Childhood abuse and reduced cortical thickness in brain regions involved in emotional processing

Alterations in gray matter development represent a potential pathway through which childhood abuse is associated with psychopathology. Several prior studies find reduced volume and thickness of prefrontal (PFC) and temporal cortex regions in abused compared to non-abused adolescents, although most prior research is based on adults and volume-based measures. The current study tests the hypothesis that child abuse, independent of parental education, predicts reduced cortical thickness in prefrontal and temporal cortices as well as reduced gray mater volume (GMV) in subcortical regions during adolescence

Direct estimations of linear and non-linear functionals of a quantum state

We present a simple quantum network, based on the controlled-SWAP gate, that can extract certain properties of quantum states without recourse to quantum tomography. It can be used used as a basic building block for direct quantum estimations of both linear and non-linear functionals of any density operator. The network has many potential applications ranging from purity tests and eigenvalue estimations to direct characterization of some properties of quantum channels. Experimental realizations of the proposed network are within the reach of quantum technology that is currently being developed.Comment: This paper supersedes the paper quant-ph/0112073, titled "Universal Quantum Estimator". We emphasise the estimation of linear and non-linear functionals of a quantum stat

Synthesis, antimalarial activity in vitro, and docking studies of novel neolignan derivatives

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESThe absence of effective vaccines against malaria and the difficulties associated with controlling mosquito vectors have left chemotherapy as the primary control measure against malaria. However, the emergence and spread of parasite resistance to conventi903464472CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESSEM INFORMAÇÃOSEM INFORMAÇÃOSEM INFORMAÇÃOThe authors thank Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES (CAPES) for financial suppor

Guidance for the integrated use of hydrological, geochemical, and isotopic tools in mining operations

This paper summarizes international state-of-the-art applications and opportunities for employing and deploying hydrological, geochemical, and isotopic tools in an integrated manner for investigations of mining operations. It is intended to aid formulation of more integrated approaches for evaluating the overall sustainability of mining projects. The focus is particularly on mine waters, including: environmental water sources, mine water dynamics, and as a source and vector for pollution in the wider environment. The guidance is generic to mining projects and not just reflective of a particular extraction (e.g. coal, metalliferous, uranium) industry. A mine life cycle perspective has been adopted to highlight the potential for more integrated investigations at each stage of a mining operation. Three types of mines have been considered: new (i.e. those in the planning stage), active (i.e. working mines), and historical mines (i.e. inactive and abandoned mines). The practical usage of geochemical analyses and isotopic studies described here emphasise characterisation, dynamics, and process understanding for water quality considerations in tandem with water resource and environmental impact implications. Both environmental (i.e. ambient) and applied (i.e. injected) tracers are considered. This guide is written for scientists (including isotope specialists) who have limited or no mine water experience, environmental managers, planners, consultants, and regulators with key interests in planned, active, and legacy mining projects.The authors thank the IAEA for inviting us to collate an initial report on guidelines from 2018-06-25–28 in Vienna. We thank Chris Gammons for allowing us to use one of his fgures. We especially thank Umaya Doss Saravana Kumar, Lucia Ortega, and Araguás-Araguás from IAEA for assistance, and Andrea Nick for input during the meeting. Special thanks to our reviewers who substantially helped improve the structure and content of this guidance document

Structural Parameters of Seven SMC Intermediate-Age and Old Star Clusters

We present structural parameters for the seven intermediate-age and old star clusters NGC121, Lindsay 1, Kron 3, NGC339, NGC416, Lindsay 38, and NGC419 in the Small Magellanic Cloud. We fit King profiles and Elson, Fall, and Freeman profiles to both surface-brightness and star count data taken with the Advanced Camera for Surveys aboard the Hubble Space Telescope. Clusters older than 1 Gyr show a spread in cluster core radii that increases with age, while the youngest clusters have relatively compact cores. No evidence for post core collapse clusters was found. We find no correlation between core radius and distance from the SMC center, although consistent with other studies of dwarf galaxies, some relatively old and massive clusters have low densities. The oldest SMC star cluster, the only globular NGC121, is the most elliptical object of the studied clusters. No correlation is seen between ellipticity and distance from the SMC center. The structures of these massive intermediate-age (1-8 Gyr) SMC star clusters thus appear to primarily result from internal evolutionary processes.Comment: 16 pages, 13 figure

COMPI, una herramienta interactiva para la enseñanza de construcción de compiladores

El objetivo es investigar sobre métodos, técnicas y herramientas para construir compiladores en pos de diseñar una herramienta interactiva y visual que se adapte a nuestro entorno cultural y que ayude al alumno en el proceso de enseñanza-aprendizaje, inherente al desarrollo de un compilador.Eje: Tecnología Informática Aplicada en EducaciónRed de Universidades con Carreras en Informática (RedUNCI

COMPI, una herramienta interactiva para la enseñanza de construcción de compiladores

El objetivo es investigar sobre métodos, técnicas y herramientas para construir compiladores en pos de diseñar una herramienta interactiva y visual que se adapte a nuestro entorno cultural y que ayude al alumno en el proceso de enseñanza-aprendizaje, inherente al desarrollo de un compilador.Eje: Tecnología Informática Aplicada en EducaciónRed de Universidades con Carreras en Informática (RedUNCI

COMPI, una herramienta interactiva para la enseñanza de construcción de compiladores

El objetivo es investigar sobre métodos, técnicas y herramientas para construir compiladores en pos de diseñar una herramienta interactiva y visual que se adapte a nuestro entorno cultural y que ayude al alumno en el proceso de enseñanza-aprendizaje, inherente al desarrollo de un compilador.Eje: Tecnología Informática Aplicada en EducaciónRed de Universidades con Carreras en Informática (RedUNCI