Septoglomus nigrum, a new arbuscular mycorrhizal fungus from France, Germany and Switzerland

A new arbuscular mycorrhizal fungus, Septoglomus nigrum, was found in several agricultural field sites in France, Germany and Switzerland, especially in extensively to intensively managed natural meadows and pastures and in extensively managed cropping systems. The fungus was propagated in trap pots and single species cultures on Lolium perenne, Trifolium pratense, Plantago lanceolata and Hieracium pilosella. It differentiates black spores with triple-layered walls, 95–175× 90–170 μm in diameter, formed singly in soils or rarely in roots. Phylogenetically, it forms a distinct clade close to S. altomontanum and S. africanum, which can morphologically be distinguished from spores of S. nigrum by the characteristics of the spore wall and by the color, size and shape of the subtending hyphae. An identification key is provided that differentiates all species so far described in Septoglomus

Professional Satisfaction Of Nurses Working In Operating Room Of A Hospital School

Objective: to characterize in a sociodemographic way the nursing staff of the surgical center; Check the degree of importance assigned to each component of satisfaction: autonomy, interaction, professional status, task requirements, organizational policies, and pay; verify job satisfaction perceived by nurses. Method: exploratory, descriptive, quantitative study, consisting of 9 nurses working in the operating room. The research project was approved by the CEP/HULW, CAAE Nº 24597513.2.0000.5183. Data were collected through questionnaires and then analyzed using descriptive statistics in SPSS 20. Results: We found that the standby component was considered the most important for job satisfaction and Professional Status least important. Conclusion: nurses have a low level of job satisfaction, impacting the performance of its activities. Descriptors: Job Satisfaction. Perioperative Nursing. Quality of Life

Descrição dos casos hospitalizados pela COVID-19 em profissionais de saúde nas primeiras nove semanas da pandemia, Brasil, 2020

Objective. Describing the COVID-19 hospitalization in health professionals in Brazil. Methods. Serial cases descriptive study; we included the cases with illness between February 21st and April 15th, 2020; registered in Flu Surveillance Information System (SIVEP-Gripe, in Brazilian acronym). Results. From the 184 (1.76%) cases, 110 (59.8%) were female, with a median age of 44 years (min-max: 23-85). Of the 184, 89 (48.4%) are nursing professionals and 50 (27.2%) are doctors. Still, 92 (50.0%) presented comorbidity, with heart disease predominating (n = 37; 40.2%). Of the 112 professionals with a record of evolution, 85 (75.9%) were cured and 27 (24.1%) died, 18 (66.7%) of whom were male. Conclusion. The profile descripted is similar to the population’s in age and comorbidities, but different in relation to sex. The most affected areas were nursing and medicine.Objetivo. Descrever os casos hospitalizados pela COVID-19 em profissionais de saúde no Brasil. Métodos. Estudo descritivo de tipo Série de Casos; foram incluídos aqueles com adoecimento entre 21 de fevereiro e 15 de abril de 2020, registrados no Sistema de Informação de Vigilância da Gripe (SIVEP-Gripe). Resultados. Dos 184 casos, 110 (59,8%) eram do sexo feminino, com mediana de idade de 44 anos (mínima-máxima: 23-85), 89 (48,4%) eram profissionais da enfermagem e 50 (27,2%) médicos. Ainda, 92 (50,0%) apresentavam comorbidade, predominando cardiopatias (n=37; 40,2%). Dos 112 profissionais com registro de evolução, 85 (75,9%) alcançaram cura e 27 (24,1%) foram a óbito, 18 destes do sexo masculino. Conclusão. O perfil dos profissionais de saúde hospitalizados por COVID-19 é semelhante ao da população quanto à idade e comorbidades; porém, diferente quanto ao sexo. As áreas profissionais mais acometidas foram a Enfermagem e a Medicina

