The regulation of differentiation in mesenchymal stem cells

Peer reviewedPublisher PD

Immunostaining of skeletal tissues

Peer reviewedPreprin

Mesenchymal stem cells for management of rheumatoid arthritis : immune modulation, repair or both?

The authors are grateful for support to their research from Arthritis Research UK (grants 19271, 19429, 19667, 20050, 20775) and the Medical Research Council (grant no. MR/L020211/1)Peer reviewedPostprin

Effective fire extinguishing systems for lithium-ion battery

Lithium-ion batteries are a popular choice of power source for a variety of energy and power demanding applications for both stationary applications and electromobility. Among electrochemical storage systems, Lithium-ion batteries were found to be promising candidate, due to their high power and high energy density. In order to assemble high power batteries for plug-in hybrid electric vehicles and pure electric vehicles, several hundreds of large-format Lithium-ion cells will be required, and even more cells for power/energy demanding stationary applications. However, safety remains a significant concern, as battery failure leads to ejection of hazardous materials and rapid heat release. The failure of a single cell can generate a large amount of heat which can then initiate, in the worst case, the thermal runaway of neighbouring cells, leading to failure throughout the battery pack. The heat accumulation can also run into the venting of a cell, with the emission of flammable organic solvent inside the battery pack. Battery failure can be initiated via a number of different abuse scenarios, such as overheating, overcharging, puncture/crushing, water immersion, or external short circuit. Development of effective mitigation strategies necessitates a study on battery failure events and a better understanding of important characteristics relating to safety, such as heat release, hazardous materials ejection, and thermal propagation. On the other hand, when a fire event is initiated, proper intervention strategies have to be defined in order to avoid it becoming catastrophic. In this paper are reported the results of thermal abuse tests on single Lithium-ion cells and a battery pack. The tests were performed with the technical equipment and resources of National Fire Corps. Screening tests for battery fire extinguishing agents were also performed. The effectiveness of an agent was evaluated through experiments on the cooling effect of fire extinguishing agents. Among the various agents, water and foam were found to be the most effective

Yes-associated protein (YAP) is a negative regulator of chondrogenesis in mesenchymal stem cells

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Acknowledgements The authors would like to thank Dr Marius Sudol for the hYAP plasmids (obtained through Addgene), Dr Pete Zammit for the pMSCV-IRES-eGFP plasmid, Dr Robert Judson for subcloning the hYAP cDNAs into the pMSCV-IRES-eGFP plasmid, Dr Lynda Erskine for the provision of mouse embryo samples, and Professor Jimmy Hutchison and the Orthopaedics Department at the Aberdeen Royal Infirmary for the provision of human tissue samples. The authors are also grateful to Denise Tosh and Susan Clark for excellent technical support. This work was funded by Arthritis Research UK (grant 19429).Peer reviewedPublisher PD

Connecting Europe Facility: Le Autorità portuali e la massimizzazione dell’effetto leva

L’articolo analizza gli effetti dell’entrata in vigore del nuovo Regolamento delle TEN-T e del Meccanismo per Collegare l’Europa (Connecting Europe Facility- CEF) sulla pianificazione e gestione delle infrastrutture di trasporto. In particolare vengono analizzate le principali priorità per le Autorità portuali Italiane nella gestione e nell’adozione di politiche con riferimento al cambiamento istituzionale che prevedibilmente apporteranno questi Regolamenti

Osteoarthritis year in review 2023 : Biology

Open Access via the Elsevier agreementPeer reviewe

BBN bounds on active-sterile neutrino mixing

Nucleosynthesis restrictions on mixing of active neutrinos with possible sterile ones are obtained with the account of experimentally determined mixing between all active neutrinos. The earlier derived bounds, valid in the absence of active-active mixing, are reanalyzed and significant difference is found in the resonance case. The results are obtained both analytically and numerically by solution of complete system of integro-differential kinetic equations. A good agreement between analytical and numerical approaches is demonstrated. A role of possibly large cosmological lepton asymmetry is discussed.Comment: 38 pages, 10 figure