Estilos de vida em idosas e níveis de atividade física: um estudo piloto

The International Physical Activity Questionnaire (IPAQ) is a standardized measure to estimate habitual practice of physical activities. Because of the specificity of different elderly’s life styles, and, consequently, modes of physical activity, the purpose of this pilot study was to analyze differences among ten regular gym practitioners (fitness group) (68,60±3,57 years of age) and ten Senior University students without gym practice (informal group) (71,30±5,54 years of age). The results showed that energy expenditure doesn’t depend solely on regular and controlled physical activity at a Fitness center, and that functional motor activity, as daily life active transportation and domestic and garden activities, resulted in similar energy expenditure. It’s suggested that programs combining energy expenditure and daily life motor activities is a good solution for quality of life enhancement, and an alternative to more standardized fitness practices.O Questionário Internacional de Atividade Física (IPAQ) é uma medida padronizada para estimar a prática habitual de atividades físicas. A finalidade deste estudo piloto foi analisar as diferenças entre dez praticantes regulares de ginásio (68,60 ± 3,57 anos de idade) e dez estudantes de uma Universidade Sénior sem atividade física formal (grupo informal) (71,30 ± 5,54 anos de idade). Os resultados mostraram que o dispêndio energético não depende unicamente da atividade física regular e controlada num centro de Fitness, e que a atividade motora funcional, como o transporte ativo e as atividades domésticas e de jardim, resultou em gastos energéticos semelhantes. Sugere-se que programas que combinem dispêndio energético e atividades motoras de vida diária são uma boa solução para a valorização da qualidade de vida e uma alternativa a práticas de Fitness mais padronizadas.info:eu-repo/semantics/publishedVersio

Strategic Management and Retention of Talent: Challenges in the Portuguese Army

Organizations are made up of people, their most important asset. The Armed Forces are no exception in this context, quite the opposite. Despite all the developments in military equipment, especially in the last century, the human component continues to be a determining factor in the overwhelming majority of the weapons systems. The investments that have been made to the military, in terms of academic, technical and operational training, have contributed to increasing their skills and abilities in a professional career that, today, is facing even more asymmetrical challenges. Different levels of motivation, different career aspirations linked to organizational constraints and different economic contexts, have led to an increasingly difficult strategic management of human resources in the military areas, such as the Portuguese Army. This article addresses the urgency of retaining talent in the Portuguese Army, at a time when this branch of the Portuguese Armed Forces is confronted with new assignments, missions and challenges

Low-dimensional, hinged bar-code metal oxide layers and free-standing, ordered organic nanostructures from turbostratic vanadium oxide

Both low-dimensional bar-coded metal oxide layers, which exhibit molecular hinging, and free-standing organic nanostructures can be obtained from unique nanofibers of vanadium oxide (VOx). The nanofibers are successfully synthesized by a simple chemical route using an ethanolic solution of vanadium pentoxide xerogel and dodecanethiol resulting in a double bilayered laminar turbostratic structure. The formation of vanadium oxide nanofibers is observed after hydrothermal treatment of the thiol-intercalated xerogel, resulting in typical lengths in the range 2–6 µm and widths of about 50–500 nm. We observe concomitant hinging of the flexible nanofiber lamina at periodic hinge points in the final product on both the nanoscale and molecular level. Bar-coded nanofibers comprise alternating segments of organic–inorganic (thiols–VOx) material and are amenable to segmented, localized metal nanoparticle docking. Under certain conditions free-standing bilayered organic nanostructures are realized

Six-fold rotationally symmetric vanadium oxide nanostructures by a morphotropic phase transition

In this work, we report the first observation of unique hierarchical six‐fold rotational symmetrical vanadium oxide based nanocomposite synthesized by a simple chemical route and highlight the first observation of a morphotropic reconstructive phase transistion from a lamellar V2O5 to that of a single crystalline V6O11 nanostructure

Children's exposure assessment of radiofrequency fields: comparison between spot and personal measurements

