Experimental and analytical study of cracks under biaxial fatigue

Most mechanical components experience multi-axial cyclic loading conditions during service. Experimental analysis of fatigue cracks under such conditions is not easy and most works tend to focus more on the simpler but less realistic case of uni-axial loading. Consequently, there are many uncertainties related to the load sequence effect that are now well known and are not normally incorporated into the growth models. The current work presents a new methodology for evaluating overload effect in biaxial fatigue cracks. The methodology includes evaluation of mixed-mode (KI and KII) stress intensity factor and the Crack Opening Displacement for samples with and without overload cycle under biaxial loading. The methodology is tested under a range of crack lengths. All crack-tip information is obtained with a hybrid methodology that combines experimental full-field digital image correlation data and Williams' elastic model describing the crack-tip field.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Dynamical Cluster Quantum Monte Carlo Study of the Single Particle Spectra of Strongly Interacting Fermion Gases

We study the single-particle spectral function of resonantly-interacting fermions in the unitary regime, as described by the three-dimensional attractive Hubbard model in the dilute limit. Our approach, based on the Dynamical Cluster Approximation and the Maximum Entropy Method, shows the emergence of a gap with decreasing temperature, as reported in recent cold-atom photoemission experiments, for coupling values that span the BEC-BCS crossover. By comparing the behavior of the spectral function to that of the imaginary time dynamical pairing susceptibility, we attribute the development of the gap to the formation of local bound atom pairs.Comment: 4 pages, 4 figures, accepted by PRA Rapid Communication

Germination response to various temperature regimes of four Mediterranean seeder shrubs across a range of altitudes

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Spreading of Persistent Infections in Heterogeneous Populations

Up to now, the effects of having heterogeneous networks of contacts have been studied mostly for diseases which are not persistent in time, i.e., for diseases where the infectious period can be considered very small compared to the lifetime of an individual. Moreover, all these previous results have been obtained for closed populations, where the number of individuals does not change during the whole duration of the epidemics. Here, we go one step further and analyze, both analytically and numerically, a radically different kind of diseases: those that are persistent and can last for an individual's lifetime. To be more specific, we particularize to the case of Tuberculosis' (TB) infection dynamics, where the infection remains latent for a period of time before showing up and spreading to other individuals. We introduce an epidemiological model for TB-like persistent infections taking into account the heterogeneity inherent to the population structure. This sort of dynamics introduces new analytical and numerical challenges that we are able to sort out. Our results show that also for persistent diseases the epidemic threshold depends on the ratio of the first two moments of the degree distribution so that it goes to zero in a class of scale-free networks when the system approaches the thermodynamic limit.Comment: 12 pages and 2 figures. Revtex format. Submitted for publication

Tyrosine Hydroxylase and DOPA Decarboxylase Gene Variants in Personality Traits

Personality influences several characteristics of normal and pathologic behaviors and it is associated with neurotransmitter systems that are under genetic control. The dopaminergic system has been proposed to play a role in the modulation of personality traits. In the present study, variants of the tyrosine hydroxylase (TH) and DOPA decarboxylase (DDC) genes (for TH: rs3842727, rs6356; for DDC: rs1451371, rs1470750, rs998850) were investigated in 111 suicide attempters and 289 healthy subjects to assess the involvement of the dopaminergic synthesis pathway in personality traits. No strong evidence was found for the associations between personality and TH or DDC in overall tests. An interaction effect of genotype and diagnosis was present, with TH and DDC SNPs having a greater effect on the respective personality dimensions in the group of suicide attempters. Because of the risk of false positives, these findings should be interpreted with highest caution. Direct replication attempts within independent groups of suicide attempters will help to resolve this question. Copyright (C) 2009 S. Karger AG, Base

Sobrecargas en crecimiento de grietas por fatiga biaxial

El presente trabajo se centra en el estudio de grietas de fatiga bajo cargas biaxiales. Se presenta una nueva metodología para evaluar el efecto de las sobrecargas basada en la evaluación experimental del factor de intensidad de tensiones efectivo y de la apertura de la grieta (Crack Opening Displacement, COD). El estudio se ha realizado en probetas cilíndricas de acero de bajo contenido en carbono sometidas a cargas de tracción y torsión. Los datos experimentales se han obtenido mediante la técnica de correlación de imágenes digitales. Se ha comparado la evolución de la grieta con y sin sobrecarga. Además, se ha utilizado un procedimiento de detección de carga de apertura. Dicho procedimiento se había desarrollado previamente en fatiga uniaxial para el caso biaxial. Dicho procedimiento permite poner de manifiesto el cambio originado por un ciclo de sobrecarga.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

