Low-Level Prenatal and Postnatal Blood Lead Exposure and Adrenocortical Responses to Acute Stress in Children

BACKGROUND: A few recent studies have demonstrated heightened hypothalamic–pituitary–adrenal (HPA) axis reactivity to acute stress in animals exposed to heavy metal contaminants, particularly lead. However, Pb-induced dysregulation of the HPA axis has not yet been studied in humans. OBJECTIVE: In this study, we examined children’s cortisol response to acute stress (the glucocorticoid product of HPA activation) in relation to low-level prenatal and postnatal Pb exposure. METHODS: Children’s prenatal blood Pb levels were determined from cord blood specimens, and postnatal lead levels were abstracted from pediatrician and state records. Children’s adrenocortical responses to an acute stressor were measured using assays of salivary cortisol before and after administration of a standard cold pressor task. RESULTS: Pb exposure was not associated with initial salivary cortisol levels. After an acute stressor, however, increasing prenatal and postnatal blood Pb levels were independently associated with significantly heightened salivary cortisol responses. CONCLUSIONS: Our results suggest that relatively low prenatal and postnatal blood lead levels— notably those below the 10 µg/dL blood lead level identified by the Centers for Disease Control and Prevention for public health purposes—can alter children’s adrenocortical responses to acute stress. The behavioral and health consequences of this Pb-induced HPA dysregulation in children have yet to be determined

The decline and conservation of bumblebees

Declines in bumblebee species in the last 60 years are well documented in Europe, where they are primarily driven by habitat loss and declines in floral abundance and diversity resulting from agricultural intensification. Impacts of habitat degradation and fragmentation are likely to be compounded by the social nature of bumblebees and their largely monogamous breeding system which renders their effective population size low. Hence populations are susceptible to stochastic extinction events and inbreeding. In North America, catastrophic declines of some bumblebee species since the 1990s are probably attributable to the accidental introduction of a non-native parasite from Europe, a result of global trade in domesticated bumblebee colonies used for pollination of greenhouse crops. Given the importance of bumblebees as pollinators of crops and wildflowers, it is vital that steps be taken to prevent further declines. Suggested measures include tight regulation of commercial bumblebee use and targeted use of agri-environment schemes to enhance floristic diversity in agricultural landscapes

Local and exotic sources of sarsen debitage at Stonehenge revealed by geochemical provenancing

The application of novel geochemical provenancing techniques has changed our understanding of the construction of Stonehenge, by identifying West Woods on the Marlborough Downs as the likely source area for the majority of the extant sarsen megaliths at the monument. In this study, we apply the same techniques to saccharoid sarsen fragments from three excavations within and outwith the main Sarsen Circle to expand our understanding of the provenance of sarsen debitage present at the monument. Through pXRF analysis, we demonstrate that the surface geochemistry of 1,028 excavated sarsen fragments is significantly affected by subsurface weathering following burial in a way that cannot be overcome by simple cleaning. However, we show that this effect is surficial and does not have a volumetrically significant impact, thus permitting the subsequent use of whole-rock analytical methods. Comparison of ICP-AES and ICP-MS trace element data from 54 representative sarsen fragments with equivalent data from Stone 58 at Stonehenge demonstrates that none are debitage produced during the dressing of this megalith or its 49 chemical equivalents at the monument. Further inspection of the ICP-MS data reveals that 22 of these fragments fall into three distinct geochemical ‘families’. None of these families overlap with the geochemical signature of Stone 58 and its chemical equivalents, implying that sarsen imported from at least a further three locations (in addition to West Woods) is present at Stonehenge. Comparison of immobile trace element signatures from the 54 excavated sarsen fragments against equivalent data for 20 sarsen outcrop areas across southern Britain shows that 15 of the fragments can be linked to specific localities. Eleven of these were likely sourced from Monkton Down, Totterdown Wood and West Woods on the Marlborough Downs (25–33 km north of Stonehenge). Three fragments likely came from Bramdean, Hampshire (51 km southeast of Stonehenge), and one from Stoney Wish, East Sussex (123 km to the southeast). Technological analysis and refitting shows that one of the fragments sourced from Monkton Down was part of a 25.7 cm × 17.9 cm flake removed from the outer surface of a large sarsen boulder, most probably during on-site dressing. This adds a second likely source area for the sarsen megaliths at Stonehenge in addition to West Woods. At this stage, we can only speculate on why sarsen from such diverse sources is present at Stonehenge. We do not know whether the fragments analysed by ICP-MS were removed from (i) the outer surface of Stones 26 or 160 (which are chemically distinct to the other extant sarsen megaliths), (ii) one of the c.28 sarsen megaliths and lintels from the c.60 erected during Stage 2 of the construction of Stonehenge that may now be missing from the monument, or (iii) one of the dismantled and destroyed sarsen megaliths associated with Stage 1 of the monument. With the exception of the fragment sourced from Monkton Down, it is also possible that the analysed fragments were (iv) pieces of saccharoid sarsen hammerstones or their pre-forms, or (v) small blocks brought on-site for ceremonial or non-ceremonial purposes

"Geomorphological record of a former ice stream to ice shelf lateral transition zone in Northeast Greenland

