CRIANÇAS E ADOLESCENTES ÓRFÃOS: UM ESTUDO SOBRE A INFLUÊNCIA DA ORFANDADE NO PROCESSO DE FORMAÇÃO PSICOSSOCIAL E DESENVOLVIMENTO DA PERSONALIDADE

O presente estudo tem por objetivo investigar as influências conflituosas no desenvolvimento psicossocial de sujeitos órfãos de pai. Segundo diversos trabalhos que discutem a orfandade paterna, a ausência do genitor pode gerar situações aversivas de caráter psicossocial, de acordo com cada fase do desenvolvimento que o indivíduo se encontra. Participaram da pesquisa três adolescentes órfãos de pai, sendo que os mesmos foram entrevistados de forma individual com a finalidade de investigar por meio de pesquisa qualitativa descritiva, a orfandade e os fenômenos decorrentes da ausência da figura paterna em quatro diferentes temáticas: Aspectos do desenvolvimento infantil; Participação dos genitores no desenvolvimento; Relacionamento filho-pai; Avaliação do relacionamento com a família. Os conteúdos manifestos foram examinados pela técnica de análise de discurso. O estudo revelou que a ausência paterna afeta o desenvolvimento emocional de tal forma que os participantes da pesquisa expressam emoções regressivas na busca de reorganização psíquica, assim como pode vir acontecer durante a transição para fases posteriores ao longo da vida

Some arachnidan peptides with potential medical application

The search for new active drugs that can alleviate or cure different diseases is a constant challenge to researchers in the biological area and to the pharmaceutical industry. Historically, research has focused on the study of substances from plants. More recently, however, animal venoms have been attracting attention and studies have been successful in addressing treatment of accidents. Furthermore, venoms and their toxins have been considered good tools for prospecting for new active drugs or models for new therapeutic drugs. In this review, we discuss some possibilities of using different toxins, especially those from arachnid venoms, which have shown some potential application in diseases involving pain, hypertension, epilepsy and erectile dysfunction. A new generation of drugs is likely to emerge from peptides, including those found in animal venoms

Sarcopenia and risk of malnutrition as risk factors for complications from COVID-19

Objetivo: Este estudo teve como objetivo associar o risco nutricional e de sarcopenia com desfechos clínicos em pacientes idosos com COVID-19. Métodos: Trata-se de um estudo de coorte retrospectivo longitudinal. Idosos hospitalizados com diagnóstico de COVID-19 foram incluídos no estudo. O risco nutricional foi avaliado usando o Malnutrition Universal Screening Tool (MUST) e o risco de sarcopenia foi avaliado usando o SARC-F. As associações foram avaliadas por modelos logísticos multivariados. Resultados: No total, 127 pacientes (média de idade: 71,25 ±8,06 anos) foram acompanhados até o desfecho clínico. Risco de sarcopenia foi diagnosticado em 63,8% da amostra, enquanto risco nutricional foi observado em 72% deles. Além disso, 48,8% da amostra necessitoude internação em unidade de terapia intensiva (UTI), 38,6% necessitaram ventilação mecânica e 32,3% foram a óbito. Idosos com risco de sarcopenia tiveram maior chance de internação em UTI (OR: 5,62; IC 95%: 2,2-14,3), necessidade de ventilação mecânica (OR: 4,0; IC 95%: 1,5-10,2) e óbito (OR: 5,06; IC 95%: 1,7-14,2). O risco de desnutrição avaliado pelo MUST foi um importante fator de risco para óbito (OR = 30,15; IC 95%: 3,6-245,8; p<0,01). Conclusão: O risco de sarcopenia foi fator de risco para óbito, internação em UTI e ventilação mecânica,enquanto o risco nutricional foi fator de risco para óbito.Purpose: This study aimed to associate nutritional and sarcopenia risk with clinical outcomes in elderly patients with COVID-19. Methods: This is a longitudinal retrospective cohort study. Hospitalized elderly individuals diagnosed with COVID-19 were included in the study. Nutritional risk was assessed using the Malnutrition Universal Screening Tool (MUST), and Sarcopenia risk was assessed using the SARC-F. Associations were assessed throughmultivariable logistic models. Results: In total, 127 patients (mean age: 71.25 ±8.06 years) were followed up until the clinical outcome. Sarcopenia risk was diagnosed in 63.8% of the sample, whereas nutritional risk was observed in 72%. Hospitalization in the intensive care unit (ICU) was required in 48.8% of the sample, 38.6% required mechanicalventilation, and 32.3% died. Elderly individuals with sarcopenia risk were more likely to be hospitalized inICUs (OR: 5.62; 95%CI: 2.2-14.3), require mechanical ventilation (OR: 4.0; 95% CI: 1.5-10.2), and die (OR: 5.06; 95% CI: 1.7-14.2). The risk of malnutrition assessed through MUST was an important risk factor for death (OR = 30.15; 95% CI: 3.6-245.8; p<0.01). Conclusion: Sarcopenia risk was a risk factor for death, hospitalization in ICU, and mechanical ventilation, while nutritional risk was a risk factor for death

The physics of spreading processes in multilayer networks

The study of networks plays a crucial role in investigating the structure, dynamics, and function of a wide variety of complex systems in myriad disciplines. Despite the success of traditional network analysis, standard networks provide a limited representation of complex systems, which often include different types of relationships (i.e., "multiplexity") among their constituent components and/or multiple interacting subsystems. Such structural complexity has a significant effect on both dynamics and function. Throwing away or aggregating available structural information can generate misleading results and be a major obstacle towards attempts to understand complex systems. The recent "multilayer" approach for modeling networked systems explicitly allows the incorporation of multiplexity and other features of realistic systems. On one hand, it allows one to couple different structural relationships by encoding them in a convenient mathematical object. On the other hand, it also allows one to couple different dynamical processes on top of such interconnected structures. The resulting framework plays a crucial role in helping achieve a thorough, accurate understanding of complex systems. The study of multilayer networks has also revealed new physical phenomena that remain hidden when using ordinary graphs, the traditional network representation. Here we survey progress towards attaining a deeper understanding of spreading processes on multilayer networks, and we highlight some of the physical phenomena related to spreading processes that emerge from multilayer structure.Comment: 25 pages, 4 figure

Perspectives on the Trypanosoma cruzi-host cell receptor interaction

Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets

THE EVOLUTION OF TECHNOLOGY IN EDUCATION

A tecnologia na educação tem estado fortemente presente nessas últimas décadas. E já tem sido incorporada ao discurso de profissionais da educação, podendo chegar a diversos lugares. Há uma evolução da tecnologia nas instituições educacionais. Para uma evolução educacional, é preciso investimento. Atualmente temos uma carência nos instrumentos de estudo, porém existe uma ideia para quebrar esses paradigmas, de ambos os lados, ainda existe uma falta de amadurecimento dessa ideia. São incluí­das aulas presenciais, a distância e livros-textos em formato PDF. Existem vários tipos de aprendizagem, e podem alcançar todos os ní­veis de graduações distintas. Baseamos nossa pesquisa em cinco artigos anteriores e desenvolvemos um artigo de revisão.The technology in the attention of a scenario was serious in the last decades. And it has already been, founded to the discourse of professionals of education, being able to arrive at many places. There is technology in educational institutions. For an educational recovery it takes investment. "There is a lack in the instruments of study, because there is an idea to break paradigms, on both sides, there is still a lack of maturation of this idea. Can be useful at all levels of distinct rankings based on our research on previous articles, and we have developed a review article