Chronotopic identities : on the spacetime organization of who we are

An introduction to the concept of chronotopic identity work, applied to classroom discourse and proposed as an instrument for increasing accuracy in ethnographic description

Migrant youth push back. Virtual friendships and everyday resistance in the digital sphere

Resistance has proven to be a hard concept to define. Debates about resistance in the sociological and sociolinguistic literature cover many aspects: from the degree to which resistance can be seen as related to established social groups (see Rampton 1996), to the level of agentivity and intention that is required for an action to be regarded as resistant, to the type of social behavior that qualifies. Thus, while some see resistance as based on actions, others see it as based on cultural appropriation (Hall and Jefferson 1976).  In their comprehensive review of literature on the topic, Hollander and Einwohner (2004) conclude that resistance can be seen as consisting of action and opposition. In this paper, I analyze resistance from the point of view of opposition to ideas, social situations, institutional actions and processes that result or may result in discrimination or stereotyping of specific social groups, as negotiated in the digital sphere by migrant and non-migrant youth belonging to a school-based community. Indeed, it has been argued (Chiluwa 2012, Chibuwe & Ureke 2016) that digital environments constitute ideal arenas for the development of resistance thanks to their wide reach and their ability to mobilize people around common themes. However, much of the research in this area has targeted organized resistance fueled by political or ethnic groups. In this paper I argue that resistance is an emerging process that does not necessarily stem within political contexts or from open choice, but can develop within interactional exchanges focused on everyday life events.  Thus, what I am interested in here is in how spontaneous acts and discourses of resistance emerge in the everyday exchanges of a diverse community that was not born around a particular social or political agenda.  For this paper, I will examine exchanges that happen on the Facebook page of one of the members of the community. I will show how resistance takes many forms: from irony and jokes to the raising of serious topics, to the dissemination of information and through different discourse genres: from storytelling to the posting of pictures

Comparing learned predictiveness effects within and across compound discriminations

In four human learning experiments, we examined the extent to which learned predictiveness depends upon direct comparison between relatively good and poor predictors. Participants initially solved (1) linear compound discriminations in which one or both of the stimuli in each compound were predictive of the correct outcome, (2) biconditional discriminations where only the configurations of the stimuli were predictive of the correct outcome, or (3) pseudo-discriminations in which no stimulus features were predictive. In each experiment, subsequent learning and test stages were used to assay changes in the associability of each stimulus brought about by its role in the initial discriminations. Although learned predictiveness effects were observed in all experiments (i.e. previously predictive cues were more readily associated with a new outcome than previously non-predictive cues), the same changes in associability were observed regardless of whether the stimulus was initially learned about in the presence of an equally predictive, more predictive, or less predictive stimulus. The results suggest that learned associability is not controlled by competitive allocation of attention, but rather by the absolute predictiveness of each individual cue.Australian Research Council, and the German Academic Exchange Service (DAAD

The structure of everyday narrative in a city market: An ethnopoetics approach

This paper considers the value of Hymesian ethnopoetics as a means of analysing everyday narrative in conditions of mobility and change. The paper offers an account of the development of ethnopoetics as a means to make visible and valorize narrative in the Native American oral tradition, and as a method of revealing culturally specific relations of form and meaning. Hymes' ethnopoetic approach viewed narrative structure as a reflection of a cultural tradition of meaning‐making. Hymes' analysis proposed that traditional narrative was a culturally shaped way of speaking, and analysis of narrative structure could reveal and recreate culture. His orientation rested on an assumption that the culture of a group was more or less stable and fixed. This paper adopts an approach to analysis based on ethnopoetics, representing everyday narrative dramatically, organized not only as lines and verses, but also as scenes and acts. Representation in scenes and acts makes visible the dynamic nature of the narrative. The paper asks whether Hymes' ground‐breaking work on ethnopoetics still has currency and purchase in 21st‐century conditions of mobility, change, and unpredictability. Analysis of everyday narrative in a city market concludes that, notwithstanding the complexity of notions of 'culture' and 'language' in such conditions, ethnopoetics can be productively applied to everyday contexts for the analysis of narrative

Prognostic Role of Neutrophil, Monocyte and Platelet to Lymphocyte Ratios in Advanced Ovarian Cancer According to the Time of Debulking Surgery