Understanding ice stream dynamics over decadal to millennial timescales is crucial for improving numerical model projections of ice sheet behaviour and future ice loss. In marine-terminating settings, ice shelves play a critical role in controlling ice-stream grounding line stability and ice flux to the ocean, but few studies have investigated the terrestrial lateral geomorphological imprint of ice shelves during deglaciation. Here, we document the terrestrial deglacial landsystem of Nioghalvfjerdsfjorden Glacier (79N) in northeast Greenland, following the Last Glacial Maximum, and the margin's lateral transition to a floating ice shelf. High-elevation areas are influenced by local ice caps and display autochthonous to allochthonous blockfields that mark the interaction of local ice caps with the ice stream below. A thermal transition from cold- to warm-based ice is denoted by the emplacement of erratics onto allochthonous blockfields. Below ~600 m above sea level (a.s.l.) glacially abraded bedrock surfaces and assemblages of lateral moraines, ‘hummocky’ moraine, fluted terrain, and ice-contact deltas record the former presence of warm-based ice and thinning of the grounded ice stream margin through time. In the outer fjord a range of landforms such as ice shelf moraines, dead-ice topography, and weakly developed ice marginal glaciofluvial outwash was produced by an ice shelf during deglaciation. Along the mid- and inner-fjord areas this ice shelf signal is absent, suggesting ice shelf disintegration prior to grounding line retreat under tidewater conditions. However, below the marine limit, the geomorphological record along the fjord indicates the expansion of the 79N ice shelf during the Neoglacial, which culminated in the Little Ice Age. This was followed by 20th century recession, with the development of a suite of compressional ice shelf moraines, ice-marginal fluvioglacial corridors, kame terraces, dead-ice terrain, and crevasse infill ridges. These mark rapid ice shelf thinning and typify the present-day ice shelf landsystem in a warming climate

Holocene history of the 79° N ice shelf reconstructed from epishelf lake and uplifted glaciomarine sediments

Acknowledgements This work was funded by a NERC standard grant (grant no. NE/N011228/1), and some radiocarbon analysis was funded by NEIF (grant NE/S011587/1; allocation number 2169.1118). We thank the Alfred Wegener Institute, particularly Angelika Humbert and Hicham Rafiq, for significant logistic support through the iGRIFF project. Additional support was provided by Station Nord (Jorgen Skafte), Nordlandair, Air Greenland, and the Joint Arctic Command. Naalakkersuisut (government of Greenland) provided scientific survey (VU-00121) and export (046/2017) licences for this work. Finally, we would like to thank our (Nanu Travel) field ranger Isak (and dog Ooni) for keeping us safe in the field and taking great pleasure in beating James A. Smith at cards. Financial support This research has been supported by the Natural Environment Research Council (grant no. NE/N011228/1).Peer reviewedPublisher PD

Principles and Practices of Neurodevelopmental Assessment in Children: Lessons Learned from the Centers for Children’s Environmental Health and Disease Prevention Research

Principles and practices of pediatric neurotoxicology are reviewed here with the purpose of guiding the design and execution of the planned National Children’s Study. The developing human central nervous system is the target organ most vulnerable to environmental chemicals. An investigation of the effects of environmental exposures on child development is a complex endeavor that requires consideration of numerous critical factors pertinent to a study’s concept, design, and execution. These include the timing of neurodevelopmental assessment, matters of biologic plausibility, site, child and population factors, data quality assurance and control, the selection of appropriate domains and measures of neurobehavior, and data safety and monitoring. Here we summarize instruments for the assessment of the neonate, infant, and child that are being employed in the Centers for Children’s Environmental Health and Disease Prevention Research, sponsored by the National Institute of Environmental Health Sciences and the U.S. Environmental Protection Agency, discuss neural and neurobiologic measures of development, and consider the promises of gene–environment studies. The vulnerability of the human central nervous system to environmental chemicals has been well established, but the contribution these exposures may make to problems such as attention deficit disorder, conduct problems, pervasive developmental disorder, or autism spectrum disorder remain uncertain. Large-scale studies such as the National Children’s Study may provide some important clues. The human neurodevelopmental phenotype will be most clearly represented in models that include environmental chemical exposures, the social milieu, and complex human genetic characteristics that we are just beginning to understand

Locating oneself in the past to influence the present: Impacts of Neolithic landscapes on mental health well-being

There are well-established links between mental health and the environment. Mental illness is a global issue, and international policies increasingly focus on promoting mental health well-being through community-based approaches, including non-clinical initiatives such as therapeutic landscapes and the use of heritage assets. However, the empirical evidence-base for the impact of such initiatives is limited. This innovative study, known as Human Henge, used a mixed-methods approach to investigate the impact of immersive experiences of prehistoric landscapes on the well-being of participants with mental health issues. Uniquely, the study followed participants for a year after their participation in the project to explore the long-term impact of their experiences on their mental well-being. Findings highlight that, overall, participants experienced improved mental health well-being from baseline to mid- and end-of programme (p = 0.01 & 0.003), as well as one-year post-programme (p = 0.03). Qualitative data indicated the reconnection of participants with local communities, and with other people, in ways that improved their mental health well-being. These data highlight the effectiveness of using heritage as a means of improving the well-being of people with mental health issues