Analysis of X.500 Distributed Directory Refresh Strategies

Distributed database directory refresh strategies, commonly recommended for the X.500 standard, are defined and analytically modeled for variations on push/pull and total/differential under idealistic asynchronous control conditions. The models are implemented in a HyperCard-based tool called DirMod (for "directory model"). Experimental test results show important elapsed time performance tradeoff among the different strategies, and live test data contribute to the verification of the models.http://deepblue.lib.umich.edu/bitstream/2027.42/107872/1/citi-tr-90-6.pd

A new revolutionary practice: operaisti and the 'refusal of work' in 1970's Italy

The social protest that engulfed Italy in the 1970s found a theoretical analysis in the work of the operaisti. Through a series of concepts, they outlined a new revolutionary practice that aimed to return to a more authentic reading of Marxism. This article focuses on the notion of ‘refusal of work’ and the ancillary concept of ‘appropriation’ and examines how these theoretical tools emerged out of radical protest in factories and were put forward by the operaisti as a central plank of a revolutionary strategy for the working clas

Phased diploid genome assembly with single-molecule real-time sequencing

While genome assembly projects have been successful in many haploid and inbred species, the assembly of noninbred or rearranged heterozygous genomes remains a major challenge. To address this challenge, we introduce the open-source FALCON and FALCON-Unzip algorithms (https://github.com/PacificBiosciences/FALCON/) to assemble long-read sequencing data into highly accurate, contiguous, and correctly phased diploid genomes. We generate new reference sequences for heterozygous samples including an F1 hybrid of Arabidopsis thaliana, the widely cultivated Vitis vinifera cv. Cabernet Sauvignon, and the coral fungus Clavicorona pyxidata, samples that have challenged short-read assembly approaches. The FALCON-based assemblies are substantially more contiguous and complete than alternate short- or long-read approaches. The phased diploid assembly enabled the study of haplotype structure and heterozygosities between homologous chromosomes, including the identification of widespread heterozygous structural variation within coding sequences

Analysis of X.500 Distributed Directory Refresh Strategies

Distributed database directory refresh strategies, commonly recommended for the X.500 standard, are defined and analytically modeled for variations on push/pull and total/differential under idealistic asynchronous control conditions. The models are implemented in a HyperCard-based tool called DirMod (for "directory model"). Experimental test results show important elapsed time performance tradeoff among the different strategies, and live test data contribute to the verification of the models. 1. Introduction Overview In distributed systems, one major concern is the mapping of names to services. A directory provides this mechanism. The problem of replicating directory information and maintaining the data (updating...) is still being addressed. We choose to study the emerging X.500 standard for directories since Quipu (an implementation of X.500) is readily available [Kille89, KRRT90], and this would be ideal for experimentation to discover the good, the bad and the ugly about directorie..

Divergent phosphorylation pattern of tau in P301L tau transgenic mice

Aggregates of hyperphosphorylated tau are prominent in brains of patients with Alzheimer's disease or frontotemporal dementia (FTD). They have been reproduced in animal models following the identification of tau mutations in familial cases of FTD. This includes our previously generated transgenic model, pR5, which expresses FTD (P301L) mutant tau in neurons. The mice are characterized by tau aggregation including tangle (NFT) formation, memory impairment and mitochondrial dysfunction. In 8-month- old mice, S422 phosphorylation of tau is linked to NFT formation, however, a detailed analysis of tau solubility, phosphorylation and aggregation has not been done nor have the mice been monitored until a high age. Here, we undertook an analysis by immunohistochemistry, Gallyas impregnation and Western blotting of brains from 3 month- up to 20 month-old mice. NFTs first appeared at 6 months in the amygdala, followed by the CA1 region of the hippocampus. As the mice get older, the solubility of tau is decreased as determined by sequential extractions. Histological analysis revealed increased phosphorylation at the AT180, AT270 and 12E8 epitopes with ageing. The numbers of AT8-positive neurons increased from 3 to 6 months old. However, whereas S422 appeared only late and concomitantly with NFT formation, the only neurons left with AT8-reactivity at 20 months were those that had undergone NFT formation. As hyperphosphorylated tau continued to accumulate, the lack of AT8-reactivity suggests regulatory mechanisms in specifically dephosphorylating the AT8 epitope in the remaining neurons. Thus, differential regulation of phosphorylation is important for NFT formation in neurodegenerative diseases with tau pathology

Routledge International Handbook of Memory Studies

The field of Memory Studies continually refocuses and reinvents itself, searching for moments, events, and places in an effort to locate the multitude of ways that memory makes it way into lives, or in fact is life (see Del Giudice et al; Ventura; McCraty). At times overtly political and public, at other times, subtle and ephemeral, Memory Studies since the 1980s has gained an increasing amount of attention from scholars in widely varying disciplines and perspectives (Mendels 2007; Radstone and Schwartz 2010; Olick et al. 2011; Kattago 2015). As a consequence of this creative and intensive development, Memory Studies now represents a well-established field of research (Tulving and Craik 2005; Erll and Nunning 2010). However, this creative variety of perspectives has implied, to some extent, a theoretical isolationism, most often underpinned by disciplinary conventions. Even though Memory Studies has been investigated from different disciplinary homes (Rubin 1996; Climo and Cattell 2002; Dunlosky and Bjork 2008), there is often little exchange or collaboration between the different perspectives. Therefore, it is regularly the case that, for example, well-known phenomena in the field of neurophysiology are still ignored by social scientists working on the same topic and vice versa. Such theoretical isolationism within the field also derives from the variety of national contexts in which Memory Studies has emerged. Approaches to Memory Studies vary from country to country both in regards to their historical development, empirical focus and conceptual framework (Van Dyke and Alcock 2003; see Olick; Hutton; Inglis). In this respect the Handbook attempts to explore the dynamic tension between, for example, national memories, diasporas, and migrations while pointing toward research in transnational memory production (see Güran-Aydin with DeNora; Hagen). The implied idea is that the analytical framework that has emerged in different nations for the study of memories derives and is shaped by pasts in that particular nation. These memories are ultimately elaborated and inscribed in the national public discourse and drive the “methodological nationalism” present in much empirical work on memory (de Cesari and Ann Rigney 2014)