Despite a multimodal radical treatment, mortality of advanced epithelial ovarian cancer (AEOC) remains high. Host-related factors, such as systemic inflammatory response and its interplay with the immune system, remain underexplored. We hypothesized that the prognostic impact of this response could vary between patients undergoing primary debulking surgery (PDS) and those undergoing interval debulking surgery (IDS). Therefore, we evaluated the outcomes of two surgical groups of newly diagnosed AEOC patients according to the neutrophil, monocyte and platelet to lymphocyte ratios (NLR, MLR, PLR), taking median ratio values as cutoffs. In the PDS group (n = 61), low NLR and PLR subgroups showed significantly better overall survival (not reached (NR) vs. 72.7 months, 95% confidence interval [CI]: 40.9-95.2, p = 0.019; and NR vs. 56.1 months, 95% CI: 40.9-95.2, p = 0.004, respectively) than those with high values. Similar results were observed in progression free survival. NLR and PLR-high values resulted in negative prognostic factors, adjusting for residual disease, BRCA1/2 status and stage (HR 2.48, 95% CI: 1.03-5.99, p = 0.043, and HR 2.91, 95% CI: 1.11-7.64, p = 0.03, respectively). In the IDS group (n = 85), ratios were not significant prognostic factors. We conclude that NLR and PLR may have prognostic value in the PDS setting, but none in IDS, suggesting that time of surgery can modulate the prognostic impact of baseline complete blood count (CBC)

Study of breast cancer incidence in patients of lymphangioleiomyomatosis

The online version of this article (doi:10.1007/s10549-016-3737-8) contains supplementary material, which is available to authorized user

BCL3-rearrangements in B-cell lymphoid neoplasms occur in two breakpoint clusters associated with different diseases

The t(14;19)(q32;q13) often juxtaposes BCL3 with IGH resulting in overexpression of the gene. In contrast to other oncogenic translocations, BCL3-rearrangement (BCL3-R) has been associated with a broad spectrum of lymphoid neoplasms. Here we report an integrative whole-genome sequence, transcriptomic, and DNA methylation analysis of 13 lymphoid neoplasms with BCL3-R. The resolution of the breakpoints at single base-pair revealed that they occur in two clusters at 5' (n=9) and 3' (n=4) regions of BCL3 associated with two different biological and clinical entities. Both breakpoints were mediated by aberrant class switch recombination of the IGH locus. However, the 5' breakpoints (upstream) juxtaposed BCL3 next to an IGH enhancer leading to overexpression of the gene whereas the 3' breakpoints (downstream) positioned BCL3 outside the influence of the IGH and were not associated with its expression. Upstream BCL3-R tumors had unmutated IGHV, trisomy 12, and mutated genes frequently seen in CLL but had an atypical CLL morphology, immunophenotype, DNA methylome, and expression profile that differ from conventional CLL. In contrast, downstream BCL3-R neoplasms were atypical splenic or nodal marginal zone lymphomas (MZL) with mutated IGHV, complex karyotypes and mutated genes typical of MZL. Two of the latter 4 tumors transformed to a large B-cell lymphoma. We designed a novel FISH assay that recognizes the two different breakpoints and validated these findings in 17 independent tumors. Overall, upstream or downstream breakpoints of BCL3-R are mainly associated with two subtypes of lymphoid neoplasms with different (epi)genomic, expression, and clinicopathological features resembling atypical CLL and MZL, respectively

Lymphangioleiomyomatosis biomarkers linked to lung metastatic potential and cell stemness

Lymphangioleiomyomatosis (LAM) is a rare lung-metastasizing neoplasm caused by the proliferation of smooth muscle-like cells that commonly carry loss-of-function mutations in either the tuberous sclerosis complex 1 or 2 (TSC1 or TSC2) genes. While allosteric inhibition of the mechanistic target of rapamycin (mTOR) has shown substantial clinical benefit, complementary therapies are required to improve response and/or to treat specific patients. However, there is a lack of LAM biomarkers that could potentially be used to monitor the disease and to develop other targeted therapies. We hypothesized that the mediators of cancer metastasis to lung, particularly in breast cancer, also play a relevant role in LAM. Analyses across independent breast cancer datasets revealed associations between low TSC1/2 expression, altered mTOR complex 1 (mTORC1) pathway signaling, and metastasis to lung. Subsequently, immunohistochemical analyses of 23 LAM lesions revealed positivity in all cases for the lung metastasis mediators fascin 1 (FSCN1) and inhibitor of DNA binding 1 (ID1). Moreover, assessment of breast cancer stem or luminal progenitor cell biomarkers showed positivity in most LAM tissue for the aldehyde dehydrogenase 1 (ALDH1), integrin-ß3 (ITGB3/CD61), and/or the sex-determining region Y-box 9 (SOX9) proteins. The immunohistochemical analyses also provided evidence of heterogeneity between and within LAM cases. The analysis of Tsc2-deficient cells revealed relative over-expression of FSCN1 and ID1; however, Tsc2-deficient cells did not show higher sensitivity to ID1-based cancer inhibitors. Collectively, the results of this study reveal novel LAM biomarkers linked to breast cancer metastasis to lung and to cell stemness, which in turn might guide the assessment of additional or complementary therapeutic opportunities for LAM