Radiofrequency (RF) fields are widely used and, while it is still unknown whether children are more vulnerable to this type of exposure, it is essential to explore their level of exposure in order to conduct adequate epidemiological studies. Personal measurements provide individualized information, but they are costly in terms of time and resources, especially in large epidemiological studies. Other approaches, such as estimation of time-weighted averages (TWAs) based on spot measurements could simplify the work.; The aims of this study were to assess RF exposure in the Spanish INMA birth cohort by spot measurements and by personal measurements in the settings where children tend to spend most of their time, i.e., homes, schools and parks; to identify the settings and sources that contribute most to that exposure; and to explore if exposure assessment based on spot measurements is a valid proxy for personal exposure.; When children were 8 years old, spot measurements were conducted in the principal settings of 104 participants: homes (104), schools and their playgrounds (26) and parks (79). At the same time, personal measurements were taken for a subsample of 50 children during 3 days. Exposure assessment based on personal and on spot measurements were compared both in terms of mean exposures and in exposure-dependent categories by means of Bland-Altman plots, Cohen's kappa and McNemar test.; Median exposure levels ranged from 29.73 (in children's bedrooms) to 200.10 μW/m; 2; (in school playgrounds) for spot measurements and were higher outdoors than indoors. Median personal exposure was 52.13 μW/m; 2; and median levels of assessments based on spot measurements ranged from 25.46 to 123.21 μW/m; 2; . Based on spot measurements, the sources that contributed most to the exposure were FM radio, mobile phone downlink and Digital Video Broadcasting-Terrestrial, while indoor and personal sources contributed very little (altogether <20%). Similar distribution was observed with personal measurements. There was a bias proportional to power density between personal measurements and estimates based on spot measurements, with the latter providing higher exposure estimates. Nevertheless, there were no systematic differences between those methodologies when classifying subjects into exposure categories. Personal measurements of total RF exposure showed low to moderate agreement with home and bedroom spot measurements and agreed better, though moderately, with TWA based on spot measurements in the main settings where children spend time (homes, schools and parks; Kappa = 0.46).; Exposure assessment based on spot measurements could be a feasible proxy to rank personal RF exposure in children population, providing that all relevant locations are being measured

FooDrugs: a comprehensive food–drug interactions database with text documents and transcriptional data

Food–drug interactions (FDIs) occur when a food item alters the pharmacokinetics or pharmacodynamics of a drug. FDIs can be clinically relevant, as they can hamper or enhance the therapeutic effects of a drug and impact both their efficacy and their safety. However, knowledge of FDIs in clinical practice is limited. This is partially due to the lack of resources focused on FDIs. Here, we describe FooDrugs, a database that centralizes FDI knowledge retrieved from two different approaches: a natural processing language pipeline that extracts potential FDIs from scientific documents and clinical trials and a molecular similarity approach based on the comparison of gene expression alterations caused by foods and drugs. FooDrugs database stores a total of 3 430 062 potential FDIs, with 1 108 429 retrieved from scientific documents and 2 321 633 inferred from molecular data. This resource aims to provide researchers and clinicians with a centralized repository for potential FDI information that is free and easy to use

os números e as reconfigurações

UIDB/04647/2020 UIDP/04647/2020As Forças Armadas portuguesas confrontam-se com um problema clássico das organizações militares: atrair, formar, reter e preparar a saída dos homens e mulheres que compõem a força. Problema clássico, porém, sempre reatualizado na confluência das mudanças globais repercutidas no setor da Defesa e respetivos contextos sociais e políticos. O presente artigo descreve os movimentos de saída da atividade, por via da passagem à reserva/reforma dos militares de carreira do Exército português. No plano teórico convocam-se modelos da profissão militar à luz dos quais tais processos adquirem sentido. O suporte empírico decorre da análise da legislação enquadrante e de dados quantitativos referentes aos militares que entre 2000 e 2016 passaram à situação de reserva/reforma, um total de 4872 indivíduos. Verifica-se que a reforma é antecedida por um período na reserva, correspondendo maioritariamente a opções individuais de antecipar a saída da carreira, especialmente quando estão iminentes alterações legislativas que afetam a condição militar. The Portuguese Armed Forces are confronted with a classic problem of military organizations: to attract, train, retain and prepare the exit of the men and women who compose the force. A classic but always updated problem, giving the confluence of global changes impacting on the Defense sector and its social and political contexts. This article focuses on the transition processes for reserve and retirement, presenting the conditions required to access these situations and a briefly introducing theoretical models of military profession in that render such processes meaningful. The empirical support is derived from the analysis of legislation and from quantitative data referring to the military that between 2000 and 2016 entered the reserve / retirement situation, 4872 individuals. Results show that retirement is preceded by a reserve period, mostly corresponding to individual options to anticipate the end of the career, especially when impending legislative amendments affect the military condition.publishersversionpublishe

