Damnatio memoriae: On Deleting the East from Western History

The story we read in books about the Renaissance tells us that Petrarch and Poggio rediscovered the books of antiquity that had been copied for centuries in medieval abbeys. The re-introduction of Greek science and philosophy, however, began in the twelfth century but occurred mainly in the thirteenth century. These works were first translated into Syriac and Arabic in the eighth and ninth centuries and stored in the House of Wisdom in Baghdad. There they were read, used, and commented on by Arab philosophers, of whom the most famous was Averroes (1126–1198), who lived in Cordoba. The translation of his commentaries on Aristotle changed the European philosophical scene profoundly. Averroes, who also had a philosophy of his own, had followers in Latin Europe until the sixteenth century. His work was well-known and he appeared in histories of philosophy until the middle of the nineteenth century, when the Arabs were pushed out of the history books. One reason was the invention of the concept of the Renaissance

The daily relation between parental rejection and emotional eating in youngsters : a diary study

KEY POINTS Cross-sectional survey studies have demonstrated significant associations between parental rejection and peer rejection on the one hand and disturbed eating in youngsters, like emotional eating, on the other hand. In this study, we wanted to expand our knowledge on these relationships by investigating the daily fluctuations in these variables. Youngsters completed a 7-day diary to assess daily parental rejection, peer rejection and emotional eating. Using multilevel analyses, our results showed that daily variations in parental rejection were related to daily variations in emotional eating of the youngsters. This highlights the importance of addressing the parent-child relationship in interventions for emotional eating in youngsters.Background: This study investigated the daily relation between parental rejection and peer rejection on the one hand and emotional eating in youngsters on the other hand.Methods: Participants (N = 55) between the ages of 11 and 15 years completed a 7-day diary. A multilevel design was used to examine day-to-day within-person relationships between parental and peer rejection (measured by CHS) and emotional eating (measured by DEBQ-C) of youngsters.Results: The results showed that daily variations in parental rejection were related to daily variations in emotional eating of the youngsters. Daily peer rejection was only marginally significantly related to the emotional eating of the youngsters.Conclusions: These results indicate that especially parental rejection, and to a lesser extent peer rejection, are associated with the emotional eating of youngsters. The findings highlight the importance of addressing the parent-child relationship in interventions for emotional eating in youngsters

WAVELET BASED FUNCTIONAL MODELS FOR TRANSCRIPTOME ANALYSIS WITH TILING ARRAYS

For a better understanding of the biology of an organism a complete description is needed of all regions of the genome that are actively transcribed. Tiling arrays can be used for this purpose. Such arrays allow the discovery of novel transcripts and the assessment of differential expression between two or more experimental conditions such as genotype, treatment, tissue, etc. Much of the initial methodological efforts were designed for transcript discovery, while more recent developments also focus on differential expression. To our knowledge no methods for tiling arrays are described in the literature that can both assess transcript discovery and identify differentially expressed transcripts, simultaneously. The wavelet based functional model developed in this paper is designed to fill this methodological void. As opposed to existing methods, our statistical framework also permits a natural integration of preprocessing into the standard statistical analysis flow of tiling array data. We use Johnson transformations, which are based on cumulants, for computing false discovery rates (FDRs) and Bayesian credibility intervals for the estimates of the effect functions within the data space. A case study illustrates that our model is well suited for a simultaneous assessment of transcript discovery and differential expression, while remaining competitive with methods that perform only one of these tasks

Stress and eating behavior : a daily diary study in youngsters

Background: Overweight and obesity are growing problems, with more attention recently, to the role of stress in the starting and maintaining process of these clinical problems. However, the mechanisms are not yet known and well-understood; and ecological momentary analyses like the daily variations between stress and eating are far less studied. Emotional eating is highly prevalent and is assumed to be an important mechanism, as a maladaptive emotion regulation (ER) strategy, in starting and maintaining the vicious cycle of (pediatric) obesity. Objectives: The present study aims to investigate in youngsters (10 - 17 years) the daily relationship between stress and the trajectories of self-reported eating behavior (desire to eat motives; hunger eating motives and snacking) throughout 1 week; as well as the moderating role of emotion regulation and emotional eating in an average weight population. Methods: Participants were 109 average weighted youngsters between the age of 10 and 17 years (M-age = 13.49; SD = 1.64). The youngsters filled in a trait-questionnaire on emotion regulation and emotional eating at home before starting the study, and answered an online diary after school time, during seven consecutive days. Desire to eat motives, hunger eating motives and snacking were assessed daily for seven consecutive days. Results: Using multilevel analyses results revealed that daily stress is significantly associated with trajectories of desire to eat motives and hunger eating motives. No evidence was found for the moderating role of maladaptive ER in these relationships; marginally significant evidence was found for the moderating role of emotional eating in the trajectories of desire to eat and snacking. Discussion: These results stress the importance of looking into the daily relationship between stress and eating behavior parameters, as both are related with change over and within days. More research is needed to draw firm conclusion on the moderating role of ER strategies and emotional eating