SESSÃO MODELOS EXPERIMENTAIS

ANALYSIS OF THE PRESSURE-VOLUME CURVE OF MICE EXPOSED TO EXHAUST GASES FROM THE COMBUSTION OF CASHEW NUT SHELLS. /ANALYSIS OF THE INFLUENCE OF HIGH-INTENSITY INTERVAL TRAINING ON THE MARKERS BLOOD LACTATE AND GLUCOSE IN WISTAR RATS/ [MDE-3) ANALYSIS OF THE LUNG FUNCTION OF MICE EXPOSED TO MP4.0 FROM THE COMBUSTION OF CASHEW NUT SHELLS (CCC). /THE FULLERENE NANOPARTICLE CGO IS CAPABLE OF PROMOTING FUNCTIONAL CHANGES IN THE LUNG OF MICE. /ANTI-INFLAMMATORY ANTINOCICEPTIVE ACTIONS OF ETHANOLIC EXTRACT FROM Hymenaea courbaril L. IN RODENTS. /ANTINOCICEPTIVE ACTIVITY OF GALACTOMANNANS ISOLATED FROM SEEDS OF Caesa/piniapu/cherrima AND Delonix regia. /ANTIOXIDANT ACTIVITY OF CITRONEULA ACETATE IN MICE. /PRO-INFLAMMATORY ACTIVITY OF LECTIN FROM LEGUMINOUS Centrolobium tomentosum. /EDEMATOGENIC AND ANTINOCICEPTIVE ACTIVITIES OF LECTIN ISOLATED FROM THE ALBUMIN FRACTION OF Acacia famesiana. /EVALUATION OF THE ACTION OF POLYSACCHARIDES FROM THE BARK OF Ximenia americana ON GASTRIC ACIDITY. /EVALUATION OF THE EXPRESSION OF LIPOPHENIC ENZYMES IN ADIPOSE TISSUE OF DIABETIC RATS INDUCED BY STREPTOZOTOCIN AND TREATED WITH MELATONIN AND/OR INSULIN. /EVALUATION OF THE PROTEIN EXPRESSION OF THE HYDROGEN-MYOINOSITOL CO-TRANSPORTER (HMIT) IN CENTRAL NERVOUS TISSUE DURING THE COURSE OF EXPERIMENTAL DIABETES. /EVALUATION OF THE EFFECT OF THE ESSENTIAL OIL OF Lippia alba AND ITS MAJOR CONSTITUENTS CITRAL AND LIMONENE IN ISOLATED TRACHEA AND AORTA OF WISTAR RATS. /EVALUATION OF THE POSSIBLE INVOLVEMENT OF NITRIC OXIDE IN THE GASTROPROTECTIVE ACTIVITY OF THE ESSENTIAL OIL OF THE LEAVES OF Croton rhamnifo/ioides PAX AND HOFFMAN {KNIFE BREAKER}. /EVALUATION OF THE THERAPEUTIC POTENTIAL OF CARNAUBA CERIFEROUS POWDER (Copemicia cerífero MART.) IN THE TREATMENT OF DIET-INDUCED HYPERCHOLESTEROLEMIC MICE. /GENETICALLY MODIFIED MICE AS MODELS FOR ALZHEIM'S DISEASE. /KINETICS OF MARKERS OF REDOX IMBALANCE IN SKELETAL MUSCLE OF WISTAR RATS AFTER AN EXHAUSTIVE EXERCISE SESSION. /BODY WEIGHT CONTROL AND HYPOGLYCEMIC EFFECT OF COMPOUNDS ISOLATED FROM CARNAUBA CERIFEROUS POWDER (Copernicia cerifera MART.) IN DIABETIC ANIMALS. /LONGITUDINAL BONE GROWTH AND TOTAL BONE MASS INCREASE IN TRAINED ANIMALS. /MEMORY IMPAIRMENT IN RATS SUBJECTED TO ALZHEIMER'S DISEASE INDUCED BY INTRACEREBRAL INFUSION OF B-AMYLOID-42. /DETERMINATION OF THE PHYTOCHEMICAL PROFILE, TOXICITY AND ANTICONVULSANT ACTIVITY OFAnnona muricata L. LEAVES. /TEMPORARY DYNAMICS OF GLYCOGEN LEVEL LIVER SYSTEM AFTER A SESSION OF MODERATE PHYSICAL EXERCISE IN RATS. /EFFECT OF ESSENTIAL FATTY ACIDS ON THE REPAIR OF SKIN INJURIES. /DEPRESSANT EFFECT OF ETHANOLIC EXTRACT OF RED ALGAE Meristiel/a echinocarpa ON THE CENTRAL NERVOUS SYSTEM. /EFFECT OF 2,2'-AZOBIS (2-AMIDINOPROPANE) ON THE TRACHEAL SMOOTH MUSCLE OF RATS: MODEL FOR STUDYING REDOX IMBALANCE. /EFFECT OF LIMONENE ON THE MYOMETRIUM OF WISTAR RATS. /EFFECT OF ESSENTIAL OIL OF Hyptis crenata ON LOCOMOTOR ACTIVITY, EXPLORATORY AND ANXIETY IN RATS. /EFFECT OF Platymiscium floribundum VOG ON ALVEOLAR BONE LOSS IN A PRECLINICAL TRIAL OF PERIODONTITIS. /EFFECT OF HIGH INTENSITY INTERVAL TRAINING ON PERFORMANCE IN EXERCISE TEST. /HEALING AND ANTINOCICEPTIVE EFFECTS OF Dinoponera quadriceps VENOM ON SKIN ULCERS IN MICE.ANÁLISE DA CURVA PRESSÃO-VOLUME PULMONAR DE CAMUNDONGOS EXPOSTOS AOS GASES DE EXAUSTÃO DA COMBUSTÃO DA CASCA DA CASTANHA DE CAJU. /ANÁLISE DA INFLUÊNCIA DO TREINAMENTO INTERVALADO DE ALTA INTENSIDADE NOS MARCADORES LACTATO E GLICOSE SANGUÍNEOS EM RATOS WISTAR/ [MDE-3) ANÁLISE DA FUNÇÃO PULMONAR DE CAMUNDONGOS EXPOSTOS AO MP4,0 PROVENIENTE DA COMBUSTÃO DA CASCA DE CASTANHA DE CAJU (CCC).  /A NANOPARTÍCULA FULERENO CGO É CAPAZ DE PROMOVER ALTERAÇÕES FUNCIONAIS NO PULMÃO DE CAMUNDONGOS. /ANTl-INFLAMMATORY ANO ANTINOCICEPTIVE ACTIONS OF ETANOLIC EXTRACT FROM Hymenaea courbaril L. IN RODENTS. /ATIVIDADE ANTINOCICEPTIVA DE GALACTOMANANAS ISOLADAS DAS SEMENTES DE Caesa/piniapu/cherrima E Delonix regia. /ATIVIDADE ANTIOXIDANTE DO ACETATO DE CITRONEULA EM CAMUNDONGOS. /ATIVIDADE PRÓ-INFLAMATÓRIA DA LECTINA DE LEGUMINOSA Centrolobium tomentosum.  /ATIVIDADES EDEMATOGÊNICA E ANTINOCICEPTIVA DA LECTINA ISOLADA DA FRAÇÃO ALBUMI NA DE Acacia famesiana. /AVALIAÇÃO DA AÇÃO DOS POLISSACARÍDEOS DA CASCA DE Ximenia americana NA ACIDEZ GÁSTRICA. /AVALIAÇÃO DA EXPRESSÃO DE ENZIMAS LIPOGÊNICAS DO TECIDO ADIPOSO DE RATOS DIABÉTICOS INDUZIDOS POR ESTREPTOZOTOCINA E TRATADOS COM MELATONINA E/OU INSULINA. /AVALIAÇÃO DA EXPRESSÃO PROTEICA DO CO-TRANSPORTADOR HIDROGÊNIO-MIOINOSITOL (HMIT) EM TECIDO NERVOSO CENTRAL DURANTE O CURSO DO DIABETES EXPERIMENTAL. /AVALI AÇÃO DO EFEITO DO ÓLEO ESSENCIAL DE Lippia alba E DE SEUS CONSTITUINTES MARJORITÁRIOS CITRAL E LIMONENO EM TRAQUEIA E AORTA ISOLADAS DE RATOS WISTAR. /AVALIAÇÃO DO POSSÍVEL ENVOLVIMENTO DO ÓXIDO NÍTRICO NA ATIVIDADE GASTROPROTETORA DO ÓLEO ESSENCIAL DAS FOLHAS DO ÓLEO ESSENCIAL DAS FOLHAS DE Croton rhamnifo/ioides PAX E HOFFMAN {QUEBRA FACA}. /AVALIAÇÃO DO POTENCIAL TERAPÊUTICO DO PÓ CERÍFERO DA CARNAÚBA { Copemicia cerífero MART.) NO TRATAMENTO DE CAMUNDONGOS HIPERCOLESTEROLÊMICOS INDUZIDOS POR DIETA. /CAM UN DONGOS GENETICAM ENTE MODIFICADOS COMO MODELOS PARA DOENÇA DE ALZHEIM ER. /CINÉTICA DE MARCADORES DO DESEQUILÍBRIO REDOX NO MÚSCULO ESQUELÉTICO DE RATOS WISTAR APÓS UMA SESSÃO DE EXERCÍCIO EXAUSTIVO. /CONTROLE DE PESO CORPORAL E EFEITO HIPOGLICEMIANTE DE COMPOSTOS ISOLADOS DO PÓ CERÍFERO DA CARNAÚBA ( Copernicia cerifera MART.} EM ANIMAIS DIABÉTICOS. /CRESCIMENTO ÓSSEO LONGITUDINAL E MASSA ÓSSEA TOTAL AUMENTAM EM ANIMAIS TREINADOS. /DÉFICIT DE MEMÓRIA EM RATOS SUBMETIDOS À INDUÇÃO A DOENÇA DE ALZHEIMER POR INFUSÃO INTRACEREBRAL DE B-AMILOIDEl-42. /DETERMINAÇÃO DO PERFIL FITOQUIMICO, TOXICIDADE E ATIVIDADE ANTICONVULSIVANTE DASFOLHAS DA Annona muricata L. /DINÂMICA TEMPORAL DO NÍVEL DE GLICOGÊNIO HEPÁTICO APÓS UMA SESSÃO DE EXERCÍCIO FÍSICO MODERADO EM RATOS. /EFEITO DOS ÁCIDOS GRAXOS ESSENCIAIS NO REPARO DE LESÕES DE PELE. /EFEITO DEPRESSOR DO EXTRATO ETANÓLICO DA ALGA VERMELHA Meristiel/a echinocarpa NO SISTEMA NERVOSO CENTRAL. /EFEITO DO 2,2'-AZOBIS (2-AMIDINOPROPANO) SOBRE O MÚSCULO LISO TRAQUEAL DE RATOS: MODELO PARA ESTUDO DO DESEQUILÍBRIO REDOX. /EFEITO DO LIMONENO EM MIOMÉTRIO DE RATAS WISTAR. /EFEITO DO ÓLEO ESSENCIAL DE Hyptis crenata SOBRE ATIVIDADE LOCOMOTORA, EXPLORATÓRIA E ANSIEDADE DE RATOS. /EFEITO DO Platymiscium floribundum VOG SOB A PERDA ÓSSEA ALVEOLAR EM UM ENSAIO PRÉ­ CLÍNICO DE PERIODONTITE. /EFEITO DO TREINAMENTO INTERVALADO DE ALTA INTENSIDADE NO DESEMPENHO EM TESTE DE ESFORÇO. /EFEITOS CICATRIZANTE E ANTINOCICEPTIVO DO VENENO DE Dinoponera quadriceps EM ÚLCERAS CUTÂNEAS EM CAMUNDONGOS

