462 research outputs found

    Why do Tornados and Hail Storms Rest on Weekends?

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    When anthropogenic aerosols over the eastern USA during summertime are at their weekly mid-week peak, tornado and hail storm activity there is also near its weekly maximum. The weekly cycle in storm activity is statistically significant and unlikely to be due to natural variability. The pattern of variability supports the hypothesis that air pollution aerosols invigorate deep convective clouds in a moist, unstable atmosphere, to the extent of inducing production of large hailstones and tornados. This is caused by the effect of aerosols on cloud-drop nucleation, making cloud drops smaller, delaying precipitation-forming processes and their evaporation, and hence affecting cloud dynamics

    Heroin Use and Street Gangs

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    Midweek Increase in U.S. Summer Rain and Storm Heights, Suggests Air Pollution Invigorates Rainstorms

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    Tropical Rainfall Measuring Mission (TRMM) satellite data show a significant midweek increase in summertime rainfall over the southeast U.S., due to afternoon intensification. TRMM radar data show a significant midweek increase in rain area and in the heights reached by afternoon storms. Weekly variations in model-reanalysis wind patterns over the region and in rain-gauge data are consistent with the satellite data. A midweek decrease of rainfall over the nearby Atlantic is also seen. EPA measurements of particulate concentrations show a midweek peak over much of the U.S. These observations are consistent with the theory that anthropogenic air pollution suppresses cloud-drop coalescence and early rainout during the growth of thunderstorms over land, allowing more water to be carried above the 0 C isotherm, where freezing yields additional latent heat, invigorating the storms--most dramatically evidenced by the shift in the midweek distribution of afternoon-storm heights--and producing large ice hydrometeors. The enhanced convection induces regional convergence, uplifting and an overall increase of rainfall. Compensating downward air motion suppresses convection over the adjacent ocean areas. Pre-TRMM-era data suggest that the weekly cycle only became strong enough to be detectable beginning in the 1980's. Rain-gauge data also suggest that a weekly cycle may have been detectable in the 1940's, but with peak rainfall on Sunday or Monday, possibly explained by the difference in composition of aerosol pollution at that time. This "weekend effect" may thus offer climate researchers an opportunity to study the regional climate-scale impact of aerosols on storm development and monsoon-like circulation

    The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

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    The neurovascular unit provides a dynamic interface between the circulation and central nervous system. Disruption of neurovascular integrity occurs in numerous brain pathologies including neurotrauma and ischaemic stroke. Tissue plasminogen activator is a serine protease that converts plasminogen to plasmin, a protease that dissolves blood clots. Besides its role in fibrinolysis, tissue plasminogen activator is abundantly expressed in the brain where it mediates extracellular proteolysis. However, proteolytically active tissue plasminogen activator also promotes neurovascular disruption after ischaemic stroke; the molecular mechanisms of this process are still unclear. Tissue plasminogen activator is naturally inhibited by serine protease inhibitors (serpins): plasminogen activator inhibitor-1, neuroserpin or protease nexin-1 that results in the formation of serpin:protease complexes. Proteases and serpin:protease complexes are cleared through high-affinity binding to low-density lipoprotein receptors, but their binding to these receptors can also transmit extracellular signals across the plasma membrane. The matrix metalloproteinases are the second major proteolytic system in the mammalian brain, and like tissue plasminogen activators are pivotal to neurological function but can also degrade structures of the neurovascular unit after injury. Herein, we show that tissue plasminogen activator potentiates neurovascular damage in a dose-dependent manner in a mouse model of neurotrauma. Surprisingly, inhibition of activity following administration of plasminogen activator inhibitor-1 significantly increased cerebrovascular permeability. This led to our finding that formation of complexes between tissue plasminogen activator and plasminogen activator inhibitor-1 in the brain parenchyma facilitates post-traumatic cerebrovascular damage. We demonstrate that following trauma, the complex binds to low-density lipoprotein receptors, triggering the induction of matrix metalloproteinase-3. Accordingly, pharmacological inhibition of matrix metalloproteinase-3 attenuates neurovascular permeability and improves neurological function in injured mice. Our results are clinically relevant, because concentrations of tissue plasminogen activator: plasminogen activator inhibitor-1 complex and matrix metalloproteinase-3 are significantly elevated in cerebrospinal fluid of trauma patients and correlate with neurological outcome. In a separate study, we found that matrix metalloproteinase-3 and albumin, a marker of cerebrovascular damage, were significantly increased in brain tissue of patients with neurotrauma. Perturbation of neurovascular homeostasis causing oedema, inflammation and cell death is an important cause of acute and long-term neurological dysfunction after trauma. A role for the tissue plasminogen activator-matrix metalloproteinase axis in promoting neurovascular disruption after neurotrauma has not been described thus far. Targeting tissue plasminogen activator: plasminogen activator inhibitor-1 complex signalling or downstream matrix metalloproteinase-3 induction may provide viable therapeutic strategies to reduce cerebrovascular permeability after neurotraum

    Apparent Fractality Emerging from Models of Random Distributions

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    The fractal properties of models of randomly placed nn-dimensional spheres (nn=1,2,3) are studied using standard techniques for calculating fractal dimensions in empirical data (the box counting and Minkowski-sausage techniques). Using analytical and numerical calculations it is shown that in the regime of low volume fraction occupied by the spheres, apparent fractal behavior is observed for a range of scales between physically relevant cut-offs. The width of this range, typically spanning between one and two orders of magnitude, is in very good agreement with the typical range observed in experimental measurements of fractals. The dimensions are not universal and depend on density. These observations are applicable to spatial, temporal and spectral random structures. Polydispersivity in sphere radii and impenetrability of the spheres (resulting in short range correlations) are also introduced and are found to have little effect on the scaling properties. We thus propose that apparent fractal behavior observed experimentally over a limited range may often have its origin in underlying randomness.Comment: 19 pages, 12 figures. More info available at http://www.fh.huji.ac.il/~dani

    Detrainment Dominates CCN Concentrations Around Non Precipitating Convective Clouds Over the Amazon

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    We investigated the relationship between the number concentration of cloud droplets (Nd) in ice-free convective clouds and of particles large enough to act as cloud condensation nuclei (CCN) measured at the lateral boundaries of cloud elements. The data were collected during the ACRIDICON CHUVA aircraft campaign over the Amazon Basin. The results indicate that the CCN particles at the lateral cloud boundaries are dominated by detrainment from the cloud
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