New Proposal to Iran: Will It Be Enough to Defuse the Nuclear Crisis?

This BASIC Note assesses the progress of transatlantic diplomacy toward Iran on nuclear issues. On June 6, Iran was presented with a revised package of incentives to persuade it to curb its uranium enrichment program. The authors argued previously that the earlier E3/EU proposal was vague on incentives and heavy on demands. (See BASIC Note, August 11, 2005 at http://www.basicint.org/pubs/Notes/BN050811-IranEU.htm). In this article, the authors suggest that if the June 6 proposal had been offered a year ago (or better still two years ago), much of the recent damage to diplomatic relations between Iran and the West could have been avoided

Effective Inner Radius of Tilted Black Hole Accretion Disks

One of the primary means of determining the spin of an astrophysical black hole is by actually measuring the inner radius of a surrounding accretion disk and using that to infer the spin. By comparing a number of different estimates of the inner radius from simulations of tilted accretion disks with differing black-hole spins, we show that such a procedure can give quite wrong answers. Over the range 0 <= a/M <= 0.9, we find that, for moderately thick disks (H/r ~ 0.2) with modest tilt (15 degrees), the inner radius is nearly independent of spin. This result is likely dependent on tilt, such that for larger tilts, it may even be that the inner radius would increase with increasing spin. In the opposite limit, we confirm through numerical simulations of untilted disks that, in the limit of zero tilt, the inner radius recovers approximately the expected dependence on spin.Comment: 5 pages, 4 figures, accepted to ApJ Letter

A Church-based Diabetes Self-management Education Program for African Americans With Type 2 Diabetes

INTRODUCTION: Diabetes self-management education interventions in community gathering places have been moderately effective, but very few studies of intervention effectiveness have been conducted among African Americans with type 2 diabetes. This paper describes a church-based diabetes self-management education intervention for African Americans, a randomized controlled trial to evaluate the intervention, and baseline characteristics of study participants. METHODS: A New DAWN: Diabetes Awareness & Wellness Network was conducted among 24 churches of varying size in North Carolina. Each church recruited congregants with type 2 diabetes and designated a diabetes advisor, or peer counselor, to be part of the intervention team. Participants were enrolled at each church and randomized as a unit to either the special intervention or the minimal intervention. The special intervention included one individual counseling visit, twelve group sessions, three postcard messages from the participant's diabetes care provider, and twelve monthly telephone calls from a diabetes advisor. Baseline data included measures of weight, hemoglobin A1c, blood pressure, physical activity, dietary and diabetes self-care practices, and psychosocial factors. The study to evaluate the intervention (from enrollment visit to last follow-up) began in February 2001 and ended in August 2003. RESULTS: Twenty-four churches (with 201 total participants) were randomized. Sixty-four percent of the participants were women. On average, the participants were aged 59 years and sedentary. They had an average of 12 years of education, had been diagnosed with diabetes for 9 years, had a body mass index of 35, had a hemoglobin A1c level of 7.8%, and had a reported dietary intake of 39% of calories from fat. CONCLUSION: A New DAWN is a culturally sensitive, church-based diabetes self-management education program for African Americans with type 2 diabetes that is being evaluated for effectiveness in a randomized controlled trial. The outcomes of A New DAWN will contribute to the literature on community-based interventions for minority populations and help to inform the selection of approaches to improve diabetes care in this population

The two faces of CD73 in tumor-infiltrating lymphocytes expanded from Liposarcoma

TMP-IL, Department of Translational Molecular Pathology Department of Sarcoma Medical Oncologyhttps://openworks.mdanderson.org/sumexp22/1056/thumbnail.jp

Continuous Infusions of Meropenem in Ambulatory Care: Clinical Efficacy, Safety and Stability

Objectives: Concerns regarding the clinical impact of meropenem instability in continuous infusion (CI) devices may contribute to inconsistent uptake of this method of administration across outpatient parenteral antimicrobial therapy (OPAT) services. Methods: We retrospectively reviewed the clinical efficacy and safety of CIs of meropenem in two Australian tertiary hospitals and assessed its stability under simulated OPAT conditions including in elastomeric infusion devices containing 1% (2.4 g) or 2% (4.8 g) concentrations at either ‘room temperature’ or ‘cooled’ conditions. Infusate aliquots were assayed at different time-points over 24 hours. Results: Forty-one (82%) of 50 patients had clinical improvement or were cured. Adverse patient outcomes including hemato-, hepato- and nephrotoxicity were infrequent. Cooled infusers with 1% meropenem had a mean 24-hour recovery of 90.3%. Recoveries of 1% and 2% meropenem at room temperature and 2% under cooled conditions were 88%, 83% and 87%, respectively. Patients receiving 1% meropenem are likely to receive >95% of the maximum deliverable dose (MDD) over a 24-hour period whilst patients receiving 2% meropenem should receive 93% and 87% of the MDD under cooled and room temperature conditions, respectively. Conclusions: Meropenem infusers are likely to deliver ~95% MDD and maintain effective plasma concentrations throughout the dosing period. These data reflect our local favourable clinical experience with eropenem CIs