"Sequential" boron neutron capture therapy (BNCT): A novel approach to BNCT for the treatment of oral cancer in the hamster cheek pouch model

In the present study the therapeutic effect and potential toxicity of the novel "“Sequential"†boron neutron capture therapy (Seq-BNCT) for the treatment of oral cancer was evaluated in the hamster cheek pouch model at the RA-3 Nuclear Reactor. Two groups of animals were treated with "Sequential"BNCT, i.e., BNCT mediated by boronophenylalanine (BPA) followed by BNCT mediated by sodium decahydrodecaborate (GB-10) either 24 h (Seq-24h-BNCT) or 48 h (Seq-48h-BNCT) later. In an additional group of animals, BPA and GB-10 were administered concomitantly [(BPA + GB-10)-BNCT]. The single-application BNCT was to the same total physical tumor dose as the "Sequential"BNCT treatments. At 28 days post-treatment, Seq-24h-BNCT and Seq-48h-BNCT induced, respectively, overall tumor responses of 95 ±2% and 91 ±3%, with no statistically significant differences between protocols. Overall response for the single treatment with (BPA + GB-10)-BNCT was 75 ±5%, significantly lower than for Seq-BNCT. Both Seq-BNCT protocols and (BPA + GB-10)-BNCT induced reversible mucositis in the dose-limiting precancerous tissue around treated tumors, reaching Grade 3/4 mucositis in 47 ±12% and 60 ±22% of the animals, respectively. No normal tissue toxicity was associated with tumor response for any of the protocols. "Sequential"BNCT enhanced tumor response without an increase in mucositis in dose-limiting precancerous tissue.Fil: Molinari, Ana Julia. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Pozzi, Emiliano César Cayetano. Comisión Nacional de Energía Atómica; ArgentinaFil: Monti Hughes, Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Heber, Elisa Mercedes. Comisión Nacional de Energía Atómica; ArgentinaFil: Garabalino, Marcela Alejandra. Comisión Nacional de Energía Atómica; ArgentinaFil: Thorp, Silvia Inés. Comisión Nacional de Energía Atómica; ArgentinaFil: Miller, Marcelo. Comisión Nacional de Energía Atómica; ArgentinaFil: Itoiz, María Elina. Universidad de Buenos Aires; Argentina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Aromando, Romina F.. Universidad de Buenos Aires; ArgentinaFil: Nigg, David W.. Idaho National Laboratory; Estados UnidosFil: Quintana, Jorge. Comisión Nacional de Energía Atómica; ArgentinaFil: Santa Cruz, Gustavo Alberto. Comisión Nacional de Energía Atómica; ArgentinaFil: Trivillin, Verónica Andrea. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Schwint, Amanda Elena. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Cytokine-induced megakaryocytic differentiation is regulated by genome-wide loss of a uSTAT transcriptional program.

Metazoan development is regulated by transcriptional networks, which must respond to extracellular cues including cytokines. The JAK/STAT pathway is a highly conserved regulatory module, activated by many cytokines, in which tyrosine-phosphorylated STATs (pSTATs) function as transcription factors. However, the mechanisms by which STAT activation modulates lineage-affiliated transcriptional programs are unclear. We demonstrate that in the absence of thrombopoietin (TPO), tyrosine-unphosphorylated STAT5 (uSTAT5) is present in the nucleus where it colocalizes with CTCF and represses a megakaryocytic transcriptional program. TPO-mediated phosphorylation of STAT5 triggers its genome-wide relocation to STAT consensus sites with two distinct transcriptional consequences, loss of a uSTAT5 program that restrains megakaryocytic differentiation and activation of a canonical pSTAT5-driven program which includes regulators of apoptosis and proliferation. Transcriptional repression by uSTAT5 reflects restricted access of the megakaryocytic transcription factor ERG to target genes. These results identify a previously unrecognized mechanism of cytokine-mediated differentiation.Work in the Green lab is supported by Bloodwise (grant ref. 13003), the Wellcome Trust (grant ref. 104710/Z/14/Z), the Medical Research Council, the Kay Kendall Leukaemia Fund, the Cambridge NIHR Biomedical Research Center, the Cambridge Experimental Cancer Medicine Centre, the Leukemia and Lymphoma Society of America (grant ref. 07037), and a core support grant from the Wellcome Trust and MRC to the Wellcome Trust‐Medical Research Council Cambridge Stem Cell Institute. Hyun Jung Park was supported by postdoctoral fellowships from the EMBO and the Human Frontier Science Program