The Anthropology of Plague: Insights from Bioarcheological Analyses of Epidemic Cemeteries

Most research on historic plague has relied on documentary evidence, but recently researchers have examined the remains of plague victims to produce a deeper understanding of the disease. Bioarcheological analysis allows the skeletal remains of epidemic victims to bear witness to the contexts of their deaths. This is important for our understanding of the experiences of the vast majority of people who lived in the past, who are not typically included in the historical record. This paper summarizes bioarcheological research on plague, primarily investigations of the Black Death in London (1349–50), emphasizing what anthropology uniquely contributes to plague studies

Black Death Bodies

The fourteenth-century Black Death was one of the most important and devastating epidemics in human history. It caused or accelerated important demographic, economic, political, and social changes throughout the Old World and has therefore been the subject of scholarly research in a variety of fields, including history, anthropology, demography, and molecular biology. In this paper, we examine the Black Death (specifically, the first and second outbreaks of fourteenth-century plague, c. 1347–1351 and 1361–1362) from bioarchaeological and historical perspectives, focusing on attempts to reconstruct mortality patterns and addressing the questions: Who died in England during the Black Death? How did they die, where and when? We evaluate how historical and bioarchaeological sources are uniquely informative about these questions and highlight the limitations that are associated with each type of data. The combination of the two bodies of evidence, when possible, can provide insights that are not possible when each is analyzed in isolation

Sexual Stature Difference Fluctuations in Pre- And Post-black Death London as an Indicator of Living Standards

Objectives: The degree of sexual stature difference (SSD), the ratio of male to female height, is argued to be an indicator of living standards based on evidence that physical growth for males is more sensitive to environmental fluctuations. In a resource-poor environment, the degree of SSD is expected to be relatively low. The aim of this study is to comparatively assess SSD in medieval London in the context of repeated famine events and other environmental stressors before the Black Death (BD) and the improved living conditions that characterized the post-Black Death period. Methods: To test the hypothesis that a poor nutritional environment resulted in decreased SSD in medieval London, this study compares adult individuals from early pre-Black Death (c. 1000–1200), late pre-Black Death (c. 1200–1250) and post-Black Death (c. 1350–1540) cemetery contexts from London. Maximum tibial,femoral, and lower limb lengths were used as a proxy for stature, and SSD was calculated using the Chakraborty and Majumber index. Results: Compared to the late pre-BD period, we find a slighter higher degree of SSD in the post-BD period for all three stature proxies used. This increase is attributed to more exaggerated increases in stature for estimated males post-BD. Conclusions: This study demonstrates the importance of examining variables that are considered indicators of living standards in light of factors like selective mortality, catch-up growth, and urban migration patterns. Future research needs to further investigate how cultural and biological processes influence the mechanisms that produce adult stature

Household ecology and out-migration among ethnic Karen along the Thai-Myanmar border

Local migration in developing-world settings, particularly among rural populations, is an important yet understudied demographic process. Research on migration in such populations can help us test and inform anthropological and demographic theory. Furthermore, it can lead to a better understanding of modern population distributions and epidemiologic landscapes

mRNA encoding a bispecific single domain antibody construct protects against influenza A virus infection in mice

To date, mRNA-based biologics have mainly been developed for prophylactic and therapeutic vaccination to combat infectious diseases or cancer. In the past years, optimization of the characteristics of in vitro transcribed mRNA has led to significant reduction of the inflammatory responses. Thanks to this, mRNA therapeutics have entered the field of passive immunization. Here, we established an mRNA treatment that is based on mRNA that codes for a bispecific single-domain antibody construct that can selectively recruit innate immune cells to cells infected with influenza A virus. The constructs consist of a single-domain antibody that binds to the ectodomain of the conserved influenza A matrix protein 2, while the other single-domain antibody binds to the activating mouse Fc gamma receptor IV. Formulating the mRNA into DOTAP (1,2-dioleoyl-3trimethylammonium-propane)/cholesterol nanoparticles and delivering these intratracheally to mice allowed the production of the bispecific single-domain antibody in the lungs, and administration of these mRNA-particles prior to influenza A virus infection was associated with a significant reduction in viral titers and a reduced morbidity in mice. Overall, our data provide evidence that the local delivery of mRNA encoding a bispecific single-domain antibody format in the lungs could be a promising pulmonary antiviral prophylactic treatment

TMG 1 (2014): Pandemic Disease in the Medieval World: Rethinking the Black Death, ed. Monica Green