Emergent Mesoscale Phenomena in Magnetized Accretion Disc Turbulence

We study how the structure and variability of magnetohydrodynamic (MHD) turbulence in accretion discs converge with domain size. Our results are based on a series of vertically stratified local simulations, computed using the Athena code, that have fixed spatial resolution, but varying radial and azimuthal extent (from \Delta R = 0.5H to 16H, where H is the vertical scale height). We show that elementary local diagnostics of the turbulence, including the Shakura-Sunyaev {\alpha} parameter, the ratio of Maxwell stress to magnetic energy, and the ratio of magnetic to fluid stresses, converge to within the precision of our measurements for spatial domains of radial size Lx \geq 2H. We obtain {\alpha} = 0.02-0.03, consistent with recent results. Very small domains (Lx = 0.5H) return anomalous results, independent of spatial resolution. The convergence with domain size is only valid for a limited set of diagnostics: larger spatial domains admit the emergence of dynamically important mesoscale structures. In our largest simulations, the Maxwell stress shows a significant large scale non-local component, while the density develops long-lived axisymmetric perturbations (zonal flows) at the 20% level. Most strikingly, the variability of the disc in fixed-sized patches decreases strongly as the simulation volume increases. We find generally good agreement between our largest local simulations and global simulations with comparable spatial resolution. There is no direct evidence that the presence of curvature terms or radial gradients in global calculations materially affect the turbulence, except to perhaps introduce an outer radial scale for mesoscale structures. The demonstrated importance of mean magnetic fields, seen in both large local and global simulations implies that the growth and saturation of these fields is likely of critical importance for the evolution of accretion discs. (abridged)Comment: 18 pages, 20 figures, accepted to MNRA

Sudden Infant Death Syndrome (SIDS) and the routine otoacoustic emission infant hearing screening test: an epidemiological retrospective case-control study

Objectives To investigate whether decreased otoacoustic emission (OAE) signal recordings in the right ear are associated with an increased risk of sudden infant death syndrome (SIDS) and to monitor any temporal changes in risk factors. Design Retrospective case-control study. Setting Telephone interviews with families recruited in England between July 2016 and October 2017 who experienced the unexpected death of a child <4 years old since 2008 and control families recruited from maternity wards in Bristol and Birmingham. Participants We recruited 91 (89%) of the 102 bereaved families who made initial contact, 64 deaths were under 1 year (sudden unexpected death in infancy) of which 60 remained unexplained (SIDS). Of the 220 control families, 194 (88%) follow-up interviews were conducted. We had analysable hearing data for 24 SIDS infants (40%) and 98 controls (51%). Results OAE signals were marginally increased rather than decreased among SIDS infants for the right ear, especially at lower frequencies, but not significantly so. The strongest predictors of SIDS were bed-sharing in hazardous (infant sleeping next to a carer who smoked, drank alcohol or slept on a sofa) circumstances (35% vs 3% controls, p<0.0001), infants found prone (33% vs 3% controls, p<0.0001) and infants whose health in the final week was â € not good' (53% vs 9% controls, p<0.0001). The prevalence of maternal smoking during pregnancy among both SIDS mothers (20%) and controls (10%) was much lower than previous studies. Conclusions Hearing data were difficult to obtain; larger numbers would be needed to determine if asymmetrical differences between the right and left ear were a marker for SIDS. A national prospective registry for monitoring and a renewed campaign to a new generation of parents needs to be considered underlining the initial message to place infants on their backs for sleep and the more recent message to avoid bed-sharing in hazardous circumstances

Social Cohesion, Structural Holes, and a Tale of Two Measures

EMBARGOED - author can archive pre-print or post-print on any open access repository after 12 months from publication. Publication date is May 2013 so embargoed until May 2014.This is an author’s accepted manuscript (deposited at arXiv arXiv:1211.0719v2 [physics.soc-ph] ), which was subsequently published in Journal of Statistical Physics May 2013, Volume 151, Issue 3-4, pp 745-764. The final publication is available at link.springer.com http://link.springer.com/article/10.1007/s10955-013-0722-