Generating Information-Diverse Microwave Speckle Patterns Inside a Room at a Single Frequency With a Dynamic Metasurface Aperture

We demonstrate that dynamic metasurface apertures (DMAs) are capable of generating a multitude of highly uncorrelated speckle patterns in a typical residential environment at a single frequency. We use a DMA implemented as an electrically-large cavity excited by a single port and loaded with many individually-addressable tunable metamaterial radiators. We placed such a DMA in one corner of a plywood-walled L-shape room transmitting microwave signals at 19 GHz as we changed the tuning states of the metamaterial radiators. In another corner, in the non-line-of-sight of the DMA, we conducted a scan of the field generated by the DMA. For comparison, we also performed a similar test where the DMA was replaced by a simple dipole antenna with fixed pattern but generating a signal that spanned 19-24 GHz. Using singular value decomposition of the scanned data, we demonstrate that the DMA can generate a multitude of highly uncorrelated speckle patterns at a single frequency. In contrast, a dipole antenna with a fixed pattern can only generate such a highly uncorrelated set of patterns when operating over a large bandwidth. The experimental results of this paper suggest that DMAs can be used to capture a diversity of information at a single frequency which can be used for single frequency computational imaging systems, NLOS motion detection, gesture recognition systems, and more

Nonlocal quantum heat engines made of hybrid superconducting devices

We discuss a quantum thermal machine that generates power from a thermally driven double quantum dot coupled to normal and superconducting reservoirs. Energy exchange between the dots is mediated by electron-electron interactions. We can distinguish three main mechanisms within the device operation modes. In the Andreev tunneling regime, energy flows in the presence of coherent superposition of zero- and two-particle states. Despite the intrinsic electron-hole symmetry of Andreev processes, we find that the heat engine efficiency increases with increasing coupling to the superconducting reservoir. The second mechanism occurs in the regime of quasiparticle transport. Here we obtain large efficiencies due to the presence of the superconducting gap and the strong energy dependence of the electronic density of states around the gap edges. Finally, in the third regime there exists a competition between Andreev processes and quasiparticle tunneling. Altogether, our results emphasize the importance of both pair tunneling and structured band spectrum for an accurate characterization of the heat engine properties in normal-superconducting coupled dot system

Generating Information-Diverse Microwave Speckle Patterns Inside a Room at a Single Frequency With a Dynamic Metasurface Aperture

We demonstrate that dynamic metasurface apertures (DMAs) are capable of generating a multitude of highly uncorrelated speckle patterns in a typical residential environment at a single frequency. We use a DMA implemented as an electrically-large cavity excited by a single port and loaded with many individually-addressable tunable metamaterial radiators. We placed such a DMA in one corner of a plywood-walled L-shape room transmitting microwave signals at 19 GHz as we changed the tuning states of the metamaterial radiators. In another corner, in the non-line-of-sight of the DMA, we conducted a scan of the field generated by the DMA. For comparison, we also performed a similar test where the DMA was replaced by a simple dipole antenna with fixed pattern but generating a signal that spanned 19-24 GHz. Using singular value decomposition of the scanned data, we demonstrate that the DMA can generate a multitude of highly uncorrelated speckle patterns at a single frequency. In contrast, a dipole antenna with a fixed pattern can only generate such a highly uncorrelated set of patterns when operating over a large bandwidth. The experimental results of this paper suggest that DMAs can be used to capture a diversity of information at a single frequency which can be used for single frequency computational imaging systems, NLOS motion detection, gesture recognition systems, and more

Stability and flexibility of odor representations in the mouse olfactory bulb

Dynamic changes in sensory representations have been basic tenants of studies in neural coding and plasticity. In olfaction, relatively little is known about the dynamic range of changes in odor representations under different brain states and over time. Here, we used time-lapse in vivo two-photon calcium imaging to describe changes in odor representation by mitral cells, the output neurons of the mouse olfactory bulb. Using anesthetics as a gross manipulation to switch between different brain states (wakefulness and under anesthesia), we found that odor representations by mitral cells undergo significant re-shaping across states but not over time within state. Odor representations were well balanced across the population in the awake state yet highly diverse under anesthesia. To evaluate differences in odor representation across states, we used linear classifiers to decode odor identity in one state based on training data from the other state. Decoding across states resulted in nearly chance-level accuracy. In contrast, repeating the same procedure for data recorded within the same state but in different time points, showed that time had a rather minor impact on odor representations. Relative to the differences across states, odor representations remained stable over months. Thus, single mitral cells can change dynamically across states but maintain robust representations across months. These findings have implications for sensory coding and plasticity in the mammalian brain

Do professionals change their communication behaviours following a training in hypnosis-derived communication? : a feasibility study in pediatric oncology

Objectives The purpose of this study was to test the feasibility of a training in hypnotic communication techniques (HCTech) for pediatric nurses to prevent procedural pain and distress in children during venipunctures. Specifically, this study aimed to (1) assess nurses’ mastery of HCTech and (2) nurses’ experience regarding the training program. Methods Participants were 6 female pediatric nurses and 33 of their cancer patients. Nurses took part in a 4-day theoretical and practical training in HCTech. Venipuncture procedures were video-recorded and assessed to evaluate nurses’ mastery of HCTech using a standardized scale. Pre-training use of HCTech was compared with post-training and follow-up for the entire nurse sample and across nurses with the same patients (109 nurse-patient interactions). After the follow-up, nurses were questioned about their experience in regards to the training and activities (themes and practice). Results Results showed medium pre-post changes in hypnotic communication behaviours (pre-post d = 0.74), with changes maintaining at follow-up (pre-follow-up d = 0.97). Interviews transcripts’ analyses revealed moderate levels of motivation and satisfaction regarding the training content and format. Nurses suggested to emphasize on the practice of HCTech in a noisy outpatient clinic as well as offer more practical exercises. Conclusion A 4-day training in hypnotic communication techniques translated into the use of HCTech by nurses practicing in pediatric oncology when comparing the same dyads at baseline, post-training and follow-up. Results support further refinement and suggest nurses could be trained to prevent pain and distress with hypnosis-derived communication strategies

