Psychosocial factors related to children’s active school travel : A comparison of two European regions

Peer reviewedPublisher PD

A stable quasi-periodic 4.18 d oscillation and mysterious occultations in the 2011 MOST light curve of TWHya

We present an analysis of the 2011 photometric observations of TW Hya by the MOST satellite; this is the fourth continuous series of this type. The large-scale light variations are dominated by a strong, quasi-periodic 4.18 d oscillation with superimposed, apparently chaotic flaring activity; the former is most likely produced by stellar rotation with one large hot spot created by a stable accretion funnel in the stable regime of accretion while the latter may be produced by small hot spots, created at moderate latitudes by unstable accretion tongues. A new, previously unnoticed feature is a series of semi-periodic, well defined brightness dips of unknown nature of which 19 were observed during 43 days of our nearly-continuous observations. Re-analysis of the 2009 MOST light curve revealed the presence of 3 similar dips. On the basis of recent theoretical results, we tentatively conclude that the dips may represent occultations of the small hot spots created by unstable accretion tongues by hypothetical optically thick clumps.Comment: Printed in MNRA

A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria

Parasitized red blood cells (RBCs) from children suffering from severe malaria often adhere to complement receptor 1 (CR1) on uninfected RBCs to form clumps of cells known as "rosettes." Despite a well documented association between rosetting and severe malaria, it is controversial whether rosetting is a cause or a correlate of parasite virulence. CR1-deficient RBC show greatly reduced rosetting; therefore, we hypothesized that, if rosetting is a direct cause of malaria pathology, CR1-deficient individuals should be protected against severe disease. In this study, we show that RBC CR1 deficiency occurs in up to 80% of healthy individuals from the malaria-endemic regions of Papua New Guinea. This RBC CR1 deficiency is associated with polymorphisms in the CR1 gene and, unexpectedly, with alpha-thalassemia, a common genetic disorder in Melanesian populations. Analysis of a case-control study demonstrated that the CR1 polymorphisms and alpha-thalassemia independently confer protection against severe malaria. We have therefore identified CR1 as a new malaria resistance gene and provided compelling evidence that rosetting is an important parasite virulence phenotype that should be a target for drug and vaccine development

A search for transits of GJ 581\lowercase{e} and characterization of the host star variability using MOST space telescope photometry

The GJ 581 system has been amply studied since its discovery in 2005: the number of known planets in the system has increased and their orbital parameters are among the most precisely determined for radial velocity detected exoplanets. We have acquired MOST space-based photometry during 2007 and 2009, with the aims of measuring the stellar variability and searching for transits of GJ 581e, respectively. We quantify our sensitivity to shallow transit signals using Monte Carlo simulations, and perform a transit search within the 3$\sigma$ transit windows corresponding to both the circular and Keplerian orbit ephemerides. Our analysis rules out transits for a planet with an orbital period of 3.15 days (GJ 581 e) having a radius larger than 1.62 $R_{\oplus}$ (or a density lower than 2.39 g cm$^{-3}$ for an orbital inclination of 90$^{\circ}$) to 2$\sigma$ confidence. Thus, if the planet transits, we can exclude hydrogen, helium and water theoretical model compositions. The MOST photometry also allows us to rule out transits of GJ 581b within the Keplerian orbit-derived transit window for impact parameter values smaller than $\sim$0.4 and confirm previous results which exclude transits for this planet within the circular orbit-derived transit window, for all plausible interior compositions. We find that the stellar brightness of GJ 581 is stable to within 1%, a characteristic which is favourable to the development of life in the habitable zone of the system. In the 2009 photometry, we detect a stellar signal with a period of 5.586 $\pm$ 0.051 days, which is close to the orbital period of GJ 581b ($P=$5.37 days). However, further monitoring of the system is necessary to verify the nature of this variation.Comment: 11 pages, 2 tables, 10 figures; accepted for publication in Ap

Searching for Trojan Asteroids in the HD 209458 System: Space-based MOST Photometry and Dynamical Modeling

We have searched Microvariability and Oscillations of STars (MOST) satellite photometry obtained in 2004, 2005, and 2007 of the solar-type star HD 209458 for Trojan asteroid swarms dynamically coupled with the system's transiting "hot Jupiter" HD 209458b. Observations of the presence and nature of asteroids around other stars would provide unique constraints on migration models of exoplanetary systems. Our results set an upper limit on the optical depth of Trojans in the HD 209458 system that can be used to guide current and future searches of similar systems by upcoming missions. Using cross-correlation methods with artificial signals implanted in the data, we find that our detection limit corresponds to a relative Trojan transit depth of 1\times10-4, equivalent to ~1 lunar mass of asteroids, assuming power-law Trojan size distributions similar to Jupiter's Trojans in our solar system. We confirm with dynamical interpretations that some asteroids could have migrated inward with the planet to its current orbit at 0.045 AU, and that the Yarkovsky effect is ineffective at eliminating objects of > 1 m in size. However, using numerical models of collisional evolution we find that, due to high relative speeds in this confined Trojan environment, collisions destroy the vast majority of the asteroids in <10 Myr. Our modeling indicates that the best candidates to search for exoTrojan swarms in 1:1 mean resonance orbits with "hot Jupiters" are young systems (ages of about 1 Myr or less). Years of Kepler satellite monitoring of such a system could detect an asteroid swarm with a predicted transit depth of 3\times10-7.Comment: 32 pages, 8 figure

