Management philosophies as applied to major NASA programs

A definition of 'management philosophies' is discussed explaining the position of NASA in the planning and control of space programs and technology. The impact of these philosophies on the Apollo and Saturn 1 programs are described along with the need for the Saturn 5 spacecraft and launch site development. Case studies are included and describe unscheduled events where management decisions were necessary to keep programs on track

Reconstructed storm tracks reveal three centuries of changing moisture delivery to North America

Moisture delivery to western North America is closely linked to variability in the westerly storm tracks of midlatitude cyclones, which are, in turn, modified by larger-scale features such as the El Niño–Southern Oscillation system. Instrumental and modeling data suggest that extratropical storm tracks may be intensifying and shifting poleward due to anthropogenic climate change, but it is difficult to separate recent trends from natural variability because of the large amount of decadal and longer variation in storm tracks and their limited instrumental record. We reconstruct cool-season, midlatitude Pacific storm-track position and intensity from 1693 to 1995 CE using existing tree-ring chronologies along with a network of newly developed chronologies from the U.S. Pacific Northwest, where small variations in storm-track position can have a major influence on hydroclimate patterns. Our results show high interannual-to-multidecadal variability in storm-track position and intensity over the past 303 years, with spectral signatures characteristic of tropical and northern Pacific influences. Comparison with reconstructions of precipitation and tropical sea surface temperature confirms the relationship between shifting drought patterns in the Pacific Northwest and storm-track variability through time and demonstrates the long-term influence of El Niño. These results allow us to place recent storm-track changes in the context of decadal and multidecadal fluctuations across the long-term record, showing that recent changes in storm-track intensity likely represent a warming-related increase amplified by natural decadal variability

A study of the effects of micro-gravity on seed germination

This study will identify characteristics of seed germination dependent upon gravity. To accomplish this objective, four different seed types will be germinated in space and then be compared to a control group germinated on Earth. Both the experimental and control groups will be analyzed on the cellular level for the size of cells, structural anomalies, and gravitational effects. The experiment will be conducted in a Get Away Special Canister (GAS Can no. 608) owned by the U.S. Space and Rocket Center and designed for students. The GAS Can will remain in the cargo bay of the Space Shuttle with minimal astronaut interaction

A Laboratory Investigation of Supersonic Clumpy Flows: Experimental Design and Theoretical Analysis

We present a design for high energy density laboratory experiments studying the interaction of hypersonic shocks with a large number of inhomogeneities. These ``clumpy'' flows are relevant to a wide variety of astrophysical environments including the evolution of molecular clouds, outflows from young stars, Planetary Nebulae and Active Galactic Nuclei. The experiment consists of a strong shock (driven by a pulsed power machine or a high intensity laser) impinging on a region of randomly placed plastic rods. We discuss the goals of the specific design and how they are met by specific choices of target components. An adaptive mesh refinement hydrodynamic code is used to analyze the design and establish a predictive baseline for the experiments. The simulations confirm the effectiveness of the design in terms of articulating the differences between shocks propagating through smooth and clumpy environments. In particular, we find significant differences between the shock propagation speeds in a clumpy medium compared to a smooth one with the same average density. The simulation results are of general interest for foams in both inertial confinement fusion and laboratory astrophysics studies. Our results highlight the danger of using average properties of inhomogeneous astrophysical environments when comparing timescales for critical processes such as shock crossing and gravitational collapse times.Comment: 7 pages, 6 figures. Submitted to the Astrophysical Journal. For additional information, including simulation animations and the pdf and ps files of the paper with embedded high-quality images, see http://pas.rochester.edu/~wm

New Directions in Degenerate Dipolar Molecules via Collective Association

We survey results on the creation of heteronuclear Fermi molecules by tuning a degenerate Bose-Fermi mixture into the neighborhood of an association resonance, either photoassociation or Feshbach, as well as the subsequent prospects for Cooper-like pairing between atoms and molecules. In the simplest case of only one molecular state, corresponding to either a Feshbach resonance or one-color photoassociation, the system displays Rabi oscillations and rapid adiabatic passage between a Bose-Fermi mixture of atoms and fermionic molecules. For two-color photoassociation, the system admits stimulated Raman adiabatic passage (STIRAP) from a Bose-Fermi mixture of atoms to stable Fermi molecules, even in the presence of particle-particle interactions. By tailoring the STIRAP sequence it is possible to deliberately convert only a fraction of the initial atoms, leaving a finite fraction of bosons behind to induce atom-molecule Cooper pairing via density fluctuations; unfortunately, this enhancement is insufficient to achieve a superfluid transition with present ultracold technology. We therefore propose the use of an association resonance that converts atoms and diatomic molecules (dimers) into triatomic molecules (trimers), which leads to a crossover from a Bose-Einstein condensate of trimers to atom-dimer Cooper pairs. Because heteronuclear dimers may possess a permanent electric dipole moment, this overall system presents an opportunity to investigate novel microscopic physics.Comment: 10 pages, 5 figures, 77+ references, submitted to Euro. Phys. J. topical issue on "Ultracold Polar Molecules: Formation and Collisions

Persistence of pressure patterns over North America and the North Pacific since AD 1500

