Aristotle on the Virtue of the Multitude

It is generally believed that one argument advanced by Aristotle in favor of the political authority of the multitude is that large groups can make better decisions by pooling their knowledge than individuals or small groups can make alone. This is supported by two analogies, one apparently involving a "potluck dinner" and the other aesthetic judgment. This article suggests that that interpretation of Aristotle's argument is implausible given the historical context and several features of the text. It argues that Aristotle's support for the rule of the multitude rests not on their superior knowledge but rather on his belief that the virtue of individuals can be aggregated and even amplified when they act collectively. This significantly alters our understanding of Aristotle's political thought and presents a powerful alternative to the epistemic defenses of mass political activity popular today

Rethinking Athenian Democracy

Conventional accounts of classical Athenian democracy represent the assembly as the primary democratic institution in the Athenian political system. This looks reasonable in the light of modern democracy, which has typically developed through the democratization of legislative assemblies. Yet it conflicts with the evidence at our disposal. Our ancient sources suggest that the most significant and distinctively democratic institution in Athens was the courts, where decisions were made by large panels of randomly selected ordinary citizens with no possibility of appeal. This dissertation reinterprets Athenian democracy as “dikastic democracy” (from the Greek dikastēs, “judge”), defined as a mode of government in which ordinary citizens rule principally through their control of the administration of justice. It begins by casting doubt on two major planks in the modern interpretation of Athenian democracy: first, that it rested on a conception of the “wisdom of the multitude” akin to that advanced by epistemic democrats today, and second that it was “deliberative,” meaning that mass discussion of political matters played a defining role. The first plank rests largely on an argument made by Aristotle in support of mass political participation, which I show has been comprehensively misunderstood. The second rests on the interpretation of the verb “bouleuomai” as indicating speech, but I suggest that it meant internal reflection in both the courts and the assembly. The third chapter begins the constructive part of the project by comparing the assembly and courts as instruments of democracy in Athens, and the fourth shows how a focus on the courts reveals the deep political dimensions of Plato’s work, which in turn suggests one reason why modern democratic ideology and practice have moved so far from the Athenians’ on this score. Throughout, the dissertation combines textual, philological and conceptual analysis with attention to institutional detail and the wider historical context. The resulting account makes a strong case for the relevance of classical Athens today, both as a source of potentially useful procedural mechanisms and as the point of origin of some of the philosophical presuppositions on which the modern conception of democracy and its limits depends.Governmen

`Representing and Being Represented in Turn’ - A Symposium on Hélène Landemore’s "Open Democracy"

Hélene Landemore’s Open Democracy challenges today’s democracies to meet their legitimacy deficits by opening up a wide array of participatory opportunities, from enhanced forms of direct democracy, to internet crowdsourcing, to representation through random selection to a citizens’ assembly: “representing and being represented in turn” (p. xvii).  Her aim: to replace citizen consent with citizen power.  The critics advance both praise and misgivings.  Joshua Cohen asks if Landemore's innovations are best understood as supplements or alternatives to the current system. Daniele Cammack argues for the significance of open mass meetings as well as smaller representative bodies. Peter Stone considers citizens’ assemblies inadequate for popular sovereignty.  Christopher Achen warns of problems in accurate representation, through both self-selection into the lottery and domination in the discussion. Ethan Lieb argues that particular innovations are useful only in some contexts, and that in each citizens should learn their appropriate role responsibilities. Landemore responds by agreeing, clarifying and rebutting

Plato and the Construction of Justice

Plato's interest in justice is pronounced and familiar. So too are his criticisms of Athenian democracy. This article suggests that Plato's conceptualization of justice constituted a direct and conscious confrontation with the highly democratic mode of justice pursued in Athens' popular courts. Yet Plato did not resist all Athenian judicial norms. His approach recalls Athenian homicide trials, which operated quite differently from the ordinary kind. Plato's signal contribution to the history of political thought may be characterized as having taken the conception of justice associated with homicide to be paradigmatic, with remarkably enduring effects

Activation by 9-(R)-[2-(Phosphonomethoxy)Propyl]Adenine of Chemokine (RANTES, Macrophage Inflammatory Protein 1α) and Cytokine (Tumor Necrosis Factor Alpha, Interleukin-10 [IL-10], IL-1β) Production

Development of a novel group of antiviral agents, acyclic nucleoside phosphonates, has provided a new perspective for treating human immunodeficiency virus (HIV) infection. One of the compounds, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (PMPA) (tenofovir), has been shown to confer complete protection against AIDS in a simian model of the infection. The aim of our study was to investigate whether the antiviral efficacy of PMPA, which depends mainly on inhibition of virus-induced DNA polymerase or of reverse transcriptase, could be contributed by immunomodulatory potential of this drug. We screened for its ability to activate production of cytokines and chemokines that are known to interfere with the replication and/or the entry of HIV in cells. Using the in vitro test system of mouse macrophages and lymphocytes, it has been found that PMPA stimulates macrophage secretion of interleukin-1β (IL-1β), IL-10, and tumor necrosis factor alpha. Production of the chemokines RANTES and macrophage inflammatory protein 1α was activated in both macrophages and lymphocytes, and also in human cell line U937. Other cytokines—i.e., IL-2, IL-12, IL-13, and gamma interferon—remained uninfluenced by PMPA. The cytokines were stimulated in a dose-dependent fashion, with rapid onset, and peak concentrations were achieved within 5 to 24 h. The findings contribute to a more complex understanding of mechanisms of antiviral effectiveness of PMPA and support the view that this drug could become a promising candidate for therapeutic exploitation in anti-HIV preventive medicine