A common mechanism of defective channel trafficking underlying DFNA2 hearing loss result in different cell surface expression levels of KCNQ4 mutants

KCNQ4 mutations underlie DFNA2, a subtype of autosomal dominant hearing loss. We had previously identified the pore-region p.G296S mutation that impaired channel activity in two manners: it greatly reduced surface expression and abolished channel function. Moreover, G296S mutant exerted a strong dominant-negative effect on potassium currents by reducing the channel expression at the cell surface representing the first study to identify a trafficking-dependent dominant mechanism for the loss of KCNQ4 channel function in DFNA2. Here, we have investigated the pathogenic mechanism associated with all the described KCNQ4 mutations (F182L, W242X, E260K, D262V, L274H, W276S, L281S, G285C, G285S and G321S) that are located in different domains of the channel protein. F182L mutant showed a wild type-like cell-surface distribution in transiently transfected NIH3T3 fibroblasts and the recorded currents in Xenopus oocytes resembled those of the wild-type. The remaining KCNQ4 mutants abolished potassium currents, but displayed distinct levels of defective cell-surface expression in NIH3T3 as quantified by flow citometry. Co-localization studies revealed these mutants were retained in the ER, unless W242X, which showed a clear co-localization with Golgi apparatus. Interestingly, this mutation results in a truncated KCNQ4 protein at the S5 transmembrane domain, before the pore region, that escapes the protein quality control in the ER but does not reach the cell surface at normal levels. Currently we are investigating the trafficking behaviour and electrophysiological properties of several KCNQ4 truncated proteins artificially generated in order to identify specific motifs involved in channel retention/exportation. Altogether, our results indicate that a defect in KCNQ4 trafficking is the common mechanism underlying DFNA

Evaluación de la zona plástica en fatiga para un acero bainitico mediante difracción de rayos x

En este artículo se presenta una nueva metodología para medir la zona plástica de una grieta en fatiga. Se han adquirido datos de difracción de rayos X sincrotrón para una probeta Compact Tension de acero bainítico, en el plano medio a través del espesor. Estos datos han sido traducidos a campos 2D de deformación en torno al vértice. Se ha generado un campo de deformación angular artificial para, en consonancia con los anteriores, obtener el campo de deformación equivalente de Von Mises. La aplicación de la ley de comportamiento elástico ha permitido hallar campos de tensión equivalente entorno al vértice de grieta. Así, se permite estimar la zona plástica y sus dimensiones. Finalmente se estudia la precisión de la metodología a través de una comparación con los modelos de zona plástica de Irwin y de Dugdale.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech Los autores agradecen la financiación aportada para la realización de este trabajo al Ministerio de Economía y Competitividad (referencia MAT2016-76951-C2-2-P) y al Fondo Social Europeo a través de la Iniciativa de Empleo Juvenil (referencia UMAJI84)

Elite coaches’ approach to quantifying technical actions and relative participation in volleyball players’ performance

This study sought to identify elite coaches’ perception of the importance of technical actions and the consideration of relative participation to measure individual volleyball players’ performance. An instrument was elaborated to gather the opinions of elite coaches on the importance of technical actions reported by the data volley (excluding setting), as well as considering relative participation. Twenty elite coaches with at least three years of experience in national teams or top leagues participated in the study. Variables considered in the study were analysed using descriptive statistics and reliability was measured with Cronbach’s α and McDonald’s Omega coefficients (> .70). The results assessed the importance of scoring actions, which received values of (1 point). All errors (terminal and continuity) were scored with (−1). Non-scoring actions were given values [.00, .80], except for poor attack (−.35), poor serve (−.60), free freeball (−.60) and reception free (−.50). Relative participation was considered according to the percentage of points and/or contacts played by each athlete. We concluded that for the player’s points and/or contacts, priority is given to actions that win points directly or are excellent, followed by those that contribute to building comfortable attacks, while penalising errors