Attitudes Toward Couple Therapy in Helping Profession Graduate Students

A core issue of couple therapy is the evident delay in help-seeking behaviours among distressed couples. This study had two main objectives. The first objective was to examine if there is a negative stigmatization associated with attendance at couple therapy and whether this is related to a person\u27s willingness to attend. The second objective was to examine whether couple therapy is perceived as a resource to be used once distress levels are severe and other options have been exhausted. This study used a survey methodology with qualitative components and participants consisted mainly of graduate students enrolled in helping profession programs. Overall attitudes toward seeking marital therapy were found to be significantly related to willingness to seek help. Those who were less willing to seek help for a relationship issue had less positive attitudes toward help seeking. This finding was consistent across the 4 subscales of the attitudes toward help seeking scale (ASPPH-MT), including stigma tolerance (r = .38, p \u3c .00). The qualitative components of this study illustrated elements of stigma of couple therapy attendance, which addressed the first objective of this study, as well as a stigma of having relationship difficulties and needing external help to resolve these conflicts. It was found that significantly more people indicated that above moderate to severe distress is necessary prior to seeking couple therapy than people who indicated that mild to moderate distress is necessary (x2(1, N = 106) = 77.396, p \u3c.001) which addressed the second objective of this study. Overall, in this sample, the findings provided important clarification for two factors: (i) that there is a perception that couple therapy attendance is stigmatized and one\u27s sensitivity to that stigma is related to willingness to seek help and (ii) that couple therapy and attendance is a resource for those who are significantly distressed

A High Throughput, Whole Cell Screen for Small Molecule Inhibitors of the Mitotic Spindle Checkpoint Identifies OM137, a Novel Aurora Kinase Inhibitor

In mitosis, the kinetochores of chromosomes that lack full microtubule attachments and/or mechanical tension activate a signaling pathway called the mitotic spindle checkpoint that blocks progression into anaphase and prevents premature segregation of the chromatids until chromosomes become aligned at the metaphase plate. The spindle checkpoint is responsible for arresting cells in mitosis in response to chemotherapeutic spindle poisons such as paclitaxel or vinblastine. Some cancer cells show a weakened checkpoint signaling system that may contribute to chromosome instability in tumors. Because complete absence of the spindle checkpoint leads to catastrophic cell division, we reasoned that drugs targeting the checkpoint might provide at therapeutic window in which the checkpoint would be eliminated in cancer cells but sufficiently preserved in normal cells. We developed an assay to identify lead compounds that inhibit the spindle checkpoint. Most cells respond to microtubule drugs by activating the spindle checkpoint and arresting in mitosis with a rounded morphology. Our assay depended on the ability of checkpoint inhibitor compounds to drive mitotic exit and cause cells to flatten onto the substrate in the continuous presence of microtubule drugs. In this study, we characterize one of the compounds, OM137, as an inhibitor of Aurora kinases. We find that this compound is growth inhibitory to cultured cells when applied at high concentration and potentiates the growth inhibitory effects of subnanomolar concentrations of paclitaxel

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

Addition of reversine to dividing cells ejects Mad1 and the RZZ complex from unattached kinetochores and prevents resolution of incorrect chromosome–microtubule attachments (see also related papers by Hewitt et al. and Maciejowski et al. in this issue)

Caenorhabditis elegans Cyclin B3 Is Required for Multiple Mitotic Processes Including Alleviation of a Spindle Checkpoint–Dependent Block in Anaphase Chromosome Segregation

The master regulators of the cell cycle are cyclin-dependent kinases (Cdks), which influence the function of a myriad of proteins via phosphorylation. Mitotic Cdk1 is activated by A-type, as well as B1- and B2-type, cyclins. However, the role of a third, conserved cyclin B family member, cyclin B3, is less well defined. Here, we show that Caenorhabditis elegans CYB-3 has essential and distinct functions from cyclin B1 and B2 in the early embryo. CYB-3 is required for the timely execution of a number of cell cycle events including completion of the MII meiotic division of the oocyte nucleus, pronuclear migration, centrosome maturation, mitotic chromosome condensation and congression, and, most strikingly, progression through the metaphase-to-anaphase transition. Our experiments reveal that the extended metaphase delay in CYB-3–depleted embryos is dependent on an intact spindle assembly checkpoint (SAC) and results in salient defects in the architecture of holocentric metaphase chromosomes. Furthermore, genetically increasing or decreasing dynein activity results in the respective suppression or enhancement of CYB-3–dependent defects in cell cycle progression. Altogether, these data reveal that CYB-3 plays a unique, essential role in the cell cycle including promoting mitotic dynein functionality and alleviation of a SAC–dependent block in anaphase chromosome segregation

Depression and anxiety in critical transitional periods in an adolescent's life

Depression and anxiety during critical moments in an adolescent’s life, such as entering and graduating high school, may be more prevalent than many individuals think. I examined adolescents and rated the amount of depression and anxiety they were experiencing, as well as what coping mechanisms were common among these adolescents and whether they were healthy or unhealthy. The research involved going to local school districts around the Menomonie, Wisconsin area and evaluating previous surveys that the school districts have already administered. The surveys gathered by the school districts analyzed depression and anxiety in the students, and what coping mechanisms the students were using with a heavy concentration on substance abuse knowledge and use. The purpose of this study is to find out how much depression and anxiety is affecting these students as well as what coping mechanisms they are using. We also investigated healthy resources students are using in their school district as well as in their own community. Furthermore, the purpose is to raise awareness to the school systems about how students are dealing with depression and anxiety and to help students identify the resources that are available to them.University of Wisconsin--Stout. Research Service

Playing surfaces and knee injuries in UWRF athletes

11 p. Includes bibliographical references.The purpose of this research was to explore the effect of playing surfaces on the amount of severe knee injuries in UWRF athletes

Playing surfaces and knee injuries

Color poster with text detailing research conducted by Connor Graves, Matt DeMoe, Katie Slowiak and Brittany Erickson, which investigated the effect of playing surfaces on the amount of severe knee injuries to athletes at the University of Wisconsin-River Falls.The purpose of this study was to explore the effect of playing surfaces on the amount of severe knee injuries in UWRF athletes

sj-pdf-1-imr-10.1177_03000605231213231 - Supplemental material for Incidence and risk factors of post-stroke seizures and epilepsy: systematic review and meta-analysis

Supplemental material, sj-pdf-1-imr-10.1177_03000605231213231 for Incidence and risk factors of post-stroke seizures and epilepsy: systematic review and meta-analysis by Aathmika Nandan, Yi Mei Zhou, Lindsay Demoe, Adnan Waheed, Puneet Jain and Elysa Widjaja in Journal of International Medical Research</p