Eicosanoid Control Over Antigen Presenting Cells in Asthma

Asthma is a common lung disease affecting 300 million people worldwide. Allergic asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne allergens, that leads to eosinophilic inflammation, reversible bronchoconstriction, and mucus overproduction. Other forms of asthma are controlled by an eosinophil-rich innate ILC2 response driven by epithelial damage, whereas in some patients with more neutrophilia, the disease is driven by Th17 cells. Dendritic cells (DCs) and macrophages are crucial regulators of type 2 immunity in asthma. Numerous lipid mediators including the eicosanoids prostaglandins and leukotrienes influence key functions of these cells, leading to either pro- or anti-inflammatory effects on disease outcome. In this review, we will discuss how eicosanoids affect the functions of DCs and macrophages in the asthmatic lung and how this leads to aberrant T cell differentiation that causes disease

Melilite-bearing lavas in Mayotte (France): An insight into the mantle source below the Comores

International audienceOcean island basalts (OIB) from the Comores archipelago (Indian Ocean) display mineralogical and geochemical features different from the other Indian OIB. We present here new geochronological data (40Ar/39Ar), major and trace element compositions and isotopic (Sr, Nd, Pb) ratios of silica-undersaturated alkaline rocks from Mayotte, the oldest island of the Comores. Two trends are defined using major element composition: (1) a highly silica-undersaturated trend which includes basanites, (melilite-bearing) nephelinites, intermediate lavas and phonolites from the southern part of the island and (2) a moderately silica-undersaturated trend which is mainly represented by alkali basalts, basanites, intermediate lavas and phonolites from the northern part of the island. Both trends could be explained, to some extent, by variable degrees of partial melting. Normative larnite-bearing olivine melilitites and nephelinites exhibit, in addition to their high silica-undersaturation, elevated concentrations in CaO (>12wt.%) and P2O5 (up to 1.35wt.%). These exceptional rocks would result from low degree deep partial melting of a CO2-metasomatized source in the presence of carbonate (probably dolomite) and apatite. Igneous rocks from southern and northwestern shield volcanoes are characterized by a radiogenic Pb composition, revealing the existence of a HIMU (high μ=238U/204Pb) component in their source. Its influence decreases from the main building stage (>10.6-~3.0Ma) to the post-shield stage for the benefit of a depleted MORB-mantle (DMM) component, especially in the north central rocks. This feature would reflect increasing melting degrees of the depleted dominant source, bearing small-scale HIMU heterogeneities progressively consumed with time. The HIMU signature might have been introduced in the Comorian lithospheric mantle by thermal erosion or delamination of a continental lithosphere during the Gondwana break-up. The other islands of the Comores archipelago (Moheli, Anjouan and "La Grille" type lavas from Grande Comore) display also a DMM-HIMU mixing trend. Only a few lavas from Grande Comore ("Karthala" type) and one sample from Mayotte show the clear EM1 contribution (87Sr/86Sr>0.7035) of the Comorian plume

Emotion regulation training in the treatment of obesity in young adolescents : protocol for a randomized controlled trial

Background: The prevalence rates of childhood obesity are increasing. The current multidisciplinary treatments for (childhood) obesity are effective but only moderately and in the short term. A possible explanation for the onset and maintenance of childhood obesity is that it reflects a maladaptive mechanism for regulating high levels of stress and emotions. Therefore, the current RCT study aims to test the effectiveness of adding an emotion regulation training to care as usual (multidisciplinary obesity treatment) in young inpatients (10–14) involved in an obesity treatment program compared to care as usual alone. The research model for this RCT study states that when high levels of stress are regulated in a maladaptive way, this can contribute to the development of obesity. Methods: The current study will recruit 140 youngsters (10–14 years) who are involved in an inpatient multidisciplinary obesity treatment (MOT) program. After giving consent to participate in the study, youngsters will be randomly assigned, during consecutive waves, to one of two conditions: care as usual (receiving MOT) or intervention (receiving MOT in addition to emotion regulation training). The training itself consists of 12 weekly sessions, followed by a booster session after 3 and 5 months. The participants will be tested pretraining, posttraining, and at 6 months’ follow-up. We hypothesize that, compared to the control condition, youngsters in the intervention condition will (1) use more adaptive emotion regulation strategies and (2) report less emotional eating, both primary outcome measures. Moreover, on the level of secondary outcome measures, we hypothesize that youngsters in the intervention condition, compared with the control condition, will (3) report better sleep quality, (4) undergo improved weight loss and weight loss maintenance, and (5) experience better long-term (6-months) psychological well-being. Discussion: This study will add to both the scientific and clinical literature on the role of emotion regulation in the development and maintenance of different psychopathologies, as emotion regulation is a transdiagnostic factor. Trial registration: The RCT study protocol is registered at ISRCTN Registry, with study ID “ISRCTN 83822934.” Registered on 13 December 2017

