Field Tests of Kairomones to Increase Parasitism of Spruce Budworm (Lepidoptera: Tortricidae) Eggs by \u3ci\u3eTrichogramma\u3c/i\u3e Spp. (Hymenoptera: Trichogrammatidae)

Hexane extracts of spruce budworm, Choristoneura fumiferana, moth scales, applied at 0.04 moth-gram equivalents/branch and at 0.06 moth-gram equivalents/tree, failed to increase parasitism rates of Trichogramma spp. in two cutover spruce-fir stands in Maine. Releasing Maine-strain T. minutum apparently increased parasitism rates about 20-fold. However, application of kairomone extracts to whole branches and to upper crowns of small trees may have interfered with host-searching behaviors of Trichogramma parasitoids

Reproductive Coercion and Relationship Abuse Among Adolescents and Young Women Seeking Care at School Health Centers.

ObjectiveTo investigate demographic differences and evaluate how reproductive coercion and relationship abuse influences young females' care-seeking and sexual health behaviors.MethodsWe conducted a secondary analysis of cross-sectional baseline survey data from sexually active female students (aged 14-19 years) who sought care from school health centers. Outcomes included recent (previous 3 months) reproductive coercion, physical or sexual adolescent relationship abuse, and nonpartner sexual violence victimization. Cluster-adjusted χ tests compared demographics and generalized linear mixed models estimated associations among reproductive coercion, adolescent relationship abuse (physical and sexual abuse in romantic relationships), and care-seeking and sexual health behaviors.ResultsOf 550 sexually active high school females, 12% reported recent reproductive coercion and 17% reported physical or sexual adolescent relationship abuse, with no significant demographic differences. Prevalence of recent nonpartner sexual violence was 17%. There were no observed significant differences in care-seeking behaviors among those with recent reproductive coercion compared with those without. Physical or sexual adolescent relationship abuse was associated with increased odds of seeking testing or treatment for sexually transmitted infections (adjusted odds ratio [aOR] 2.08, 95% CI 1.05-4.13). Females exposed to both adolescent relationship abuse and reproductive coercion had higher odds of having a partner who was 5 or more years older (aOR 4.66, 95% CI 1.51-14.4), having two or more recent sexual partners (aOR 3.86, 95% CI 1.57-9.48), and using hormonal contraception only (aOR 3.77, 95% CI 1.09-13.1 vs hormonal methods with condoms).ConclusionAlmost one in eight females experienced recent reproductive coercion. We did not observe significant demographic differences in reproductive coercion. Partner age and number of sexual partners may elevate risk for abusive relationships. Relationship abuse is prevalent among high school students seeking care, with no clear pattern for case identification. By failing to identify factors associated with harmful partner behaviors, our results support universal assessment for reproductive coercion and relationship abuse among high school-aged adolescents, involving education, resources, and harm-reduction counseling to all patients.Clinical trial registrationClinicalTrials.gov, NCT01678378

Engineering America's Future in Space: Systems Engineering Innovations for Sustainable Exploration

The National Aeronautics and Space Administration (NASA) delivers space transportation solutions for America's complex missions, ranging from scientific payloads that expand knowledge, such as the Hubble Space Telescope, to astronauts and lunar rovers destined for voyages to the Moon. Currently, the venerable Space Shuttle, which has been in service since 1981, provides U.S. capability for both crew and cargo to low-Earth orbit to construct the International Space Station, before the Shuttle is retired in 2010, as outlined in the 2006 NASA Strategic Plan. I In the next decade, NASA will replace this system with a duo of launch vehicles: the Ares I Crew Launch Vehicle/Orion Crew Exploration Vehicle and the Ares V Cargo Launch Vehicle/Altair Lunar Lander. The goals for this new system include increased safety and reliability, coupled with lower operations costs that promote sustainable space exploration over a multi-decade schedule. This paper will provide details of the in-house systems engineering and vehicle integration work now being performed for the Ares I and planned for the Ares V. It will give an overview of the Ares I system-level test activities, such as the ground vibration testing that will be conducted in the Marshall Center's Dynamic Test Stand to verify the integrated vehicle stack's structural integrity against predictions made by modern modeling and simulation analysis. It also will give information about the work in progress for the Ares I-X developmental test flight planned in 2009 to provide key data before the Ares I Critical Design Review. Activities such as these will help prove and refine mission concepts of operation, while supporting the spectrum of design and development tasks being performed by Marshall's Engineering Directorate, ranging from launch vehicles and lunar rovers to scientific spacecraft and associated experiments. Ultimately, the work performed will lead to the fielding of a robust space transportation solution that will carry international explorers and essential payloads for sustainable scientific discovery beyond planet Earth

