The use of bisphosphonates in the management of bone involvement from solid tumours and haematological malignancies - a European survey.

Bone metastases in patients with solid tumours (ST) and bone lesions in patients with haematological malignancies (HM) are common. Associated skeletal-related events (SREs) cause severe pain, reduced quality of life and place a burden on health care resources. Bone-targeted agents can reduce the risk of SREs. We evaluated the management of bone metastasis/lesions in five European countries (France, Germany, Italy, Spain and the UK) by an observational chart audit. In total, 881 physicians completed brief questionnaires on 17 193 patients during the observation period, and detailed questionnaires for a further 9303 individuals. Patient cases were weighted according to the probability of inclusion. Although a large proportion of patients with bone metastases/lesions were receiving bisphosphonates, many had their treatment stopped (ST, 19%; HM, 36%) or will never be treated (ST, 18%; HM, 13%). The results were generally similar across the countries, although German patients were more likely to have asymptomatic bone lesions detected during routine imaging. In conclusion, many patients who could benefit from bone-targeted agents do not receive bisphosphonates and many have their treatment stopped when they could benefit from continued treatment. Developing treatment guidelines, educating physicians and increasing the availability of new agents could benefit patients and reduce costs

New Perspectives on Political economy and Its History

A renowned list of scholars articulate and respond to this vision through a series of essays, leading to an advocacy of pluralism and critical thinking in political economy. The book is split into five parts, opening with a section on new topics for the history of economic thought including new perspectives in gender studies and an illustration of the fecundity of the link with economic history. This is followed by sections that address relevant perspectives on the Classical approach to distribution and accumulation, Ricardo, interpretation of Sraffa and the legacy of Keynes. This book will appeal to students interested in reforming economics, as well as academics and economists interested in political economy and the history of economic thought

Introduction

In contrast to the reorientation of political economy implemented by Keynes with his General Theory less than seven years after the 1929 Wall Street crash, no substantial change in the mainstream approach to economics can be detected twelve years after the collapse of Lehman Brothers. The same Dynamic Stochastic General Equilibrium (DSGE) model which had been unable to anticipate the crisis still rules research, teaching and economic policy, only marginally modified to take account of the most obvious flaws of the economic system. In this intellectual environment, going back to past authors may be of some help, not to fuel nostalgia for times gone by but to explore modern economic issues along new perspectives—in short to build theory and understand facts. This is the task of the history of economic thought, when it is not understood as a graveyard for respected albeit no longer read authors but as a living corpus of debates on the same old issues shrunk and distorted by the present mainstream

On the coupling between magnetic field and nutation in a numerical integration approach

Nutation amplitudes are computed in a displacement field approach that incorporates the influence of a prescribed magnetic field inside the Earth's core. The existence of relative nutational motions between the liquid core and its surrounding solid parts induces a shearing of the magnetic field. An incremental magnetic field is then created, which in return perturbs the nutations themselves. This problem has already been addressed within a nutation model computed from an angular momentum budget approach. Here we incorporate the magnetic field influence directly in the motion equation and in the boundary conditions used in precise nutation theory, and a new strategy to compute nutations is established. As in previous studies, we assume that the root-mean-square of the radial magnetic field amplitude at the core-mantle boundary is 6.9 Gauss, that the magnetic diffusivity at the bottom of the mantle and in the fluid outer core side is 1.6 m 2/s, and that the thickness of the conductive layer at the bottom of the mantle is 200 m. The Coriolis force is included in this work. The results show that the free core nutation period decreases by 0.38 days, and that the out-of-phase (in-phase) amplitudes of the retrograde 18.6 year and the retrograde annual nutations increase (decrease) by 20 and 39 μas, respectively. Comparisons of these results with previous studies are made, and discussions are also presented on the contribution of Coriolis force and the prescribed magnetic field on the coupling constants

Dialogue entre les parties prenantes : un levier dans la mutation de la science chahutée par l'anthropocène

Science & You 2021 : Create the Future, Metz, FRA, 16-/11/2021 - 19/11/202