Wear of human teeth: a tribological perspective

The four main types of wear in teeth are attrition (enamel-on-enamel contact), abrasion (wear due to abrasive particles in food or toothpaste), abfraction (cracking in enamel and subsequent material loss), and erosion (chemical decomposition of the tooth). They occur as a result of a number of mechanisms including thegosis (sliding of teeth into their lateral position), bruxism (tooth grinding), mastication (chewing), toothbrushing, tooth flexure, and chemical effects. In this paper the current understanding of wear of enamel and dentine in teeth is reviewed in terms of these mechanisms and the major influencing factors are examined. In vitro tooth wear simulation and in vivo wear measurement and ranking are also discussed

A doubly covariant formula of deficit angle and its application to six-dimensional braneworld

We reformulate boundary conditions for axisymmetric codimension-2 braneworlds in a way which is applicable to linear perturbation with various gauge conditions. Our interest is in the thin brane limit and thus this scheme assumes that the perturbations are also axisymmetric and that the surface energy-momentum tensor of the brane is proportional to its induced metric. An advantage of our scheme is that it allows much more freedom for convenient coordinate choices than the other methods. This is because in our scheme, the coordinate system in the bulk and that on the brane are completely disentangled. Therefore, the latter does not need to be a subset of the former and the brane does not need to stay at a fixed bulk coordinate position. The boundary condition is manifestly doubly covariant: it is invariant under gauge transformations in the bulk and at the same time covariant under those on the brane. We take advantage of the double covariance when we analyze the linear perturbation of a particular model of six-dimensional braneworld with warped flux compactification.Comment: 25 pages, REVTeX4; published in CQ

The Landau Pole and Z′Z^{\prime} decays in the 331 bilepton model

We calculate the decay widths and branching ratios of the extra neutral boson $Z^{\prime}$ predicted by the 331 bilepton model in the framework of two different particle contents. These calculations are performed taken into account oblique radiative corrections, and Flavor Changing Neutral Currents (FCNC) under the ansatz of Matsuda as a texture for the quark mass matrices. Contributions of the order of $10^{-1}-10^{-2}$ are obtained in the branching ratios, and partial widths about one order of magnitude bigger in relation with other non- and bilepton models are also obtained. A Landau-like pole arise at 3.5 TeV considering the full particle content of the minimal model (MM), where the exotic sector is considered as a degenerated spectrum at 3 TeV scale. The Landau pole problem can be avoid at the TeV scales if a new leptonic content running below the threshold at $$ TeV is implemented as suggested by other authors.Comment: 20 pages, 5 figures, LaTeX2

Rapid short-pulses of focused ultrasound and microbubbles deliver a range of agent sizes to the brain

Focused ultrasound and microbubbles can non-invasively and locally deliver therapeutics and imaging agents across the blood–brain barrier. Uniform treatment and minimal adverse bioeffects are critical to achieve reliable doses and enable safe routine use of this technique. Towards these aims, we have previously designed a rapid short-pulse ultrasound sequence and used it to deliver a 3 kDa model agent to mouse brains. We observed a homogeneous distribution in delivery and blood–brain barrier closing within 10 min. However, many therapeutics and imaging agents are larger than 3 kDa, such as antibody fragments and antisense oligonucleotides. Here, we evaluate the feasibility of using rapid short-pulses to deliver higher-molecular-weight model agents. 3, 10 and 70 kDa dextrans were successfully delivered to mouse brains, with decreasing doses and more heterogeneous distributions with increasing agent size. Minimal extravasation of endogenous albumin (66.5 kDa) was observed, while immunoglobulin (~ 150 kDa) and PEGylated liposomes (97.9 nm) were not detected. This study indicates that rapid short-pulses are versatile and, at an acoustic pressure of 0.35 MPa, can deliver therapeutics and imaging agents of sizes up to a hydrodynamic diameter between 8 nm (70 kDa dextran) and 11 nm (immunoglobulin). Increasing the acoustic pressure can extend the use of rapid short-pulses to deliver agents beyond this threshold, with little compromise on safety. This study demonstrates the potential for deliveries of higher-molecular-weight therapeutics and imaging agents using rapid short-pulses

Discovery of an Unusual Dwarf Galaxy in the Outskirts of the Milky Way

In this Letter, we announce the discovery of a new dwarf galaxy, Leo T, in the Local Group. It was found as a stellar overdensity in the Sloan Digital Sky Survey Data Release 5 (SDSS DR5). The color-magnitude diagram of Leo T shows two well-defined features, which we interpret as a red giant branch and a sequence of young, massive stars. As judged from fits to the color-magnitude diagram, it lies at a distance of about 420 kpc and has an intermediate-age stellar population with a metallicity of [Fe/H]= -1.6, together with a young population of blue stars of age of 200 Myr. There is a compact cloud of neutral hydrogen with mass roughly 10^5 solar masses and radial velocity 35 km/s coincident with the object visible in the HIPASS channel maps. Leo T is the smallest, lowest luminosity galaxy found to date with recent star-formation. It appears to be a transition object similar to, but much lower luminosity than, the Phoenix dwarf.Comment: Ap J (Letters) in press, the subject of an SDSS press release toda

XMM-Newton survey of the Local Group galaxy M 33

In an XMM-Newton raster observation of the bright Local Group spiral galaxy M 33 we study the population of X-ray sources (X-ray binaries, supernova remnants) down to a 0.2--4.5 keV luminosity of 10^35 erg/s -- more than a factor of 10 deeper than earlier ROSAT observations. EPIC hardness ratios and optical and radio information are used to distinguish between different source classes. The survey detects 408 sources in an area of 0.80 square degree. We correlate these newly detected sources with earlier M 33 X-ray catalogues and information from optical, infra-red and radio wavelengths. As M 33 sources we detect 21 supernova remnants (SNR) and 23 SNR candidates, 5 super-soft sources, and 2 X-ray binaries (XRBs). There are 267 sources classified as hard, which may either be XRBs or Crab-like SNRs in M 33 or background AGN. The 44 confirmed and candidate SNRs more than double the number of X-ray detected SNRs in M 33. 16 of these are proposed as SNR candidates from the X-ray data for the first time. On the other hand, there are several sources not connected to M 33: five foreground stars, 30 foreground star candidates, 12 active galactic nucleus candidates, one background galaxy and one background galaxy candidate. Extrapolating from deep field observations we would expect 175 to 210 background sources in this field. This indicates that about half of the sources detected are sources within M 33.Comment: 14 pages, 6 figures, accepted for publication in A&A, the images of Figs. 1,2,3,4,6 are available in jpg format, a full version of the paper is available at ftp://ftp.xray.mpe.mpg.de/people/fwh/docs/M33_AA0068.p

Scalar Bilepton Dark Matter

In this work we show that 3-3-1 model with right-handed neutrinos has a natural weakly interacting massive particle (WIMP) dark mater candidate. It is a complex scalar with mass of order of some hundreds of GeV which carries two units of lepton number, a scalar bilepton. This makes it a very peculiar WIMP, very distinct from Supersymmetric or Extra-dimension candidates. Besides, although we have to make some reasonable assumptions concerning the several parameters in the model, no fine tunning is required in order to get the correct dark matter abundance. We also analyze the prospects for WIMP direct detection by considering recent and projected sensitivities for WIMP-nucleon elastic cross section from CDMS and XENON Collaborations.Comment: 21 pages, 8 figures, uses iopart.cls, same text as published version with a small different arrangement of figure