Numerical analysis of formability and failure in tube inversion using i-Form

El trabajo se basa en un análisis numérico de tubos de Aluminio AA6063-T6 deformados con punzones de diferentes radios para el proceso de inversión. El fin principal de este trabajo consiste en determinar cuáles son los radios límites para este proceso, aumentando así el estado del arte. El trabajo inicia con un análisis de todo lo investigado hasta ahora. Posteriormente se explica cómo ha sido modelado todo el proceso y cómo se extraen los diferentes resultados en el programa empleado: i-Form. El proceso se modela para que se lleve a cabo con una velocidad constante. Una vez hecho esto, se pasa a exponer todos los resultados obtenidos comparándolos con resultados experimentales calculados en investigaciones anteriores, validando así los datos numéricos. Los resultados que se analizan son la fuerza y las deformaciones y, una vez validados, el daño dúctil y el espacio de la triaxialidad. Todo esto permite definir con bastante seguridad los radios límites para llevar a cabo el proceso de inversión de forma satsifactoria tanto para radios pequeños como para radios grandes.The work is based on a numerical analysis of aluminum tubes AA6063-T6 deformed with punches of different radius for the inversion process. The main purpose of this work is to determine what are the radii limits for this process, increasing the state of the art. The work begins with an analysis of everything investigated so far. Subsequently, it explains how the whole process has been modeled and how the different results are extracted in the program used: i-Form. The process is modeled to be carried out with a constant speed. Once this is done, all the results obtained are presented, comparing them with experimental results calculated in previous investigations, validating the numerical data. The results that are analyzed are the force and the strains and, once validated, the ductile damage and the space of triaxiality. All this allows to define with certainty the radii limits to carry out the inversion process in a satsifactory way for both small radios and large radios.Universidad de Sevilla. Máster en Ingeniería Industria

Improving long line stability by integrating renewables using static synchronous generators

Postprint (author's final draft

Synchronous power controller merits for dynamic stability improvement in long line by renewables

Postprint (author's final draft

Supporting phase stability on interconnected grids by synchronous renewable virtual power plants

Rapid growing on the power level of renewable generation units leads to that using more adaptable and flexible control techniques in this units becomes more important for grid operators. In this paper, after introducing Renewable Static Synchronous Generation Units (RSSGU) as units with flexible dynamics capability, forming of renewable Virtual Power Plants based on this RSSGUs (VPP-SSG) is suggested as a solution for overcoming phase stability challenges on interconnected generation areas. Based on the dynamic modeling and small signal analysis, an algorithm is presented for the dynamic designing of VPP-SSGs aims to provide supporting damping for both local and interarea oscillatory modes. Modal analysis and time domain study on active powers inside of generation areas and tie lines on two area system using Simulink confirms that these type of VPP-SSGs can support phase stability on power grid with interconnected generation areasPeer ReviewedPostprint (author's final draft

Producción de ovino de carne en medio semiárido

Unpublishe

Una Experiencia de unificación de asignaturas para desplegar PBL (y las quejas que originó)

En esta ponencia se describen los aspectos esenciales de una experiencia de unificación de parejas de asignaturas con el objetivo de crear un escenario más adecuado para el despliegue de Aprendizaje Basado en Proyectos. Como guía para el repaso de esos aspectos esenciales se utiliza una carta que elaboraron los estudiantes de la primera edición para protestar por el funcionamiento de las asignaturas. El análisis de las quejas de los estudiantes puede ser de mucha utilidad para otros que se planeen retos similares.SUMMARY -- This paper describes the key aspects of an experience of unification of pairs of subjects in order to create a more suitable scenario for deployment of Project Based Learning. To guide the review of these essential aspects we use a letter that students from the first edition wrote to protest against the organization of the subjects. The analysis of the complaints of the students can be very helpful for others who are planning similar innovations

Phase II clinical trial of nab-paclitaxel plus gemcitabine in elderly patients with previously untreated locally advanced or metastatic pancreatic adenocarcinoma: the BIBABRAX study

[Purpose] To evaluate the health-related quality of life (HRQoL), global health status (GHS), and deterioration-free survival of an elderly population (> 70 years) with unresectable locally advanced (LAPC) or metastatic pancreatic cancer (mPC) treated with nab-paclitaxel in combination with gemcitabine.[Methods] In this open-label, single-arm, multicenter, phase II trial, patients received 4-week cycles of intravenous (i.v.) nab-paclitaxel at a dose of 125 mg/m2, followed by i.v. injections of gemcitabine at a dose of 1000 mg/m2 on days 1, 8 and 15 until disease progression or unacceptable toxicity was observed. The primary outcome was the HRQoL (deterioration-free rate at 3 months as evaluated with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30.[Results] Eighty patients (median age: 74.6 years) were enrolled (56 with mPC, 24 with LAPC). The percentage of patients who had not experienced deterioration at 3 months was 54.3% (95% CI 41.6–67.0%). The median (interquartile range) time until definite deterioration was 1.6 (1.1–3.7) months. The objective response rate and clinical benefit rate were achieved by 11 (13.8%, 95% CI 6.2–21.3%) and 54 patients (67.5%, 95% CI 57.2–77.8%), respectively. The median overall survival was 9.2 months (95% CI 6.9–11.5), and the median progression-free survival was 7.2 months (95% CI 5.8–8.5). Only fatigue and neutropenia demonstrated a grade 3–4 toxicity incidence > 20%.[Conclusions] Our study confirms the clinical benefit of the combination of nab-paclitaxel and gemcitabine in an elderly population with pancreatic cancer in terms of improved survival and clinical response. However, we were unable to confirm a benefit in terms of quality-of-life.The BIBABRAX study was funded by Celgene. Medical writing assistance in the preparation of this paper was provided by Apices with financial support from Celgene.Peer reviewe