The ORMDL3 asthma susceptibility gene regulates systemic ceramide levels without altering key asthma features in mice

Background: Genome-wide association studies in asthma have repeatedly identified single nucleotide polymorphisms in the ORM (yeast)-like protein isoform 3 (ORMDL3) gene across different populations. Although the ORM homologues in yeast are well-known inhibitors of sphingolipid synthesis, it is still unclear whether and how mammalian ORMDL3 regulates sphingolipid metabolism and whether altered sphingolipid synthesis would be causally related to asthma risk. Objective: We sought to examine the in vivo role of ORMDL3 in sphingolipid metabolism and allergic asthma. Methods: Ormdl3-LacZ reporter mice, gene-deficient Ormdl3(-/-) mice, and overexpressing Ormdl3(Tg/wt) mice were exposed to physiologically relevant aeroallergens, such as house dust mite (HDM) or Alternaria alternata, to induce experimental asthma. Mass spectrometry-based sphingolipidomics were performed, and airway eosinophilia, T(H)2 cytokine production, immunoglobulin synthesis, airway remodeling, and bronchial hyperreactivity were measured. Results: HDM challenge significantly increased levels of total sphingolipids in the lungs of HDM-sensitized mice compared with those in control mice. In Ormdl3(Tg/wt) mice the allergen-induced increase in lung ceramide levels was significantly reduced, whereas total sphingolipid levels were not affected. Conversely, in liver and serum, levels of total sphingolipids, including ceramides, were increased in Ormdl3(-/-) mice, whereas they were decreased in Ormdl3(Tg/wt) mice. This difference was independent of allergen exposure. Despite these changes, all features of asthma were identical between wildtype, Ormdl3(Tg/wt), and Ormdl3(-/-) mice across several models of experimental asthma. Conclusion: ORMDL3 regulates systemic ceramide levels, but genetically interfering with Ormdl3 expression does not result in altered experimental asthma

Étude de l'évolution volcano-structurale et magmatique de Mayotte, Archipel des Comores, océan Indien : approches structurale, pétrographique, géochimique et géochronologique

Multi-disciplinary approach in Mayotte island allow to identify two volcanic systems : the South volcano is composed of strong undersaturated lavas forming a continuous series of the post-erosional phase. The "Septentrional" volcano is made up of less undersaturated lavas - which can be induced by a stronger melting degree - which form the shield building phase and post-erosional phase. Strontium and Neodymium isotopic ratios and traces elements studies revel incoherence in the evolution of the volcano in the classic hot-spot model hypothesis (Hawaii). The multikilometer scale extension identified in the North of the island could induce melting by decompression during the lithosphere thinning and explain the strong melting degree of the recent lavas of the North-East. The last ones are characterised by isotopic signature of oceanic lithosphere.L'étude multidisciplinaire de Mayotte permet d'identifier deux systèmes volcaniques : le système volcanique du Sud constitué de laves définissant une série continue fortement sous-saturée représentant la phase post-érosionelle du volcan ; le système volcanique Septentrional constitué de laves définissant une lignée évolutive moyennement sous-saturée s'expliquant par un plus fort degré de fusion que la précédente et réprésentant une phase de construction du bouclier et une phase post-érosionelle. L'étude des rapports isotopiques du Strontium et du Néodyme et des éléments traces révèle des contradictions dans le modèle d'évolution d'un volcan de point chaud classique (ex : Hawaï). L'extension d'ampleur pluri-kilométrique relevée au Nord de l'île pourrait engendrer une fusion par décompression lors de l'amincissement litosphérique et ainsi expliquer le fort taux de fusion des laves récentes du Nord-Est de signature isotopique caractéristique de lithosphère océanique