Does practising hypnosis-derived communication techniques by oncology nurses translate into reduced pain and distress in their patients? : an exploratory study

Objectives: To explore the effects of a hypnotic communication (HC) training for pediatric nurses in decreasing patients’ pain and distress during venipunctures. Methods: A 4- day theoretical and practical HC training was offered to 5 pediatric oncology nurses. The effects of HC were tested with 22 young cancer patients (13 girls, 9 boys, 10±4 years) over 4 timepoints, with 88 encounters being video-recorded and coded in stable professional-patient dyads. Patients’ pain and distress were rated by patients and parents with visual analogue scales and coded from recordings using the Faces, Legs, Activity, Cry and Consolability (FLACC) scale. Results: We observed a significant decrease in pre-post distress reported by parents (d=0.45, p=0.046). Two (out of 5) nurses with higher skills acquisition had larger reduction in patients’ self-reported pain (d=1.03, p=0.028), parents perceived pain (d=1.09, p=0.042), distress (d=1.05, p=0.043) as well as observed pain (d=1.22 p=0.025). Favorable results on pain and distress did not maintain at follow-up. Conclusion and clinical implications: Training nurses in HC may translate into improved pain and distress in patients, both self-rated and observed provided that skills are used in practice. HC training is a promising non-pharmacological intervention to address pain in pediatrics

The Effect of Cone Opsin Mutations on Retinal Structure and the Integrity of the Photoreceptor Mosaic

Purpose. To evaluate retinal structure and photoreceptor mosaic integrity in subjects with OPN1LW and OPN1MW mutations. Methods. Eleven subjects were recruited, eight of whom have been previously described. Cone and rod density was measured using images of the photoreceptor mosaic obtained from an adaptive optics scanning light ophthalmoscope (AOSLO). Total retinal thickness, inner retinal thickness, and outer nuclear layer plus Henle fiber layer (ONL+HFL) thickness were measured using cross-sectional spectral-domain optical coherence tomography (SD-OCT) images. Molecular genetic analyses were performed to characterize the OPN1LW/OPN1MW gene array. Results. While disruptions in retinal lamination and cone mosaic structure were observed in all subjects, genotype-specific differences were also observed. For example, subjects with “L/M interchange” mutations resulting from intermixing of ancestral OPN1LW and OPN1MW genes had significant residual cone structure in the parafovea (∼25% of normal), despite widespread retinal disruption that included a large foveal lesion and thinning of the parafoveal inner retina. These subjects also reported a later-onset, progressive loss of visual function. In contrast, subjects with the C203R missense mutation presented with congenital blue cone monochromacy, with retinal lamination defects being restricted to the ONL+HFL and the degree of residual cone structure (8% of normal) being consistent with that expected for the S-cone submosaic. Conclusions. The photoreceptor phenotype associated with OPN1LW and OPN1MW mutations is highly variable. These findings have implications for the potential restoration of visual function in subjects with opsin mutations. Our study highlights the importance of high-resolution phenotyping to characterize cellular structure in inherited retinal disease; such information will be critical for selecting patients most likely to respond to therapeutic intervention and for establishing a baseline for evaluating treatment efficacy

Long-term treatment with responsive brain stimulation in adults with refractory partial seizures.

OBJECTIVE: The long-term efficacy and safety of responsive direct neurostimulation was assessed in adults with medically refractory partial onset seizures. METHODS: All participants were treated with a cranially implanted responsive neurostimulator that delivers stimulation to 1 or 2 seizure foci via chronically implanted electrodes when specific electrocorticographic patterns are detected (RNS System). Participants had completed a 2-year primarily open-label safety study (n = 65) or a 2-year randomized blinded controlled safety and efficacy study (n = 191); 230 participants transitioned into an ongoing 7-year study to assess safety and efficacy. RESULTS: The average participant was 34 (±11.4) years old with epilepsy for 19.6 (±11.4) years. The median preimplant frequency of disabling partial or generalized tonic-clonic seizures was 10.2 seizures a month. The median percent seizure reduction in the randomized blinded controlled trial was 44% at 1 year and 53% at 2 years (p \u3c 0.0001, generalized estimating equation) and ranged from 48% to 66% over postimplant years 3 through 6 in the long-term study. Improvements in quality of life were maintained (p \u3c 0.05). The most common serious device-related adverse events over the mean 5.4 years of follow-up were implant site infection (9.0%) involving soft tissue and neurostimulator explantation (4.7%). CONCLUSIONS: The RNS System is the first direct brain responsive neurostimulator. Acute and sustained efficacy and safety were demonstrated in adults with medically refractory partial onset seizures arising from 1 or 2 foci over a mean follow-up of 5.4 years. This experience supports the RNS System as a treatment option for refractory partial seizures. CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that for adults with medically refractory partial onset seizures, responsive direct cortical stimulation reduces seizures and improves quality of life over a mean follow-up of 5.4 years