32 research outputs found

    An analysis of the vertical structure equation for arbitrary thermal profiles

    Get PDF
    The vertical structure equation is a singular Sturm-Liouville problem whose eigenfunctions describe the vertical dependence of the normal modes of the primitive equations linearized about a given thermal profile. The eigenvalues give the equivalent depths of the modes. The spectrum of the vertical structure equation and the appropriateness of various upper boundary conditions, both for arbitrary thermal profiles were studied. The results depend critically upon whether or not the thermal profile is such that the basic state atmosphere is bounded. In the case of a bounded atmosphere it is shown that the spectrum is always totally discrete, regardless of details of the thermal profile. For the barotropic equivalent depth, which corresponds to the lowest eigen value, upper and lower bounds which depend only on the surface temperature and the atmosphere height were obtained. All eigenfunctions are bounded, but always have unbounded first derivatives. It was proved that the commonly invoked upper boundary condition that vertical velocity must vanish as pressure tends to zero, as well as a number of alternative conditions, is well posed. It was concluded that the vertical structure equation always has a totally discrete spectrum under the assumptions implicit in the primitive equations

    Data Assimilation in the Presence of Forecast Bias: The GEOS Moisture Analysis

    Get PDF

    Atmospheric Reanalyses-Recent Progress and Prospects for the Future. A Report from a Technical Workshop, April 2010

    Get PDF
    In April 2010, developers representing each of the major reanalysis centers met at Goddard Space Flight Center to discuss technical issues - system advances and lessons learned - associated with recent and ongoing atmospheric reanalyses and plans for the future. The meeting included overviews of each center s development efforts, a discussion of the issues in observations, models and data assimilation, and, finally, identification of priorities for future directions and potential areas of collaboration. This report summarizes the deliberations and recommendations from the meeting as well as some advances since the workshop

    Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

    Get PDF
    Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie

    Data Assimilation in the Presence of Forecast Bias: the GEOS Moisture Analysis

    No full text
    We describe the application of the unbiased sequential analysis algorithm developed by Dee and da Silva (1998) to the GEOS moisture analysis. The algorithm estimates the slowly varying, systematic component of model error from rawinsonde observations and adjusts the first-guess moisture field accordingly. Results of two seasonal data assimilation cycles show that moisture analysis bias is almost completely eliminated in all observed regions. The improved analyses cause a sizable reduction in the 6h-forecast bias and a marginal improvement in the error standard deviations. 1 Introduction Hidden beneath the computational complexities of atmospheric data assimilation systems lies a multitude of assumptions about the errors associated with observing and predicting atmospheric fields. Most of these assumptions are there for practical reasons, either because there is not enough information to remove them, or because they result in critical computational simplifications. Some, however, are ..

    On-line Estimation of Error Covariance Parameters for Atmospheric Data Assimilation

    Full text link

    Simplification of the Kalman Filter for Meteorological Data Assimilation

    No full text
    We propose a new statistical data assimilation method that is based on a simplification of the Kalman filter equations. The forecast error covariance evolution is approximated by simply advecting the mass error covariance field, by deriving the remaining covariances geostrophically, and by accounting for external model error forcing only at the end of each forecast cycle. This greatly reduces the cost of the forecast error covariance computation, which is the central and most expensive aspect of the Kalman filter algorithm. In simulations with a linear, one-dimensional shallow-water model and artificially generated data, the performance of the simplified filter is compared with that of the Kalman filter and the optimal interpolation (OI) method. These experiments are designed to isolate the effect of simplifying the forecast error covariance evolution. The simplified filter produces analyses that are nearly optimal, and represents a significant improvement over OI. ae 1 Introduction ..

    Prescribed Solution Forcing Method for Model Verification

    No full text
    This paper describes a method for verifying the consistency and order of accuracy of a numerical implementation of a pde-model. We present an application example to a 3D hydrodynamic flow model. The general idea behind PSF By means of the PSF technique it is possible to thoroughly test the quality of a numerical approximation to a given mathematical model, by prescribing an analytical test solution to the model equations and solving the appropriate inhomogeneous version of the model which the test solution exactly satisfies. Suppose that the mathematical model is given by @U @t +D(U) = 0 (1) where U = U(x; t) is a vector function of unknown dependent variables, and D is a spatial differential operator defined on the model domain\Omega \Theta [t 0 ; T ]. The model implementation which is to be validated numerically solves Eq. (1) subject to initial and boundary conditions U = U 0 (x) at t = t 0 (2) B(U) = 0 for x 2 @\Omega ; t t 0 (3) where @\Omega is the boundary of the spat..
    corecore