Effect of a non-dieting lifestyle randomised control trial on psychological well-being and weight management in morbidly obese pre-menopausal women.

Objective This study examined the effects of a non-dieting lifestyle intervention approach for morbidly obese women designed in the framework of the self-determination theory (SDT) and Health at Every Size on weight maintenance and psychological functioning. Participants and design Predominantly white (97%), morbidly obese (BMI ≥ 35 kg m-2 with at least one co-morbid condition or a BMI ≥ 40 kg m-2) pre-menopausal women (N = 62), aged between 24 and 55 years were initially randomly assigned to 12 weeks of lifestyle intervention (IIG) or delayed start control group (DSCG). The program consisted of 3 months intensive lifestyle intervention followed by 9 month maintenance phase. The DSCG group commenced the program after 3 months. Results and conclusions Initially, the IIG showed a significant decrease in body weight (baseline to end of the RCT phase) compared with a significant increase in the DSCG group. However, no significant changes in weight status were evident in either group at 12 months compared with baseline. The 3-month intensive intervention resulted in significantly improved psychological functioning in both groups, which were maintained at 12 months. The study provides additional support for a non-dieting, theory-based, lifestyle approach to weight management and psychological well-being among morbidly obese females

Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders

Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 novel). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (e.g., GRIA1, GRM8, CACNA1E ), developmental, axon guidance, and transcription factors (e.g., FOXP2, EFNA5, DCC ), synaptic structure and function genes (e.g., PCLO, NCAM1, PDE4B ), and endocrine or immune regulators (e.g., ESR1, TRAF3, TANK ). Additional top genes influence stress, immune, fear, and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation

Sloan Valve Company (sequence unknown), IPRO 306 - Deliverables: 306_redacted

Sloan Valve manufactures and distributes commercial valves and plumbing fixtures globally. The IPRO team will work to improve the 'procure to pay' process and also assist in the development of a new warehouse management module.Sponsorship: Sloan Valve CompanyDeliverables for IPRO 306: Sloan Valve for the fall 2009 semester

Sloan Valve Company (sequence unknown), IPRO 306 - Deliverables: IPRO 306 Midterm Presentation F09

Sloan Valve manufactures and distributes commercial valves and plumbing fixtures globally. The IPRO team will work to improve the 'procure to pay' process and also assist in the development of a new warehouse management module.Sponsorship: Sloan Valve CompanyDeliverables for IPRO 306: Sloan Valve for the fall 2009 semester

Sloan Valve Company (sequence unknown), IPRO 306 - Deliverables: IPRO 306 Poster F09

Sloan Valve manufactures and distributes commercial valves and plumbing fixtures globally. The IPRO team will work to improve the 'procure to pay' process and also assist in the development of a new warehouse management module.Sponsorship: Sloan Valve CompanyDeliverables for IPRO 306: Sloan Valve for the fall 2009 semester

Sloan Valve Company (sequence unknown), IPRO 306 - Deliverables

Sloan Valve manufactures and distributes commercial valves and plumbing fixtures globally. The IPRO team will work to improve the 'procure to pay' process and also assist in the development of a new warehouse management module.Sponsorship: Sloan Valve CompanyDeliverables for IPRO 306: Sloan Valve for the fall 2009 semester

Sloan Valve Company (sequence unknown), IPRO 306 - Deliverables: IPRO 306 IPRO Day Presentation F09

Sloan Valve manufactures and distributes commercial valves and plumbing fixtures globally. The IPRO team will work to improve the 'procure to pay' process and also assist in the development of a new warehouse management module.Sponsorship: Sloan Valve CompanyDeliverables for IPRO 306: Sloan Valve for the fall 2009 semester

Sloan Valve Company (sequence unknown), IPRO 306 - Deliverables: IPRO 306 Abstract F09

Sloan Valve manufactures and distributes commercial valves and plumbing fixtures globally. The IPRO team will work to improve the 'procure to pay' process and also assist in the development of a new warehouse management module.Sponsorship: Sloan Valve CompanyDeliverables for IPRO 306: Sloan Valve for the fall 2009 semester

Technology and Business Innovations to Improve Operations (Semester Unknown) IPRO 306: TechnologyAndBusinessInnovationsToImproveOperationsIPRO306ProjectPlanF09_redacted

The IPRO 306 team is tasked with assisting a major plumbing manufacturer, Sloan Valve, in utilizing current technology to create efficiencies within its current operations. Due to the scope of the project and the desire of the team to produce the greatest impact on Sloan Valve, IPRO 306 will be involved with 2 projects during the fall of 2009.Sponsorship: Steven Rodgers, Sloan ValveDeliverable

Technology and Business Innovations to Improve Operations (Semester Unknown) IPRO 306: TechnologyAndBusinessInnovationsToImproveOperationsIPRO306AbstractF09

The IPRO 306 team is tasked with assisting a major plumbing manufacturer, Sloan Valve, in utilizing current technology to create efficiencies within its current operations. Due to the scope of the project and the desire of the team to produce the greatest impact on Sloan Valve, IPRO 306 will be involved with 2 projects during the fall of 2009.Sponsorship: Steven Rodgers, Sloan ValveDeliverable