Antiretroviral therapy duration and immunometabolic state determine efficacy of ex vivo dendritic cell-based treatment restoring functional HIV-specific CD8+ T cells in people living with HIV.

Dysfunction of CD8+ T cells in people living with HIV-1 (PLWH) receiving anti-retroviral therapy (ART) has restricted the efficacy of dendritic cell (DC)-based immunotherapies against HIV-1. Heterogeneous immune exhaustion and metabolic states of CD8+ T cells might differentially associate with dysfunction. However, specific parameters associated to functional restoration of CD8+ T cells after DC treatment have not been investigated. We studied association of restoration of functional HIV-1-specific CD8+ T cell responses after stimulation with Gag-adjuvant-primed DC with ART duration, exhaustion, metabolic and memory cell subsets profiles. HIV-1-specific CD8+ T cell responses from a larger proportion of PLWH on long-term ART (more than 10 years; LT-ARTp) improved polyfunctionality and capacity to eliminate autologous p24+ infected CD4+ T cells in vitro. In contrast, functional improvement of CD8+ T cells from PLWH on short-term ART (less than a decade; ST-ARTp) after DC treatment was limited. This was associated with lower frequencies of central memory CD8+ T cells, increased co-expression of PD1 and TIGIT and reduced mitochondrial respiration and glycolysis induction upon TCR activation. In contrast, CD8+ T cells from LT-ARTp showed increased frequencies of TIM3+ PD1- cells and preserved induction of glycolysis. Treatment of dysfunctional CD8+ T cells from ST-ARTp with combined anti-PD1 and anti-TIGIT antibodies plus a glycolysis promoting drug restored their ability to eliminate infected CD4+ T cells. Together, our study identifies specific immunometabolic parameters for different PLWH subgroups potentially useful for future personalized DC-based HIV-1 vaccines. NIH (R21AI140930), MINECO/FEDER RETOS (RTI2018-097485-A-I00) and CIBERINF grants.NIH (R21AI140930), MINECO/FEDER RETOS (RTI2018-097485-A-I00) and CIBERINF grants. We would like to thank the NIH AIDS Reagent Pro- gram, Division of AIDS, NIAID, NIH for providing HIV-1 PTE Gag Peptide Pool from NIAID, DAIDS (cat #11057) for the study. We would also like to thank Alvaro Serrano Navarro, for his help on adapting the lin- ear mixed model previously described by Martin- C ofreces N. et al83 to our data. Graphical schematic rep- resentations were created with BioRender.com. EMG was supported by the NIH R21 program (R21AI140930), the Ramón y Cajal Program (RYC2018- 024374-I), the MINECO/FEDER RETOS program (RTI2018-097485-A-I00), by Comunidad de Madrid Talento Program (2017-T1/BMD-5396) and by Gilead becas de investigaci on (GLD19/00168). EMG and IDS are supported by Centro de Investigación Biomédica en Red (CIBERINF) de Enfermedades Infecciosas (CB21/ 13/00107). MCM was supported by NIH R21 program (R21AI140930), “La Caixa Banking Foundation (H20- 00218) and Gilead becas de investigaci on (GLD19/ 00168). MJB is supported by the Miguel Servet program funded by the Spanish Health Institute Carlos III (CP17/00179), the MINECO/FEDER RETOS program (RTI2018-101082-B-100), and Fundació La Marat o TV3 (201805-10FMTV3). EMG and MJB are both funded by “La Caixa Banking Foundation (H20-00218) and by REDINCOV grant from Fundació La Marat o TV3. FSM was supported by SAF2017-82886-R and PDI-2020- 120412RB-I00 grants from the Ministerio de Ciencia e Innovaci on, and HR17-00016 grant from “La Caixa Banking Foundation. HF was funded by PI21/01583 grant from Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III. MJC was supported by PID2019- 104406RB-I00 from Ministerio de Ciencia e Innovación. ISC was funded by the CM21/00157 Rio- Hortega grant. IT was supported by grant for the pro- motion of research studies master-UAM 2021.S

Una experiencia de unificación de asignaturas para desplegar PBL (y las quejas que originó)

En este artículo se describen los aspectos esenciales de una experiencia de unificación de parejas de asignaturas con el objetivo de crear un escenario más adecuado para el despliegue de Aprendizaje Basado en Proyectos. Como guía para el repaso de esos aspectos esenciales se utiliza una carta que elaboraron los estudiantes de la primera edición para protestar por el funcionamiento de las asignaturas. El análisis de las quejas de los estudiantes puede ser de mucha utilidad para otros que se planeen retos similares.Peer ReviewedPostprint (published version