Differential Effects of Neonatal Testosterone Treatment on Aggression in Two Selection Lines of Mice

Selection lines of mice, artificially selected for aggression based upon the attack latency score (ALS), were used. In order to determine the relative contribution of neonatal testosterone (T) in the development of aggression, we vary the plasma-T level in males of both selection lines on the day of birth. At 14 weeks the ALS was measured. Neonatal T treatment results in a reduction of aggression in the long attack latency (LAL) line, whereas aggressive behaviour of the short attack latency (SAL) line is not affected. Both selection lines show reduction in testicular weight, although the total amount of T-producing Leydig cells was not affected. Neonatal T may cause a permanent reduction in aggressive behaviour in the LAL line only, probably due to differential appearance of critical periods. It is suggested that the difference in aggressive behaviour between SAL and LAL selection lines is due to a prenatally determined difference in neonatal T sensitivity of the brain.

The nature of close companions of the BL Lac Objects 1ES 0502+675 and 1ES 1440+122

We report on deep radio images and optical spectroscopy of two BL Lac objects that have very close compact companions. The two targets, 1ES 0502+675 and 1ES 1440+122, were selected from the HST imaging survey of 110 BL Lacs as candidates for possible gravitational lensing. The new observations clearly demonstrate that the companion objects are not secondary images of the active nuclei but, in spite of the relatively low chance projection probability, foreground Galactic stars. Gravitational lensing appears to be unimportant to the BL Lac phenomenon. We discuss the radio properties of the BL Lac objects in the context of standard beaming models, and show they are as expected for beamed FRI radio galaxies.Comment: 13 pages, 5 figures, ApJ in pres

Why We Can No Longer Ignore Consecutive Disasters

In recent decades, a striking number of countries have suffered from consecutive disasters: events whose impacts overlap both spatially and temporally, while recovery is still under way. The risk of consecutive disasters will increase due to growing exposure, the interconnectedness of human society, and the increased frequency and intensity of nontectonic hazard. This paper provides an overview of the different types of consecutive disasters, their causes, and impacts. The impacts can be distinctly different from disasters occurring in isolation (both spatially and temporally) from other disasters, noting that full isolation never occurs. We use existing empirical disaster databases to show the global probabilistic occurrence for selected hazard types. Current state‐of‐the art risk assessment models and their outputs do not allow for a thorough representation and analysis of consecutive disasters. This is mainly due to the many challenges that are introduced by addressing and combining hazards of different nature, and accounting for their interactions and dynamics. Disaster risk management needs to be more holistic and codesigned between researchers, policy makers, first responders, and companies

The obesity paradox in lung cancer : associations with body size versus body shape

Background: The association between obesity and lung cancer (LC) remains poorly understood. However, other indices of obesity on the basis of body shape instead of body size have not been examined yet. The aim of this study was to evaluate the association between different indices of body size and body shape and the risk of LC. In particular, this study examined the association between A Body Shape Index, a more precise indicator of abdominal fat than traditional anthropometric measures, and the risk of LC. Methods: In the prospective cohort the Rotterdam Study, we analysed data of 9,689 participants. LC diagnoses were based on medical records and anthropometric measurements were assessed at baseline. Cox-regression analyses with corresponding Hazard Ratios were used to examine the association between the anthropometric measurements and the risk of LC with adjustment for potential confounders. Potential non-linear associations were explored with cubic splines using the Likelihood ratio (LR) test. Results: During follow-up, 319 participants developed LC. Body mass Index (BMI) was inversely associated with the risk of lung cancer (HR 0.94, 95% CI: 0.91-0.97) and persisted after excluding lung cancer cases during the first 10 years of follow-up. There was evidence for a non-linear association between BMI and the risk of lung cancer (0,04, df = 1), which indicated that the inverse association between BMI and lung cancer was mainly present in non-obese participants. Waist circumference (WC) (HR 1.03 95% CI: 1.01-1.05), Waist-to-Hip Ratio (WHR) (HR 1.23 95% CI: 1.09-1.38) and ABSI (A Body Shape Index) (HR 1.17 95% CI: 1.05-1.30) were positively and linearly associated with the risk of lung cancer. Conclusions: Body shape rather than body size may be an important risk indicator of LC. Future research should focus on the role of visceral fat and the risk of LC as well as the underlying mechanisms

Obscuration and Origin of Nuclear X-ray emission in FR I Radio Galaxies

We present X-ray observations of the nuclear region of 25 Fanaroff-Riley I radio galaxies from the 3CRR and B2 catalogs, using data from the Chandra and XMM archives. We find the presence of a X-ray Central Compact Core (CCCX) in 13/25 sources, in 3/25 sources the detection of a CCCX is uncertain, while in the remaining 9/25 sources no CCCX is found. All the sources are embedded in a diffuse soft X-ray component, generally on kpc-scales, which is in agreement with the halo of the host galaxy and/or with the intracluster medium. The X-ray spectra of the cores are described by a power law with photon indices Gamma=1.1 - 2.6. In 8 sources excess absorption over the Galactic value is detected, with rest-frame column densities N_H^z ~ 10^20 - 10^21 cm^-2; thus, we confirm the previous claim based on optical data that most FRI radio galaxies lack a standard optically-thick torus. We find significant correlations between the X-ray core luminosity and the radio and optical luminosities, suggesting that at least a fraction of the X-ray emission originates in a jet; however, the origin of the X-rays remains ambiguous. If the X-ray emission is entirely attributed to an isotropic, accretion-related component, we find very small Eddington ratios, L_bol/L_Edd ~ 10^-3 - 10^-8, and we calculate the radiative efficiency to be eta ~ 10^-2 - 10^-6, based on the Bondi accretion rates from the spatial analysis. This suggests that radiatively inefficient accretion flows are present in the cores of low-power radio galaxies.Comment: 20 pages, 7 figures, accepted for publication in The Astrophysical Journa