Changes in moisture delivery to western North America are largely controlled by interrelated, synoptic-scale atmospheric pressure patterns. Long-term records of upper-atmosphere pressure and related circulation patterns are needed to assess potential drivers of past severe droughts and evaluate how future climate changes may impact hydroclimatic systems. Here we develop a tree-ring-based climate field reconstruction of cool-season 500 hPa geopotential height on a 2° × 2° grid over North America and the North Pacific to AD 1500 and examine the frequency and persistence of preinstrumental atmospheric pressure patterns using Self-Organizing Maps. Our results show extended time periods dominated by a set of persistent upper-air pressure patterns, providing insight into the atmospheric conditions leading to periods of sustained drought and pluvial periods in the preinstrumental past. A striking shift from meridional to zonal flow occurred at the end of the Little Ice Age and was sustained for several decades

Thomson scattering from a shock front

We have obtained a Thomson scattering spectrum in the collective regime by scattering a probe beam from a shock front, in an experiment conducted at the Omega laser at the Laboratory for Laser Energetics. The probe beam was created by frequency converting a beamline at Omega to a 2 ns2ns pulse of 0.263 μm0.263μm light, focused with a dedicated optical focusing system. The diagnostic system included collecting optics, spectrometer, and streak camera, with a scattering angle of 101°. The target included a primary shock tube, a 20-μm20-μm-thick beryllium drive disk, 0.3-μm0.3-μm-thick polyimide windows mounted on a secondary tube, and a gas fill tube. Detected acoustic waves propagated parallel to the target axis. Ten laser beams irradiated the beryllium disk with 0.351 μm0.351μm light at 5×1014 W/cm25×1014W∕cm2 for 1 ns1ns starting at toto, driving a strong shock through argon gas at ρo = 1 mg/ccρo=1mg∕cc. The 200 J200J probe beam fired at t = 19 nst=19ns for 2 ns2ns, and at t = 20.1 nst=20.1ns a 0.3 ns0.3ns signal was detected. We attribute this signal to scattering from the shocked argon, before the density increased above critical due to radiative collapse.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87893/2/10E504_1.pd

Deep learning-based parameter mapping for joint relaxation and diffusion tensor MR Fingerprinting

Magnetic Resonance Fingerprinting (MRF) enables the simultaneous quantification of multiple properties of biological tissues. It relies on a pseudo-random acquisition and the matching of acquired signal evolutions to a precomputed dictionary. However, the dictionary is not scalable to higher-parametric spaces, limiting MRF to the simultaneous mapping of only a small number of parameters (proton density, T1 and T2 in general). Inspired by diffusion-weighted SSFP imaging, we present a proof-of-concept of a novel MRF sequence with embedded diffusion-encoding gradients along all three axes to efficiently encode orientational diffusion and T1 and T2 relaxation. We take advantage of a convolutional neural network (CNN) to reconstruct multiple quantitative maps from this single, highly undersampled acquisition. We bypass expensive dictionary matching by learning the implicit physical relationships between the spatiotemporal MRF data and the T1, T2 and diffusion tensor parameters. The predicted parameter maps and the derived scalar diffusion metrics agree well with state-of-the-art reference protocols. Orientational diffusion information is captured as seen from the estimated primary diffusion directions. In addition to this, the joint acquisition and reconstruction framework proves capable of preserving tissue abnormalities in multiple sclerosis lesions

Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis.

Obesity and extracellular matrix (ECM) density are considered independent risk and prognostic factors for breast cancer. Whether they are functionally linked is uncertain. We investigated the hypothesis that obesity enhances local myofibroblast content in mammary adipose tissue and that these stromal changes increase malignant potential by enhancing interstitial ECM stiffness. Indeed, mammary fat of both diet- and genetically induced mouse models of obesity were enriched for myofibroblasts and stiffness-promoting ECM components. These differences were related to varied adipose stromal cell (ASC) characteristics because ASCs isolated from obese mice contained more myofibroblasts and deposited denser and stiffer ECMs relative to ASCs from lean control mice. Accordingly, decellularized matrices from obese ASCs stimulated mechanosignaling and thereby the malignant potential of breast cancer cells. Finally, the clinical relevance and translational potential of our findings were supported by analysis of patient specimens and the observation that caloric restriction in a mouse model reduces myofibroblast content in mammary fat. Collectively, these findings suggest that obesity-induced interstitial fibrosis promotes breast tumorigenesis by altering mammary ECM mechanics with important potential implications for anticancer therapies

The Non-Trivial Effective Potential of the `Trivial' lambda Phi^4 Theory: A Lattice Test

The strong evidence for the `triviality' of (lambda Phi^4)_4 theory is not incompatible with spontaneous symmetry breaking. Indeed, for a `trivial' theory the effective potential should be given exactly by the classical potential plus the free-field zero-point energy of the shifted field; i.e., by the one-loop effective potential. When this is renormalized in a simple, but nonperturbative way, one finds, self-consistently, that the shifted field does become non-interacting in the continuum limit. For a classically scale-invariant (CSI) lambda Phi^4 theory one finds m_h^2 = 8 pi^2 v^2, predicting a 2.2 TeV Higgs boson. Here we extend our earlier work in three ways: (i) we discuss the analogy with the hard-sphere Bose gas; (ii) we extend the analysis from the CSI case to the general case; and (iii) we propose a test of the predicted shape of the effective potential that could be tested in a lattice simulation.Comment: 22 pages, LaTeX, DE-FG05-92ER40717-