The U.S. Invasion of the Dominican Republic: From Cooperation to Conquest

This paper explores the political and military relationship between the U.S. and the Dominican Republic from the Eisenhower administration to the Johnson administration’s invasion in 1965. The U.S. intervention in the Dominican Republic was a military operation that had been planned and prepared for by administrations prior and not simply a reactive decision to prevent a Communist takeover. Analysis of multiple administrations places the invasion of the Dominican Republic in a larger context of U.S. – Dominican relations. The U.S.’s desire to dominate military and political aspects of the Dominican Republic is consistent with U.S. Cold War Latin American policy

The Optimization of MitoNEET Synthesis, Purification and Mutation Stability in the [2Fe-2S] Cluster

MitoNEET, a mitochondrial membrane protein with an unsymmetrical Fe-S cluster coordination, was compared to similar proteins within the Rieske and Ferredoxin families. Point mutations were introduced via site-directed mutagenesis to induce stability, greater retention of the cluster, and to uncover structural limitations of the protein. Mutations were made within the cluster coordination and within the hydrophobic core of the protein. Some of the cluster mutations displayed a natural affinity for nickel during immobilized metal-ion affinity chromatography. It is possible that these mutations aid in the formation of a chelate when exposed to nickel. Spectroscopic monitoring of changes in cluster stability under low pH conditions was used to compare cluster retention across mutations. Some of the cluster mutants displayed a significant increase in stability versus wild type and other mutated forms of the protein. The hydrophobic mutations were found to push structural limitations of the protein by disrupting the hydrophobic core, even in the presence of the stabilizing cluster mutations. These mutation results would benefit from further structural research

Body Mass Index Change as a Predictor of Biometric Changes following an Intensive Lifestyle Modification Program

The initial benefits of lifestyle modification programs such as reduction in chronic and cardiovascular diseases (CVD) risk factors have been well documented. However, such positive effects may deteriorate over time following relapse into inactivity. Timely detection of weight regain leading to the deterioration of the accrued benefits could trigger early resumption of intensive lifestyle intervention. To date, no known cost-effective, noninvasive approach for monitoring long-term outcomes has yet been established. The purpose of this study was to determine if body mass index (BMI) change predicted changes in other CVD biometric markers during an intensive lifestyle modification program. This study was an observational, retrospective review of records of participants from the Complete Health Improvement Program (CHIP). Biomarker changes of participants in this community-based Intensive Therapeutic Lifestyle Modification Program (ITLMP) offered in Athens, Ohio, a rural Appalachian college town, between April 2011 and June 2017 were reviewed retrospectively. BMI, heart rate (Pulse), systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting blood levels of total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), and glucose (FBS) were monitored before and after program completion. Data were analyzed using a multivariate general linear model. The sample analyzed consisted of 620 participants (mean age of 52.3±13.0 years, 74.5% female). Controlling for age and gender, BMI change significantly predicted 5 out of the 8 biomarker changes measured [Wilk’s λ = 0.939, F(8,526) = 4.29, p <.0001]. Specifically, a 1-point BMI decrease was associated with 4.4 units decrease in TC, 3.2 units in LDL, 5.3 units in TG, 2 units in SBP, and 1 unit in DBP (all p values < .05). These results suggest that change in BMI may be a useful predictor of change in other CVD biomarkers’ outcomes during and after an ITLMP participation. Tracking BMI, therefore, could serve as a proxy measure for identifying regressing biomarker changes following participation in an ITLMP leading to a timelier reassessment and intervention. Future studies evaluating the value of BMI as a surrogate for highlighting overall cardiovascular health are warranted

Correction to Diesel Surrogate Fuels for Engine Testing and Chemical-Kinetic Modeling: Compositions and Properties

Correction to Diesel Surrogate Fuels for Engine Testing and Chemical-Kinetic Modeling: Compositions and Propertie