year of implementation; our purpose was to understand factors supporting or impeding the rapid and consistent spread of a complex program.</p> <p>Methods</p> <p>Quality improvement study using a case study design and qualitative analysis of in-depth semi-structured interviews with 36 national, regional, and local leaders.</p> <p>Results</p> <p>Compelling evidence of impacts on patient satisfaction and quality of care generated 'pull' among adopters, expressed as a remarkably high degree of conviction about the value of the model. Broad leadership agreement gave rise to sponsorship and support that permeated the organization. A robust social network promoted knowledge exchange and built on an existing network with a strong interest in palliative care. Resource constraints, pre-existing programs of a different model, and ambiguous accountability for implementation impeded spread.</p> <p>Conclusions</p> <p>A complex, hospital-based, interdisciplinary intervention in a large health care organization spread rapidly due to a synergy between organizational 'push' strategies and grassroots-level pull. The combination of push and pull may be especially important when the organizational context or the practice to be spread is complex.</p
Response to Comment on “Estimating the reproducibility of psychological science”
Gilbert et al. conclude that evidence from the Open Science Collaboration's Reproducibility Project: Psychology indicates high reproducibility, given the study methodology. Their very optimistic assessment is limited by statistical misconceptions and by causal inferences from selectively interpreted, correlational data. Using the Reproducibility Project: Psychology data, both optimistic and pessimistic conclusions about reproducibility are possible, and neither are yet warranted.status: publishe
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