Energy loss analysis of an integrated space power distribution system

The results of studies related to conceptual topologies of an integrated utility-like space power system are described. The system topologies are comparatively analyzed by considering their transmission energy losses as functions of mainly distribution voltage level and load composition. The analysis is expedited by use of a Distribution System Analysis and Simulation (DSAS) software. This recently developed computer program by the Electric Power Research Institute (EPRI) uses improved load models to solve the power flow within the system. However, present shortcomings of the software with regard to space applications, and incompletely defined characteristics of a space power system make the results applicable to only the fundamental trends of energy losses of the topologies studied. Accountability, such as included, for the effects of the various parameters on the system performance can constitute part of a planning tool for a space power distribution system

Searching dynamic Web pages with semi-structured contents

At present, information systems (IS) in higher education are usually supported by databases (DB) and accessed through a Web interface. So happens with SiFEUP, the IS of the Engineering Faculty of the University of Porto (FEUP). The typical SiFEUP user sees the system as a collection of Web pages and is not aware of the fact that most of them do not exist in the sense of being an actual HTML file stored in a server but corresponds to HTML code generated on the fly by a designated program that accesses the DB and brings the most up-to-date information to the user desktop. Typical search engines do not index dynamically generated Web pages or just do that for those that are specifically mentioned in a static page and do not follow on the links the dynamic page may contain. In this paper we describe the development of a search facility for SiFEUP, how the limitations put to indexing dynamic Web pages were circumvented, and an evaluation of the results obtained. The solution involves using a locally developed crawler, the Oracle Text full text indexer, plus meta-information automatically drawn from the DB or manually added to improve the relevance factor calculation.At present, information systems (IS) in higher education are usually supported by databases (DB) and accessed through a Web interface. So happens with SiFEUP, the IS of the Engineering Faculty of the University of Porto (FEUP). The typical SiFEUP user sees the system as a collection of Web pages and is not aware of the fact that most of them do not exist in the sense of being an actual HTML file stored in a server but corresponds to HTML code generated on the fly by a designated program that accesses the DB and brings the most up-to-date information to the user desktop. Typical search engines do not index dynamically generated Web pages or just do that for those that are specifically mentioned in a static page and do not follow on the links the dynamic page may contain. In this paper we describe the development of a search facility for SiFEUP, how the limitations put to indexing dynamic Web pages were circumvented, and an evaluation of the results obtained. The solution involves using a locally developed crawler, the Oracle Text full text indexer, plus meta-information automatically drawn from the DB or manually added to improve the relevance factor calculation

SiFEUP

The information system of the Faculdade de Engenharia da Universidade do Porto is an integrated administrative IS, covering aspects ranging from the school infrastructures and the academic records, to the course plans, scientific productivity or the external assessment processes. It has been built in-house, since 1996, and it has enabled the progressive modernization of many processes and services providing more accurate decision support.This report presents the main aspects of the system organized according to the rules for submission to the EUNIS Elite Award

Photodynamic therapy offers a novel approach to managing miltefosine-resistant cutaneous leishmaniasis