Bipyrimidine Signatures as a Photoprotective Genome Strategy in G+C-rich Halophilic Archaea

Halophilic Archaea • Experience high levels of ultraviolet (UV) radiation in their environments • Demonstrate high resistance to UV • Are protected by pigmentation and efficient DNA repair • Have high genomic G+C conten

Large family cohorts of lymphoblastoid cells provide a new cellular model for investigating facioscapulohumeral muscular dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) is associated with aberrant epigenetic regulation of the chromosome 4q35 D4Z4 macrosatellite repeat. The resulting DNA hypomethylation and relaxation of epigenetic repression leads to increased expression of the deleterious DUX4-fl mRNA encoded within the distal D4Z4 repeat. With the typical late onset of muscle weakness, prevalence of asymptomatic individuals, and an autosomal dominant mode of inheritance, FSHD is often passed on from one generation to the next and affects multiple individuals within a family. Here we have characterized unique collections of 114 lymphoblastoid cell lines (LCLs) generated from 12 multigenerational FSHD families, including 56 LCLs from large, genetically homogeneous families in Utah. We found robust expression of DUX4-fl in most FSHD LCLs and a good correlation between DNA hypomethylation and repeat length. In addition, DUX4-fl levels can be manipulated using epigenetic drugs as in myocytes, suggesting that some epigenetic pathways regulating DUX4-fl in myocytes are maintained in LCLs. Overall, these FSHD LCLs provide an alternative cellular model in which to study many aspects of D4Z4, DUX4, and FSHD gene regulation in a background of low genetic variation. Significantly, these non-adherent immortal LCLs are amenable for high-throughput screening of potential therapeutics targeting DUX4-fl mRNA or protein expression

Management of COPD in the UK primary-care setting : an analysis of real-life prescribing patterns

Peer reviewedPublisher PD

Low-Speed Fan Noise Attenuation from a Foam-Metal Liner

A foam-metal liner for attenuation of fan noise was developed for and tested on a low-speed fan. This type of liner represents a significant advance over traditional liners, due to the possibility of placement in close proximity to the rotor. An advantage of placing treatment in this region is that the acoustic near field is modified, thereby inhibiting the noise-generation mechanism. This can result in higher attenuation levels than could be achieved by liners located in the nacelle inlet. In addition, foam-metal liners could potentially replace the fan rub strip and containment components, ultimately reducing engine components and thus weight, which can result in a systematic increase in noise reduction and engine performance. Foam-metal liners have the potential to reduce fan noise by 4 dB based on this study

Promoter architecture dictates cell-to-cell variability in gene expression

Variability in gene expression among genetically identical cells has emerged as a central preoccupation in the study of gene regulation; however, a divide exists between the predictions of molecular models of prokaryotic transcriptional regulation and genome-wide experimental studies suggesting that this variability is indifferent to the underlying regulatory architecture. We constructed a set of promoters in Escherichia coli in which promoter strength, transcription factor binding strength, and transcription factor copy numbers are systematically varied, and used messenger RNA (mRNA) fluorescence in situ hybridization to observe how these changes affected variability in gene expression. Our parameter-free models predicted the observed variability; hence, the molecular details of transcription dictate variability in mRNA expression, and transcriptional noise is specifically tunable and thus represents an evolutionarily accessible phenotypic parameter