The Earth as an extrasolar transiting planet - II: HARPS and UVES detection of water vapor, biogenic O2_2, and O3_3

The atmospheric composition of transiting exoplanets can be characterized during transit by spectroscopy. For the transit of an Earth twin, models predict that biogenic $O_2$ and $O_3$ should be detectable, as well as water vapour, a molecule linked to habitability as we know it on Earth. The aim is to measure the Earth radius versus wavelength $\lambda$ - or the atmosphere thickness $h(\lambda)$ - at the highest spectral resolution available to fully characterize the signature of Earth seen as a transiting exoplanet. We present observations of the Moon eclipse of 21-12-2010. Seen from the Moon, the Earth eclipses the Sun and opens access to the Earth atmosphere transmission spectrum. We used HARPS and UVES spectrographs to take penumbra and umbra high-resolution spectra from 3100 to 10400 Ang. A change of the quantity of water vapour above the telescope compromised the quality of the UVES data. We corrected for this effect in the data processing. We analyzed the data by 3 different methods. The 1st method is based on the analysis of pairs of penumbra spectra. The 2nd makes use of a single penumbra spectrum, and the 3rd of all penumbra and umbra spectra. Profiles $h(\lambda)$ are obtained with the three methods for both instruments. The 1st method gives the best result, in agreement with a model. The second method seems to be more sensitive to the Doppler shift of solar spectral lines with respect to the telluric lines. The 3rd method makes use of umbra spectra which bias the result, but it can be corrected for this a posteriori from results with the first method. The 3 methods clearly show the spectral signature of the Rayleigh scattering in the Earth atmosphere and the bands of H$_2$O, O$_2$, and O$_3$. Sodium is detected. Assuming no atmospheric perturbations, we show that the E-ELT is theoretically able to detect the $O_2$ A-band in 8~h of integration for an Earth twin at 10pc.Comment: Final version accepted for publication in A&A - 21 pages, 27 figures. Abstract above slightly shortened wrt the original. The ArXiv version has low resolution figures, but a version with full resolution figures is available here: http://www.obs-hp.fr/~larnold/publi_to_download/eclipse2010_AA_v5_final.pd

Editorial: Anthropogenic wildlife movements and infectious diseases: Health and conservation perspectives

EditorialS

The bovine QTL viewer: a web accessible database of bovine Quantitative Trait Loci

BACKGROUND: Many important agricultural traits such as weight gain, milk fat content and intramuscular fat (marbling) in cattle are quantitative traits. Most of the information on these traits has not previously been integrated into a genomic context. Without such integration application of these data to agricultural enterprises will remain slow and inefficient. Our goal was to populate a genomic database with data mined from the bovine quantitative trait literature and to make these data available in a genomic context to researchers via a user friendly query interface. DESCRIPTION: The QTL (Quantitative Trait Locus) data and related information for bovine QTL are gathered from published work and from existing databases. An integrated database schema was designed and the database (MySQL) populated with the gathered data. The bovine QTL Viewer was developed for the integration of QTL data available for cattle. The tool consists of an integrated database of bovine QTL and the QTL viewer to display QTL and their chromosomal position. CONCLUSION: We present a web accessible, integrated database of bovine (dairy and beef cattle) QTL for use by animal geneticists. The viewer and database are of general applicability to any livestock species for which there are public QTL data. The viewer can be accessed at

A brief introduction to mixed effects modelling and multi-model inference in ecology

Acknowledgements This paper is the result of a University of Exeter workshop on best practice for the application of mixed effects models and model selection in ecological studies Funding Xavier A. Harrison was funded by an Institute of Zoology Research Fellowship. David Fisher was funded by NERC studentship NE/H02249X/1. Lynda Donaldson was funded by NERC studentship NE/L501669/1. Beth S. Robinson was funded by the University of Exeter and the Animal and Plant Health Agency as part of ‘Wildlife Research Co-Operative’. Maria Correa-Cano was funded by CONACYT (The Mexican National Council for Science and Technology) and SEP (The Mexican Ministry of Education). Cecily Goodwin was funded by the Forestry Commission and NERC studentship NE/L501669/1. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Overexpression of Map3k7 activates sinoatrial node-like differentiation in mouse ES-derived cardiomyocytes

In vivo, cardiomyocytes comprise a heterogeneous population of contractile cells defined by unique electrophysiologies, molecular markers and morphologies. The mechanisms directing myocardial cells to specific sub-lineages remain poorly understood. Here we report that overexpression of TGFβ-Activated Kinase (TAK1/Map3k7) in mouse embryonic stem (ES) cells faithfully directs myocardial differentiation of embryoid body (EB)-derived cardiac cells toward the sinoatrial node (SAN) lineage. Most cardiac cells in Map3k7-overexpressing EBs adopt markers, cellular morphologies, and electrophysiological behaviors characteristic of the SAN. These data, in addition to the fact that Map3k7 is upregulated in the sinus venous—the source of cells for the SAN—suggest that Map3k7 may be an endogenous regulator of the SAN fate

Projected distributions of Southern Ocean albatrosses, petrels and fisheries as a consequence of climatic change

