Rental Housing and the Natural Vacancy Rate

This study uses 1989-2005 data for the Seattle metropolitan area to test the natural vacancy rate hypothesis for rental housing markets using a new methodology. Findings support the existence of a natural vacancy rate for apartments that varies over time, and in some cases across apartment submarkets. Results show a decline in the natural vacancy rate in the time period following the introduction and growth of the Web. Results also show significant differences in natural vacancy rates for different geographic subareas. No significant differences in the natural vacancy rate are found for different apartment types.

07291 Abstracts Collection -- Scientific Visualization

From 15.07. to 20.07.07, the Dagstuhl Seminar 07291 ``Scientific Visualization\u27\u27 was held in the International Conference and Research Center (IBFI),Schloss Dagstuhl. During the seminar, several participants presented their current research, and ongoing work and open problems were discussed. Abstracts of the presentations given during the seminar as well as abstracts of seminar results and ideas are put together in this paper. The first section describes the seminar topics and goals in general. Links to extended abstracts or full papers are provided, if available

The SOUX AGN sample: optical/UV/X-ray SEDs and the nature of the disc

We use the SOUX sample of ∼700 active galactic nucleus (AGN) to form average optical-ultraviolet (UV)-X-rays spectral energy distributions (SEDs) on a two-dimensional (2D) grid of MBH and L2500. We compare these with the predictions of a new AGN SED model, QSOSED, which includes prescriptions for both hot and warm Comptonization regions as well as an outer standard disc. This predicts the overall SED fairly well for 7.5 < log(MBH/M⊙) < 9.0 over a wide range in L/LEdd, but at higher masses the outer disc spectra in the model are far too cool to match the data. We create optical-UV composites from the entire Sloan Digital Sky Survey sample and use these to show that the mismatch is due to there being no significant change in spectral shape of the optical-UV continuum across several decades of MBH at constant luminosity. We show for the first time that this cannot be matched by standard disc models with high black hole spin. These apparently fit, but are not self-consistent as they do not include the General Relativistic effects for the emission to reach the observer. At high spin, increased gravitational redshift compensates for almost all of the higher temperature emission from the smaller inner disc radii. The data do not match the predictions made by any current accretion flow model. Either the disc is completely covered by a warm Comptonization layer whose properties change systematically with L/LEdd, or the accretion flow structure is fundamentally different to that of the standard disc models

The Lyman Alpha Reference Sample. VIII. Characterizing Lyman-Alpha Scattering in Nearby Galaxies

We examine the dust geometry and Ly{\alpha} scattering in the galaxies of the Lyman Alpha Reference Sample (LARS), a set of 14 nearby (0.02 < $z$ < 0.2) Ly{\alpha} emitting and starbursting systems with Hubble Space Telescope Ly{\alpha}, H{\alpha}, and H{\beta} imaging. We find that the global dust properties determined by line ratios are consistent with other studies, with some of the LARS galaxies exhibiting clumpy dust media while others of them show significantly lower Ly{\alpha} emission compared to their Balmer decrement. With the LARS imaging, we present Ly{\alpha}/H{\alpha} and H{\alpha}/H{\beta} maps with spatial resolutions as low as $\sim$ 40 pc, and use these data to show that in most galaxies, the dust geometry is best modeled by three distinct regions: a central core where dust acts as a screen, an annulus where dust is distributed in clumps, and an outer envelope where Ly{\alpha} photons only scatter. We show that the dust that affects the escape of Ly{\alpha} is more restricted to the galaxies' central regions, while the larger Ly{\alpha} halos are generated by scattering at large radii. We present an empirical modeling technique to quantify how much Ly{\alpha} scatters in the halo, and find that this "characteristic" scattering distance correlates with the measured size of the Ly{\alpha} halo. We note that there exists a slight anti-correlation between the scattering distance of Ly{\alpha} and global dust properties.Comment: 32 pages, 51 figures, accepted to Ap

Hadron Spectroscopy with Dynamical Chirally Improved Fermions

We simulate two dynamical, mass degenerate light quarks on 16^3x32 lattices with a spatial extent of 2.4 fm using the Chirally Improved Dirac operator. The simulation method, the implementation of the action and signals of equilibration are discussed in detail. Based on the eigenvalues of the Dirac operator we discuss some qualitative features of our approach. Results for ground state masses of pseudoscalar and vector mesons as well as for the nucleon and delta baryons are presented.Comment: 26 pages, 17 figures, 10 table

