Antifungals In Eye Infections: Drugs And Routes Of Administration

Treatment of fungal eye infections represents a challenge to the ophthalmology practice. For an adequate therapeutic response, besides correct drug choice, it is necessary an effectively administration. This script gathers information about the major antifungal drugs used in eye infections, their concentrations and main administration routes.722132141Leber, T.H., Keratomycosis aspergillina als ursache von hypopyonkeratites (1879) Graefes Ach Clin Exp Ophthalmol, 25, pp. 285-301Alfonso, E.C.G.A., Miller, D., Fungal keratitis (2011) Cornea: fundamentals, diagnosis and management, , In: Krachmer JH, Mannis MJ, Holland EJ, editors.3rd ed. 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CICATRIZAÇÃO SECUNDÁRIA EM FERIDAS DERMOEPIDÉRMICAS TRATADAS COM ÁCIDOS GRAXOS ESSENCIAIS, VITAMINAS A e E, LECITINA DE SOJA E IODO POLIVINILPIRROLIDONA EM CÃES

Com o objetivo de avaliar os efeitos da solução contendo ácidos graxos essenciais, lecitina de soja e vitaminas A e E sobre a cicatrização secundária de feridas dermoepidérmicas, observou-se a evolução da reparação tecidual em nove cães machos, SRD, com idade variando entre três e cinco anos e peso de 12 kg em média. Para isto, em cada paciente foram produzidos dois defeitos de pele, medindo 6cm de altura (sentido dorsoventral) x 4cm de largura (sentido craniocaudal) em ambas as faces laterais do tórax e do abdome, sendo que nas lesões do lado esquerdo procedeu-se a avaliação física e mensuração diária, enquanto que nas feridas do lado direito, realizou-se biópsia incisional a cada dois dias. Nas lesões abdominais esquerdas, tratadas com ácidos graxos e curativos úmidos com solução fisiológica 0,9%, tanto macro como microscopicamente, observou-se inflamação aguda durante os três primeiros dias, sendo esta seguida pelos eventos de granulação, contração e reepitelização completa até o 25º dia. Nas feridas torácicas esquerdas, expostas ao iodo polivinilpirrolidona e curativos úmidos, constatouse a predominância dos eventos inflamatórios agudos por sete dias, seguida dos fenômenos proliferativos, de contração e completa reepitelização até o 31º dia pós cirúrgico. A ausência de sinais compatíveis com toxicidade sistêmica e a mais rápida cicatrização das lesões tratadas com ácidos graxos, permitem a indicação desta solução para o tratamento de feridas abertas dermoepidérmicas, em cães. Secondary cicatrization in dermoepidermal wounds treated with essential fatty acids, vitamins A and E, soy lecithin and polynylpyrrolidone-iodine in dogs Abstract The effects of a solution containing essential fatty acids, soy lecithin and vitamins A and E in the healing of canine second intention dermoepidermal wounds were evaluated. In order to observe evolution of the tissue repair. Nine male, mixed breed dogs, with age varying between three and five years and average weight of 12 kg, were used in the experiment. Skin wounds were surgically performed in each dog. Two defects (6 x 4 cm) were performed in both thoracic and abdominal lateral faces of the animals. Daily physical evaluation and measurement were analyzed in the lesions situated on the left side, while incisional biopsy every other day was performed in the right side lesions. The left abdominal lesions, treated with fatty acids and humid curatives with physiologic solution 0.9 %, showed macro and microscopic changes such as acute inflammation during the firs three days. After this period and until the 25th day, granulation tissue followed by contraction events and total reepitelization were observed. The left thoracic lesions, treated with povidone-iodine and humid curatives, showed predominance of acute inflammatory events during the first seven days; these events were followed by proliferative and contraction events and by the total recovery of the epithelial surface until the 31st day after the surgery. In conclusion, the absence of compatible signs with systemic toxicity and the fastest healing of the lesions treated with fatty acids allow its indication for dermoepidermal wound treatment in dogs

Two-band Eliashberg equations and the experimental Tc of the diboride Mg1-xAlxB2

The variation of the superconducting critical temperature Tc as a function of x in the diboride Mg1-xAlxB2 has been studied in the framework of the two-bands Eliashberg theory and traditional phonon coupling mechanism. We have solved the two-bands Eliashberg equations using first-principle calculations or simple assumptions for the variation of the relevant physical quantities. We have found that the experimental Tc curve can be explained only if the Coulomb pseudopotential changes with x by tuning the Fermi level toward the sigma band edge. In polycrystal samples the x dependence of the sigma and pi-band gap has been found and is in agreement with experiments.Comment: 6 pages, 7 figure

Identification of a spur-like structure in the Milky Way's Sagittarius arm

Galaxie

Study of dielectron production in C+C collisions at 1 AGeV

The emission of e+e- pairs from C+C collisions at an incident energy of 1 GeV per nucleon has been investigated. The measured production probabilities, spanning from the pi0-Dalitz to the rho/omega! invariant-mass region, display a strong excess above the cocktail of standard hadronic sources. The bombarding-energy dependence of this excess is found to scale like pion production, rather than like eta production. The data are in good agreement with results obtained in the former DLS experiment.Comment: submitted to Physics Letters