Sex-specific Mendelian randomisation to assess the causality of sex differences in the effects of risk factors and treatment: spotlight on hypertension

Hypertension is a key modifiable risk factor for cardiovascular disease. Several observational studies have found a stronger association of blood pressure and cardiovascular disease risk in women compared to men. Since observational studies can be affected by sex-specific residual confounding and reverse causation, it remains unclear whether these differences reflect actual differential effects. Other study designs are needed to uncover the causality of sex differences in the strength of risk factor and treatment effects. Mendelian randomisation (MR) uses genetic variants as instrumental variables to provide evidence about putative causal relations between risk factors and outcomes. By exploiting the random allocation of genes at gamete forming, MR is unaffected by confounding and results in more reliable causal effect estimates. In this review, we discuss why and how sex-specific MR and cis-MR could be used to study sex differences in risk factor and drug target effects. Sex-specific MR can be helpful to strengthen causal inferences in the field of sex differences, where it is often challenging to distinguish nature from nurture. The challenge of sex-specific (drug target) MR lays in leveraging robust genetic instruments from sex-specific GWAS studies which are not commonly available. Knowledge on sex-specific causal effects of hypertension, or other risk factors, could improve clinical practice and health policies by tailoring interventions based on personalised risk. Drug target MR can help to determine the anticipated on-target effects of a drug compound and to identify targets to pursue in drug developmen

An adaptive, real-time cadence algorithm for unconstrained sensor placement

This paper evaluates a new and adaptive real-time cadence detection algorithm (CDA) for unconstrained sensor placement during walking and running. Conventional correlation procedures, dependent on sensor position and orientation, may alternately detect either steps or strides and consequently suffer from false negatives or positives. To overcome this limitation, the CDA validates correlation peaks as strides using the Sylvester's criterion (SC). This paper compares the CDA with conventional correlation methods.22 volunteers completed 7 different circuits (approx. 140 m) at three gaits-speeds: walking (1.5 m s- 1), running (3.4 m s- 1), and sprinting (5.2 and 5.7 m s- 1), disturbed by various gait-related activities. The algorithm was simultaneously evaluated for 10 different sensor positions. Reference strides were obtained from a foot sensor using a dedicated offline algorithm.The described algorithm resulted in consistent numbers of true positives (85.6-100.0%) and false positives (0.0-2.9%) and showed to be consistently accurate for cadence feedback across all circuits, subjects and sensors (mean ± SD: 98.9 ± 0.2%), compared to conventional cross-correlation (87.3 ± 13.5%), biased (73.0 ± 16.2) and unbiased (82.2 ± 20.6) autocorrelation procedures.This study shows that the SC significantly improves cadence detection, resulting in robust results for various gaits, subjects and sensor positions

X-ray-emitting Atmospheres of B2 Radio Galaxies

We report ROSAT PSPC spatial and spectral analysis of the eight B2 radio galaxies NGC 315, NGC 326, 4C 35.03, B2 0326+39, NGC 2484, B2 1040+31, B2 1855+37, and 3C 449, expected to be representative of the class of low-power radio galaxies. Multiple X-ray components are present in each, and the gas components have a wide range of linear sizes and follow an extrapolation of the cluster X-ray luminosity/temperature correlation, implying that there is no relationship between the presence of a radio galaxy and the gas fraction of the environment. No large-scale cooling flows are found. There is no correlation of radio-galaxy size with the scale or density of the X-ray atmosphere. This suggests that it is processes on scales less than those of the overall gaseous environments which are the major influence on radio-source dynamics. The intergalactic medium is usually sufficient to confine the outer parts of the radio structures, in some cases even to within 5 kpc of the core. In the case of NGC 315, an extrapolation suggests that the pressure of the atmosphere may match the minimum pressure in the radio source over a factor of about 40 in linear size (a factor of about 1600 in pressure).Comment: 34 pages, including 10 figures, using aasms4.sty To appear in the Ap

The relationship between parenting, family interaction and childhood dental caries: A case-control study

a b s t r a c t The aim of this case-control study was to explore the relationship between parenting practices, parent echild interaction and childhood dental caries, using a sample of 5e8-year old children from the Netherlands. Cases were defined as children with four or more decayed, missing or filled teeth and controls were caries free. Cases (n ¼ 28) and controls (n ¼ 26) were recruited from a referral centre for paediatric dental care and a general dental practice, respectively. Parenting practices and parentechild interactions of the child's primary caregiver were observed using Structured Interaction Tasks and subsequently rated on seven dimensions: positive involvement, encouragement, problem-solving, discipline, monitoring, coercion and interpersonal atmosphere. All Structured Interaction Tasks were videotaped, and coded by trained and calibrated observers blind to the dental condition. Differences in parenting dimensions between cases and controls were analysed using multivariate analysis of variance, independent samples T-tests, c 2 -tests and multiple logistic regression analyses. Controls had significantly higher scores on the dimensions positive involvement, encouragement, problem-solving and interpersonal atmosphere, compared to cases. Parents of controls were also less likely to show coercive behaviours. These associations remained statistically significant after adjustment for the mother's education level, tooth brushing frequency and the frequency of consuming sugary foods and drinks, except for coercion. There was no significant difference in discipline between cases and controls. In conclusion, this case-control study found a significant relationship between parenting practices, parent echild interaction quality and childhood dental caries. Our findings suggest that parenting practices may be an important factor to consider in caries preventive programs