Sources and Chemistry of NOₓ in the Upper Troposphere Over the United States

The origin of NOx in the upper troposphere over the central United States is examined using aircraft observations obtained during the SUCCESS campaign in April–May of 1996. Correlations between NOy (sum of NOx and its oxidation products) and CO at 8–12 km altitude indicate that NOx originates primarily from convective transport of polluted boundary layer air. Lightning and aircraft emissions appear to be only minor sources of NOx. Chemical steady state model calculations constrained by local observations of NO underestimate the measured NOx/NOy concentration ratio at 8–12 km altitude by a factor of two on average. The magnitude of the underestimate is correlated with concentrations of condensation nuclei, which we take as a proxy for the age of air in the upper troposphere. We conclude that the NOx/NOy ratio is maintained above chemical steady state by frequent convective injections of fresh NOx from the polluted boundary layer and by the long lifetime of NOx in the upper troposphere (5–10 days). In contrast to previous studies, we find no evidence for fast heterogeneous recycling from HNO3 to NOx in the upper troposphere

Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer

<p>Abstract</p> <p>Background</p> <p>Lung cancer is the leading cause of cancer death in men and women in the United States and Western Europe. Over 160,000 Americans die of this disease every year. The five-year survival rate is 15% – significantly lower than that of other major cancers. Early detection is a key factor in increasing lung cancer patient survival. DNA hypermethylation is recognized as an important mechanism for tumor suppressor gene inactivation in cancer and could yield powerful biomarkers for early detection of lung cancer. Here we focused on developing DNA methylation markers for squamous cell carcinoma of the lung. Using the sensitive, high-throughput DNA methylation analysis technique MethyLight, we examined the methylation profile of 42 loci in a collection of 45 squamous cell lung cancer samples and adjacent non-tumor lung tissues from the same patients.</p> <p>Results</p> <p>We identified 22 loci showing significantly higher DNA methylation levels in tumor tissue than adjacent non-tumor lung. Of these, eight showed highly significant hypermethylation in tumor tissue (p < 0.0001): GDNF, MTHFR, OPCML, TNFRSF25, TCF21, PAX8, PTPRN2 and PITX2. Used in combination on our specimen collection, this eight-locus panel showed 95.6% sensitivity and specificity.</p> <p>Conclusion</p> <p>We have identified 22 DNA methylation markers for squamous cell lung cancer, several of which have not previously been reported to be methylated in any type of human cancer. The top eight markers show great promise as a sensitive and specific DNA methylation marker panel for squamous cell lung cancer.</p

Measurement of the Condensation Coefficient of Water in the UMR Cloud Simulation Chamber

Measurements of the condensation coefficient of water under conditions closely approximating those in natural atmospheric cloud have been made in the cooled-wall UMR cloud simulation chamber. Current measurements disclose a value of condensation coefficient near unity at the outset of the experiment, generally decreasing to lower values (~ .01) as the experiment progresses. The significance of the magnitude of condensation coefficient in atmospheric cloud is briefly discussed

A TLR/AKT/FoxO3 immune tolerance–like pathway disrupts the repair capacity of oligodendrocyte progenitors

Cerebral white matter injury (WMI) persistently disrupts myelin regeneration by oligodendrocyte progenitor cells (OPCs). We identified a specific bioactive hyaluronan fragment (bHAf) that downregulates myelin gene expression and chronically blocks OPC maturation and myelination via a tolerance-like mechanism that dysregulates pro-myelination signaling via AKT. Desensitization of AKT occurs via TLR4 but not TLR2 or CD44. OPC differentiation was selectively blocked by bHAf in a maturation-dependent fashion at the late OPC (preOL) stage by a noncanonical TLR4/TRIF pathway that induced persistent activation of the FoxO3 transcription factor downstream of AKT. Activated FoxO3 selectively localized to oligodendrocyte lineage cells in white matter lesions from human preterm neonates and adults with multiple sclerosis. FoxO3 constraint of OPC maturation was bHAf dependent, and involved interactions at the FoxO3 and MBP promoters with the chromatin remodeling factor Brg1 and the transcription factor Olig2, which regulate OPC differentiation. WMI has adapted an immune tolerance–like mechanism whereby persistent engagement of TLR4 by bHAf promotes an OPC niche at the expense of myelination by engaging a FoxO3 signaling pathway that chronically constrains OPC differentiation