Stable and unstable accretion in the classical T Tauri stars IM Lup and RU Lup as observed by MOST

Results of the time variability monitoring of the two classical T Tauri stars, RU Lup and IM Lup, are presented. Three photometric data sets were utilised: (1) simultaneous (same field) MOST satellite observations over four weeks in each of the years 2012 and 2013, (2) multicolour observations at the SAAO in April - May of 2013, (3) archival V-filter ASAS data for nine seasons, 2001 - 2009. They were augmented by an analysis of high-resolution, public-domain VLT-UT2 UVES spectra from the years 2000 to 2012. From the MOST observations, we infer that irregular light variations of RU Lup are caused by stochastic variability of hot spots induced by unstable accretion. In contrast, the MOST light curves of IM Lup are fairly regular and modulated with a period of about 7.19 - 7.58 d, which is in accord with ASAS observations showing a well defined 7.247+/-0.026 d periodicity. We propose that this is the rotational period of IM Lup and is due to the changing visibility of two antipodal hot spots created near the stellar magnetic poles during the stable process of accretion. Re-analysis of RU Lup high-resolution spectra with the Broadening Function approach reveals signs of a large polar cold spot, which is fairly stable over 13 years. As the star rotates, the spot-induced depression of intensity in the Broadening Function profiles changes cyclically with period 3.71058 d, which was previously found by the spectral cross-correlation method.Comment: 14 pages, 7 figures. Accepted by MNRA

Identification of Epstein-Barr virus replication proteins in Burkitt’s lymphoma cells

The working model to describe the mechanisms used to replicate the cancer-associated virus Epstein-Barr virus (EBV) is partly derived from comparisons with other members of the Herpes virus family. Many genes within the EBV genome are homologous across the herpes virus family. Published transcriptome data for the EBV genome during its lytic replication cycle show extensive transcription, but the identification of the proteins is limited. We have taken a global proteomics approach to identify viral proteins that are expressed during the EBV lytic replication cycle. We combined an enrichment method to isolate cells undergoing EBV lytic replication with SILAC-labeling coupled to mass-spectrometry and identified viral and host proteins expressed during the OPEN ACCESS Pathogens 2015, 4 740 EBV lytic replication cycle. Amongst the most frequently identified viral proteins are two components of the DNA replication machinery, the single strand DNA binding protein BALF2, DNA polymerase accessory protein BMRF1 and both subunits of the viral ribonucleoside-diphosphate reductase enzyme (BORF2 and BaRF1). An additional 42 EBV lytic cycle proteins were also detected. This provides proteomic identification for many EBV lytic replication cycle proteins and also identifies post-translational modifications

Using MOST to reveal the secrets of the mischievous Wolf-Rayet binary CV Ser

The WR binary CV Serpentis (= WR113, WC8d + O8-9IV) has been a source of mystery since it was shown that its atmospheric eclipses change with time over decades, in addition to its sporadic dust production. The first high-precision time-dependent photometric observations obtained with the MOST space telescope in 2009 show two consecutive eclipses over the 29d orbit, with varying depths. A subsequent MOST run in 2010 showed a seemingly asymmetric eclipse profile. In order to help make sense of these observations, parallel optical spectroscopy was obtained from the Mont Megantic Observatory (2009, 2010) and from the Dominion Astrophysical Observatory (2009). Assuming these depth variations are entirely due to electron scattering in a beta-law wind, an unprecedented 62% increase in mass-loss rate is observed over one orbital period. Alternatively, no change in mass-loss rate would be required if a relatively small fraction of the carbon ions in the wind globally recombined and coaggulated to form carbon dust grains. However, it remains a mystery as to how this could occur. There also seems to be evidence for the presence of corotating interaction regions (CIR) in the WR wind: a CIR-like signature is found in the light curves, implying a potential rotation period for the WR star of 1.6 d. Finally, a new circular orbit is derived, along with constraints for the wind collision.Comment: 11 pages, 11 figures, 5 table

Transit Timing Observations from Kepler: VI. Potentially interesting candidate systems from Fourier-based statistical tests

We analyze the deviations of transit times from a linear ephemeris for the Kepler Objects of Interest (KOI) through Quarter six (Q6) of science data. We conduct two statistical tests for all KOIs and a related statistical test for all pairs of KOIs in multi-transiting systems. These tests identify several systems which show potentially interesting transit timing variations (TTVs). Strong TTV systems have been valuable for the confirmation of planets and their mass measurements. Many of the systems identified in this study should prove fruitful for detailed TTV studies.Comment: 32 pages, 6 of text and one long table, Accepted to Ap