Universidade e redes de atenção à saúde: uma produção de conhecimento no Sistema Único de Saúde

Prefácio de Flávio Adriano Borges MeloComo promover uma formação em saúde sensível e eticamente compromissada com a implementação e o fortalecimento do Sistema Único de Saúde? Como aproximar a formação profissional da realidade da rede de atenção à saúde local? Quais os desafios encontrados na integração entre ensino e serviços? Quais as potencialidades de aprendizagem no contexto do Sistema Único de Saúde? Neste livro são apresentados relatos produzidos por participantes do PET-Saúde e do Pró-Saúde do CCS/UFRB no município de Santo Antônio de Jesus, ao longo dos quais se busca responder a estas e outras questões relevantes para o debate nacional sobre as políticas de saúde

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study.

BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments. METHODS: The Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370. FINDINGS: We enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2-11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for primary outcomes for the 1586 patients with complete baseline and outcome data that were considered for primary analysis. Adjusted odds ratios for ventilation, inotropic support, or death were 1·09 (95% CI 0·75-1·58; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids and 0·93 (0·58-1·47; corrected p value=1·00) for glucocorticoids alone, versus intravenous immunoglobulin alone. Adjusted average hazard ratios for time to improvement were 1·04 (95% CI 0·91-1·20; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids, and 0·84 (0·70-1·00; corrected p value=0·22) for glucocorticoids alone, versus intravenous immunoglobulin alone. Treatment escalation was less frequent for intravenous immunoglobulin plus glucocorticoids (OR 0·15 [95% CI 0·11-0·20]; p<0·0001) and glucocorticoids alone (0·68 [0·50-0·93]; p=0·014) versus intravenous immunoglobulin alone. Persistent fever (from day 2 onward) was less common with intravenous immunoglobulin plus glucocorticoids compared with either intravenous immunoglobulin alone (OR 0·50 [95% CI 0·38-0·67]; p<0·0001) or glucocorticoids alone (0·63 [0·45-0·88]; p=0·0058). Coronary artery aneurysm occurrence and resolution did not differ significantly between treatment groups. INTERPRETATION: Recovery rates, including occurrence and resolution of coronary artery aneurysms, were similar for primary treatment with intravenous immunoglobulin when compared to glucocorticoids or intravenous immunoglobulin plus glucocorticoids. Initial treatment with glucocorticoids appears to be a safe alternative to immunoglobulin or combined therapy, and might be advantageous in view of the cost and limited availability of intravenous immunoglobulin in many countries. FUNDING: Imperial College London, the European Union's Horizon 2020, Wellcome Trust, the Medical Research Foundation, UK National Institute for Health and Care Research, and National Institutes of Health

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030