Given the major ongoing influence of environmental change on the oceans, there is a need to understand and predict the future distributions of marine species in order to plan appropriate mitigation to conserve vulnerable species and ecosystems. In this study we use tracking data from seven large seabird species of the Southern Ocean (black‐browed albatross Thalassarche melanophris, grey‐headed albatross T. chrysostoma, northern giant petrel Macronectes halli, southern giant petrel M. giganteus, Tristan albatross Diomedea dabbenena, wandering albatross D. exulans and white‐chinned petrel Procellaria aequinoctialis, and on fishing effort in two types of fisheries (characterised by low or high‐bycatch rates), to model the associations with environmental variables (bathymetry, chlorophyll‐a concentration, sea surface temperature and wind speed) through ensemble species distribution models. We then projected these distributions according to four climate change scenarios built by the Intergovernmental Panel for Climate Change for 2050 and 2100. The resulting projections were consistent across scenarios, indicating that there is a strong likelihood of poleward shifts in distribution of seabirds, and several range contractions (resulting from a shift in the northern, but no change in the southern limit of the range in four species). Current trends for southerly shifts in fisheries distributions are also set to continue under these climate change scenarios at least until 2100; some of these may reflect habitat loss for target species that are already over‐fished. It is of particular concern that a shift in the distribution of several highly threatened seabird species would increase their overlap with fisheries where there is a high‐bycatch risk. Under such scenarios, the associated shifts in distribution of seabirds and increases in bycatch risk will require much‐improved fisheries management in these sensitive areas to minimise impacts on populations in decline

Body composition and physical activity as mediators in the relationship between socioeconomic status and blood pressure in young South African women: a structural equation model analysis.

OBJECTIVES: Varying hypertension prevalence across different socioeconomic strata within a population has been well reported. However, the causal factors and pathways across different settings are less clear, especially in sub-Saharan Africa. Therefore, this study aimed to compare blood pressure (BP) levels and investigate the extent to which socioeconomic status (SES) is associated with BP, in rural and urban South Africa women. SETTING: Rural and urban South Africa. DESIGN: Cross-sectional. PARTICIPANTS: Cross-sectional data on SES, total moderate and vigorous physical activity (MVPA), anthropometric and BP were collected on rural (n=509) and urban (n=510) young black women (18-23 years age). Pregnant and mentally or physically disabled women were excluded from the study. RESULTS: The prevalence of combined overweight and obesity (46.5% vs 38.8%) and elevated BP (27.0% vs 9.3%) was higher in urban than rural women, respectively. Results from the structural equation modelling showed significant direct positive effects of body mass index (BMI) on systolic BP (SBP) in rural, urban and pooled datasets. Negative direct effects of SES on SBP and positive total effects of SES on SBP were observed in the rural and pooled datasets, respectively. In rural young women, SES had direct positive effects on BMI and was negatively associated with MVPA in urban and pooled analyses. BMI mediated the positive total effects association between SES and SBP in pooled analyses (ß 0.46; 95% CI 0.15 to 0.76). CONCLUSIONS: Though South Africa is undergoing nutritional and epidemiological transitions, the prevalence of elevated BP still varies between rural and urban young women. The association between SES and SBP varies considerably in economically diverse populations with BMI being the most significant mediator. There is a need to tailor prevention strategies to take into account optimising BMI when designing strategies to reduce future risk of hypertension in young women.SAN is supported by the UK MRC DfID African Research Leader Scheme and by the DST-NRF Centre of Excellence in Human Development at the University of the Witwatersrand, Johannesburg. Birth to Twenty data collection was supported by the Wellcome Trust under grant (092097/Z/10/Z). The MRC/Wits- Agincourt Unit is supported by the South African Medical Research Council, and the Wellcome Trust under grants (058893/Z/99/A, 069683/Z/02/Z, 085477/Z/08/Z, 085477/B/08/Z)

Prostanoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Prostanoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Prostanoid Receptors [644]) are activated by the endogenous ligands prostaglandins PGD2, PGE1, PGE2 , PGF2α, PGH2, prostacyclin [PGI2] and thromboxane A2. Measurement of the potency of PGI2 and thromboxane A2 is hampered by their instability in physiological salt solution; they are often replaced by cicaprost and U46619, respectively, in receptor characterization studies

U-Pb dating and geochemical dataset of fracture-filling calcite veins from the Bóixols-Sant Corneli anticline (Southern Pyrenees)

U-Pb dating and geochemical analyzes (δ18O, δ13C, Δ47, 87Sr/86Sr and elemental composition) have been applied to fracture-filling calcite veins and host carbonates from the Bóixols-Sant Corneli anticline, which developed along the front of the Bóixols thrust sheet in the Southern Pyrenees. This robust dataset is used to determine: (i) the absolute timing of fracturing and mineralization from fluid flow; (ii) the age and duration of fold evolution; and (iii) the variations and implications of fluid behavior across the anticline, as has been described in the article “Spatio-temporal variation of fluid flow behavior along a fold: The Bóixols-Sant Corneli anticline (Southern Pyrenees) from U–Pb dating and structural, petrographic, and geochemical constraints – Marine and Petroleum Geology (2022) (Muñoz-López et al., 2022). In this new contribution, we present the raw data that have been analyzed and discussed in the related research article and, also, the whole elemental and REE composition of calcite veins and host carbonates that has not been published yet. These data may be used to unravel the age and origin of veins, to understand their sequential evolution in orogenic belts and to compare our results with those obtained in similar settings worldwide.</p