The plague organism (Yersinia pestis) killed an estimated 40% to 60% of all people when it spread rapidly through the Middle East, North Africa, and Europe in the fourteenth century: an event known as the Black Death. Previous research has shown, especially for Western Europe, how population losses then led to structural economic, political, and social changes. But why and how did the pandemic happen in the first place? When and where did it begin? How was it sustained? What was its full geographic extent? And when did it really end? Pandemic Disease in the Medieval World is the first book to synthesize the new evidence and research methods that are providing fresh answers to these crucial questions. It was only in 2011, thanks to ancient DNA recovered from remains unearthed in London’s East Smithfield cemetery, that the full genome of the plague pathogen was identified. This single-celled organism probably originated 3000-4000 years ago and has caused three pandemics in recorded history: the Justinianic (or First) Plague Pandemic, around 541-750; the Black Death (Second Plague Pandemic), conventionally dated to the 1340s; and the Third Plague Pandemic, usually dated from around 1894 to the 1930s. This ground-breaking book brings together scholars from the humanities and social and physical sci­ences to address the question of how recent work in genetics, zoology, and epi­de­miology can enable a rethinking of the Black Death\u27s global reach and its larger historical significance. It forms the inaugural double issue of The Medieval Globe, a new journal sponsored by the Program in Medieval Studies at the University of Illinois at Urbana-Champaign. This issue of The Medieval Globe is published with the support of the World History Center at the University of Pittsburgh.https://scholarworks.wmich.edu/medieval_globe/1000/thumbnail.jp

Ancient Pathogen Dna in Archaeological Samples Detected With a Microbial Detection Array

Ancient human remains of paleopathological interest typically contain highly degraded DNA in which pathogenic taxa are often minority components, making sequence-based metagenomic characterization costly. Microarrays may hold a potential solution to these challenges, offering a rapid, affordable and highly informative snapshot of microbial diversity in complex samples without the lengthy analysis and/or high cost associated with high-throughput sequencing. Their versatility is well established for modern clinical specimens, but they have yet to be applied to ancient remains. Here we report bacterial profiles of archaeological and historical human remains using the Lawrence Livermore Microbial Detection Array (LLMDA). The array successfully identified previously-verified bacterial human pathogens, including Vibrio cholerae (cholera) in a 19th century intestinal specimen and Yersinia pestis (“Black Death” plague) in a medieval tooth, which represented only minute fractions (0.03% and 0.08% alignable high-throughput shotgun sequencing reads) of their respective DNA content. This demonstrates that the LLMDA can identify primary and/or co-infecting bacterial pathogens in ancient samples, thereby serving as a rapid and inexpensive paleopathological screening tool to study health across both space and time

The First New Zealanders? An Alternative Interpretation of Stable Isotope Data from Wairau Bar, New Zealand.

PLOS ONE Volume 8 includes an article “The First New Zealanders: Patterns of Diet and Mobility Revealed through Isotope Analysis”. The paper proposes that burial groups within the settlement phase site of Wairau Bar differ in terms of dietary stable isotopes and 87Sr/86Sr. The authors argue this difference is probably due to one group being a founding population while the other burials are later. Here we review the work of Kinaston et al. and present an alternative analysis and interpretation of the isotopic data. Treating the isotope data independently from cultural and biological factors we find that sex best explains dietary variation. Our reassessment of 87Sr/86Sr confirms the authors original finding of high mobility of early New Zealanders but suggests a larger range of individuals should be considered ‘non-local’ on current evidence

Climate Change, Human Health, and Resilience in the Holocene

Climate change is an indisputable threat to human health, especially for societies already confronted with rising social inequality, political and economic uncertainty, and a cascade of concurrent environmental challenges. Archaeological data about past climate and environment provide an important source of evidence about the potential challenges humans face and the long-term outcomes of alternative short-term adaptive strategies. Evidence from well-dated archaeological human skeletons and mummified remains speaks directly to patterns of human health over time through changing circumstances. Here, we describe variation in human epidemiological patterns in the context of past rapid climate change (RCC) events and other periods of past environmental change. Case studies confirm that human communities responded to environmental changes in diverse ways depending on historical, sociocultural, and biological contingencies. Certain factors, such as social inequality and disproportionate access to resources in large, complex societies may influence the probability of major sociopolitical disruptions and reorganizations—commonly known as “collapse.” This survey of Holocene human–environmental relations demonstrates how flexibility, variation, and maintenance of Indigenous knowledge can be mitigating factors in the face of environmental challenges. Although contemporary climate change is more rapid and of greater magnitude than the RCC events and other environmental changes we discuss here, these lessons from the past provide clarity about potential priorities for equitable, sustainable development and the constraints of modernity we must address