Expression of p53 in toluidine blue positive oral squamous cell carcinoma lesions and expression of Ki67 in vinegar positive oral squamous cell carcinoma lesions

The aims of this study were to investigate the sensitivity and specificity of toluidine blue and/or vinegar in oral cancer screening and to examine the correlation between clinical screening using toluidine blue and vinegar and the expression of the tumor marker p53 and proliferation marker Ki67, respectively. The study consisted of 87 patients with suspected oral squamous cell carcinoma lesions. Toluidine blue and/or vinegar were applied to the lesions, followed by biopsies. The tissues were diagnosed histopathologically and underwent immunohistochemical process for p53 or Ki67. The results revealed that the sensitivity and specificity of oral cancer screening using toluidine blue were 93% and 46%, respectively; whereas the sensitivity and specificity using vinegar were 85% and 81%, respectively. A statistically significant correlation between the use of vinegar and the expression of Ki67 (p = 0.019) was observed. Although there was a difference in the expression of p53 between specimens that were positive and negative to toluidine blue, the correlation did not reach a significant level. Based on the results from this study, vinegar has a lower sensitivity than toluidine blue but a higher specificity for oral cancer screening. The results of the clinical screening using vinegar correlated with the expression of Ki67 at the cellular level

Deoxygenation of benzaldehyde over CsNaX zeolites

The deoxygenation of benzaldehyde to benzene and toluene was investigated on basic CsNaX, and NaX zeolite catalysts. It was observed that as-prepared CsNaX, containing Cs in excess, displays high activity for direct decarbonylation of benzaldehyde to benzene. However, in parallel with the decarbonylation reaction, condensation of surface products occurs. Therefore, the lower pore volume of catalyst having excess Cs leads to lower catalyst stability. Decomposition of surface condensation products results in further evolution of benzene and toluene. It is observed that gas-phase H2 can play an important role by reducing the residence time of surface intermediates, thus decreasing the amount of condensation products that accumulate and lead to catalyst deactivation. Hydrogen transfer to the condensation surface products accelerates the decomposition of these condensation compounds primarily into toluene. NaX catalyst and washed CsNaX do not exhibit a high initial activity for direct decarbonylation, but rather operate via formation of surface condensation products which subsequently decompose yielding benzene and toluene. The residual acidity present in NaX catalysts causes a faster deactivation for this catalyst than for those containing Cs.Fil: Peralta, María Ariela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera". Universidad Nacional del Litoral. Instituto de Investigaciones en Catálisis y Petroquímica "Ing. José Miguel Parera"; ArgentinaFil: Sooknoi, Tawan. Oklahoma State University; Estados UnidosFil: Danuthai, Tanate. Oklahoma State University; Estados UnidosFil: Resasco, Daniel E.. Oklahoma State University; Estados Unido