Funding: Engineering and Physical Sciences Research Council of the UK (grants EP/R035164/1 and EP/L015110/1) and the Scottish Funding Council (ODA GCRF fund grant SFC/AN/12/2017).Cutaneous leishmaniasis (CL) is a neglected disease caused by Leishmania parasites. The oral drug miltefosine is effective, but there is a growing problem of drug resistance, which has led to increasing treatment failure rates and relapse of infections. Photodynamic therapy (PDT) combines a light source and a photoactive drug to promote cell death by oxidative stress. Although PDT is effective against several pathogens, its use against drug resistant Leishmania parasites remains unexplored. Herein, we investigated the potential of organic light-emitting diodes (OLEDs) as wearable light sources, which would enable at-home use or ambulatory treatment of CL. We also assessed its impact on combating miltefosine resistance in Leishmania amazonensis-induced CL in mice. Thein vitro activity of OLEDs combined with 1,9-dimethyl-methylene blue (DMMB) (OLED-PDT) was evaluated against wild-type and miltefosine-resistant L. amazonensis strains in promastigote (EC50 = 0.034 μM for both strains) and amastigote forms (EC50 = 0.052 μM and 0.077 μM, respectively). Cytotoxicity in macrophages and fibroblasts was also evaluated. In vivo, we investigated the potential of OLED-PDT in combination with miltefosine using different protocols. Our results demonstrate that OLED-PDT is effective in killing both strains of L. amazonensis by increasing reactive oxygen species and stimulating nitric oxide production. Moreover, OLED-PDT showed great antileishmanial activity in vivo, allowing the reduction of miltefosine dose by half in infected mice using a light dose of 7.8 J/cm2 and 1.5 μM DMMB concentration. In conclusion, OLED-PDT emerges as a new avenue for at-home care and allows a combination therapy to overcome drug resistance in cutaneous leishmaniasis.Peer reviewe

A viewpoint on the use of microalgae as an alternative feedstuff in the context of pig and poultry feeding - a special emphasis on tropical regions

With the current increase in meat and animal products consumption, there is a need to make production systems more sustainable. The use of microalgae in monogastric feeds, replacing widely used conventional feedstuffs such corn and soybean, can be a solution to overcome this problem. Several studies have shown promising results in the use of microalgae in feeding of both pigs and poultry. However, there are several important constraints associated to the production of microalgae. Such constraints are particularly limiting in the context of tropical regions. Research and scientific development on microalgae production systems are thus essential so that may be widely used in monogastric feeding. Herein, we conduct an overview of the major findings in the use of microalgae in the context of monogastric feeding and analyse the major constraints associated to its production and use, particularly in the specific context of tropical regions.info:eu-repo/semantics/submittedVersio

Label-free quantum dot conjugates for human protein IL-2 based on molecularly imprinted polymer

The authors acknowledge the financial support from European Research Council though the Starting Grant, ERC-StG-3P´s/2012, GA 311086, (to MGF Sales) and from the CANCER project (NORTE-01-0145- FEDER-000029).info:eu-repo/semantics/publishedVersio

Advancing the Provision of Pain Education and Learning (APPEAL) study

Objectives Unrelieved pain is a substantial public health concern necessitating improvements in medical education. The Advancing the Provision of Pain Education and Learning (APPEAL) study aimed to determine current levels and methods of undergraduate pain medicine education in Europe. Design and methods Using a cross-sectional design, publicly available curriculum information was sought from all medical schools in 15 representative European countries in 2012–2013. Descriptive analyses were performed on: the provision of pain teaching in dedicated pain modules, other modules or within the broader curriculum; whether pain teaching was compulsory or elective; the number of hours/credits spent teaching pain; pain topics; and teaching and assessment methods. Results Curriculum elements were publicly available from 242 of 249 identified schools (97%). In 55% (133/242) of schools, pain was taught only within compulsory non-pain-specific modules. The next most common approaches were for pain teaching to be provided wholly or in part via a dedicated pain module (74/242; 31%) or via a vertical or integrated approach to teaching through the broader curriculum, rather than within any specific module (17/242; 7%). The curricula of 17/242 schools (7%) showed no evidence of any pain teaching. Dedicated pain modules were most common in France (27/31 schools; 87%). Excluding France, only 22% (47/211 schools) provided a dedicated pain module and in only 9% (18/211) was this compulsory. Overall, the median number of hours spent teaching pain was 12.0 (range 4–56.0 h; IQR: 12.0) for compulsory dedicated pain modules and 9.0 (range 1.0–60.0 h; IQR: 10.5) for other compulsory (non-pain specific) modules. Pain medicine was principally taught in classrooms and assessed by conventional examinations. There was substantial international variation throughout. Conclusions Documented pain teaching in many European medical schools falls far short of what might be expected given the prevalence and public health burden of pain