Multi-spatial-mode effects in squeezed-light-enhanced interferometric gravitational wave detectors

Proposed near-future upgrades of the current advanced interferometric gravitational wave detectors include the usage of frequency dependent squeezed light to reduce the current sensitivity-limiting quantum noise. We quantify and describe the degradation effects that spatial mode-mismatches between optical resonators have on the squeezed field. These mode-mismatches can to first order be described by scattering of light into second-order Gaussian modes. As a demonstration of principle, we also show that squeezing the second-order Hermite-Gaussian modes $\mathrm{HG}_{02}$ and $\mathrm{HG}_{20}$, in addition to the fundamental mode, has the potential to increase the robustness to spatial mode-mismatches. This scheme, however, requires independently optimized squeeze angles for each squeezed spatial mode, which would be challenging to realise in practise.Comment: 10 pages, 12 figure

Utilizing Urban Living Laboratories for Social Innovation

Cities have long been recognized as potential hubs of knowledge, social and cultural diversity, jobs, education, public services, and infrastructure. Alongside these opportunities, however, cities also face a changing climate, reduced availability of raw materials and natural resources, and dwindling physical space for the built environment. These challenges are accompanied by increasing disparities in income and resultant social inequalities; mounting threats to human health, well-being, and food security; growing refugee and migration influxes; and demographic changes. These concerns and associated governance challenges increase the urgency for new socially, ecologically, and culturally sensitive approaches to urban development. Such approaches need not only to reduce human vulnerability and environmental footprints, but also to build social cohesion and support ecological sustainability, cultural integration, and the establishment of a shared identity between citizens within a just system of distribution and access to urban resources and wealth

Nature-Based Solutions and Sustainable Urban Planning in the European Environmental Policy Framework: Analysis of the State of the Art and Recommendations for Future Development

Sustainable urban planning (SUP) is crucial in the development of sustainable cities, as also underlined by the New Urban Agenda. Nature-based solutions (NBS) are increasingly being recognized for their potential to offer multiple benefits that are necessary in order to cope with present and future urban challenges. The European policy framework, including the recently released European Green Deal, could strongly boost the role and recognition of NBS and SUP as drivers of sustainable and inclusive urban transition. Through a content analysis of current environmental European policies, strategies and agreements, this paper provides (i) an overview of the state of the art of the environmental European policy framework and the recognized role of NBS and SUP in reaching defined objectives, and (ii) insights on where NBS and SUP could play a larger role within this framework. On this basis, the paper identifies gaps and develops recommendations for a better integration of such concepts into the current framework

An extension of the Minute Virus of Mice tissue tropism

AbstractWell-defined tissue tropism makes Autonomous Parvoviruses a valuable model for studies of virus–cell interactions and gene therapy research. We developed a new Minute Virus of Mice variant, different from the known prototype (MVMp) and immunosuppressive (MVMi) strains. The new virus variant, designated F1, was isolated from the culture of semi-permissive Fisher Rat Fibroblasts, F111, infected with MVMp. The F1 genome carried point mutations in regions known to determine the mutually restricted host ranges of MVMp and MVMi. In F111 cells, F1 cytotoxicity, gene expression and multiplication were significantly higher compared to MVMp. Conversely the wild-type virus propagated in MVMp-permissive cells more efficiently than the F1. Reversion of the F1-specific mutations to wild-type MVMp sequence, following reverse-passaging of the mutant virus in MVMp-permissive cells, confirmed a specific adaptation of the F1 virus to F111 cells. Considerable divergence in tissue specificities between the wild-type and mutant viruses was demonstrated in vivo

Exploring factors affecting individual GPS-based activity space and how researcher-defined food environments represent activity space, exposure and use of food outlets

Background Obesity remains one of the most challenging public health issues of our modern time. Despite the face validity of claims for influence, studies on the causes of obesity have reported the influence of the food environment to be inconsistent. This inconsistency has been attributed to the variability of measures used by researchers to represent the food environments—Researcher-Defined Food Environments (RDFE) like circular, street-network buffers, and others. This study (i.) determined an individual’s Activity Space (AS) (ii.) explored the accuracy of the RDFE in representing the AS, (iii.) investigated the accuracy of the RDFE in representing actual exposure, and (iv.) explored whether exposure to food outlet reflects the use of food outlets. Methods Data were collected between June and December 2018. A total of 65 participants collected Global Positioning System (GPS) data, kept receipt of all their food purchases, completed a questionnaire about their personal information and had their weight and height measured. A buffer was created around the GPS points and merged to form an AS (GPS-based AS). Results Statistical and geospatial analyses found that the AS size of participants working away from home was positively related to the Euclidean distance from home to workplace; the orientation (shape) of AS was also influenced by the direction of workplace from home and individual characteristics were not predictive of the size of AS. Consistent with some previous studies, all types and sizes of RDFE variably misrepresented individual exposure in the food environments. Importantly, the accuracy of the RDFE was significantly improved by including both the home and workplace domains. The study also found no correlation between exposure and use of food outlets. Conclusions Home and workplace are key activity nodes in modelling AS or food environments and the relationship between exposure and use is more complex than is currently suggested in both empirical and policy literature

Support and compliance with 20 mph speed limits in Great Britain

© 2015 Elsevier Ltd. All rights reserved. There are a number of challenges relating to both the support of and compliance with speed limits. The introduction of 20 mph limits in Great Britain is no exception: the recent rise in the deployment of these limits in urban settings has created a need to understand these issues in more depth. This paper reports a study undertaken by the authors that used a population wide survey of GB drivers to explore how support and compliance were interlinked. Whilst as expected many supporters said they would comply with the limits, and many opponents might not comply, more surprisingly it was also found that some supporters claimed not to comply, while some opponents of 20 mph limits were compliers. Explanations included the strong likelihood of strong moral adherence to not breaking laws amongst opponent-compliers, and self-enhancement bias amongst supporter-non-compliers. This paper explores the incidence of these effects and their implications in detail

Cognitive biases to healthy and unhealthy food words predict change in BMI

The current study explored the predictive value of cognitive biases to food cues (assessed by emotional Stroop and dot probe tasks) on weight change over a 1-year period. This was a longitudinal study with undergraduate students (N = 102) living in shared student accommodation. After controlling for the effects of variables associated with weight (e.g., physical activity, stress, restrained eating, external eating, and emotional eating), no effects of cognitive bias were found with the dot probe. However, for the emotional Stroop, cognitive bias to unhealthy foods predicted an increase in BMI whereas cognitive bias to healthy foods was associated with a decrease in BMI. Results parallel findings in substance abuse research; cognitive biases appear to predict behavior change. Accordingly, future research should consider strategies for attentional retraining, encouraging individuals to reorient attention away from unhealthy eating cues