Holomorphic Anomaly in Gauge Theory on ALE space

We consider four-dimensional Omega-deformed N=2 supersymmetric SU(2) gauge theory on A1 space and its lift to five dimensions. We find that the partition functions can be reproduced via special geometry and the holomorphic anomaly equation. Schwinger type integral expressions for the boundary conditions at the monopole/dyon point in moduli space are inferred. The interpretation of the five-dimensional partition function as the partition function of a refined topological string on A1x(local P1xP1) is suggested.Comment: 28 page

Vector boson production at hadron colliders: hard-collinear coefficients at the NNLO

We consider QCD radiative corrections to vector-boson production in hadron collisions. We present the next-to-next-to-leading order (NNLO) result of the hard-collinear coefficient function for the all-order resummation of logarithmically-enhanced contributions at small transverse momenta. The coefficient function controls NNLO contributions in resummed calculations at full next-to-next-to-leading logarithmic accuracy. The same coefficient function is used in applications of the subtraction method to perform fully-exclusive perturbative calculations up to NNLO.Comment: 13, pages, no figures. arXiv admin note: text overlap with arXiv:1106.465

Condensation-induced jumping water drops

Water droplets can jump during vapor condensation on solid benzene near its melting point. This phenomenon, which can be viewed as a kind of micro scale steam engine, is studied experimentally and numerically. The latent heat of condensation transferred at the drop three phase contact line melts the substrate during a time proportional to R the drop radius . The wetting conditions change and a spontaneous jump of the drop results in random direction over length 1.5R, a phenomenon that increases the coalescence events and accelerates the growth. Once properly rescaled by the jump length scale, the growth dynamics is, however, similar to that on a solid surface

Results of the standard set forpulmonary sarcoidosis: Feasibility and multicentre outcomes

Our study presents findings on a previously developed standard set of clinical outcome data for pulmonary sarcoidosis patients. We aimed to assess whether changes in outcome varied between the different centres and to evaluate the feasibility of collecting the standard set retrospectively. This retrospective observational comparative benchmark study included six interstitial lung disease expert centres based in the Netherlands, Belgium, the UK and the USA. The standard set of outcome measures included 1) mortality, 2) changes in pulmonary function (forced vital capacity (FVC), forced expiratory volume in 1 s, diffusing capacity of the lung for carbon monoxide), 3) soluble interleukin-2 receptor (sIL-2R) change, 4) weight changes, 5) quality-of-life (QoL) measures, 6) osteoporosis and 7) clinical outcome status (COS). Data collection was considered feasible if the data were collected in ⩾80% of all patients. 509 patients were included in the retrospective cohort. In total six patients died, with a mean survival of 38±23.4 months after the diagnosis. Centres varied in mean baseline FVC, ranging from 110 (95% CI 92–124)% predicted to 99 (95% CI 97–123)% pred. Mean baseline body mass index (BMI) of patients in the different centres varied between 27 (95% CI 23.6–29.4) kg·m−2 and 31.8 (95% CI 28.1–35.6) kg·m−2. 310 (60.9%) patients were still on systemic therapy 2 years after the diagnosis. It was feasible to measure mortality, changes in pulmonary function, weight changes and COS. It is not (yet) feasible to retrospectively collect sIL-2R, osteoporosis and QoL data internationally. This study shows that data collection for the standard set of outcome measures for pulmonary sarcoidosis was feasible for four out of seven outcome measures. Trends in pulmonary function and BMI were similar for different hospitals when comparing different practices

Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.

Frontometaphyseal dysplasia (FMD) is a progressive sclerosing skeletal dysplasia affecting the long bones and skull. The cause of FMD in some individuals is gain-of-function mutations in FLNA, although how these mutations result in a hyperostotic phenotype remains unknown. Approximately one half of individuals with FMD have no identified mutation in FLNA and are phenotypically very similar to individuals with FLNA mutations, except for an increased tendency to form keloid scars. Using whole-exome sequencing and targeted Sanger sequencing in 19 FMD-affected individuals with no identifiable FLNA mutation, we identified mutations in two genes-MAP3K7, encoding transforming growth factor β (TGF-β)-activated kinase (TAK1), and TAB2, encoding TAK1-associated binding protein 2 (TAB2). Four mutations were found in MAP3K7, including one highly recurrent (n = 15) de novo mutation (c.1454C>T [ p.Pro485Leu]) proximal to the coiled-coil domain of TAK1 and three missense mutations affecting the kinase domain (c.208G>C [p.Glu70Gln], c.299T>A [p.Val100Glu], and c.502G>C [p.Gly168Arg]). Notably, the subjects with the latter three mutations had a milder FMD phenotype. An additional de novo mutation was found in TAB2 (c.1705G>A, p.Glu569Lys). The recurrent mutation does not destabilize TAK1, or impair its ability to homodimerize or bind TAB2, but it does increase TAK1 autophosphorylation and alter the activity of more than one signaling pathway regulated by the TAK1 kinase complex. These findings show that dysregulation of the TAK1 complex produces a close phenocopy of FMD caused by FLNA mutations. Furthermore, they suggest that the pathogenesis of some of the filaminopathies caused by FLNA mutations might be mediated by misregulation of signaling coordinated through the TAK1 signaling complex

Achieving a robust grassy-ELM operation regime in CFETR

We have identified a robust grassy-edge localized mode (ELM) operation regime for future tokamak reactors. The regime exists within a pedestal top electron collisionality (ν *) window at high global poloidal beta (β p). The existence of an upper ν * limit for grassy-ELMs is consistent with results previously reported in experiments (Oyama et al 2010 Nucl. Fusion 50 064014), while the existence of a lower ν * limit has not been reported previously. Using EPED and BOUT  +  +, a theoretical model that quantitatively explains the physics of the grassy-ELMs within the window, which distinguishes them from the small mixed-ELMs at lower ν *, is presented for the first time. A peeling-ballooning stability boundary is obtained by scanning the operating density space. The change in density corresponds to a change in ν * that affects the pedestal bootstrap current. High β p leads to a strong Shafranov shift, which affects the flux surface averaged pressure drive. The two effects combine to create a peeling-dominated window in intermediate ν * buffered by ballooning-dominated regimes. Only the peeling-dominated regime shows a cyclic behavior in the perturbed pressure during the nonlinear simulation of an ELM crash, reminiscent of grassy-ELM dynamics. Similarly, the energy released across the separatrix is demonstrated to be significantly smaller. The quick recovery of the ELM crash is explainable by the rapid rise of a low n kink-peeling instability when the pedestal current Iped exceeds a threshold at high β p. It minimizes the excursion beyond marginal stability and is absent in the ballooning-dominated regime. Comparison with recent experiments over a range of β p and ν * strongly supports the physical picture proposed by the modeling

Consequences of various landscape-scale ecosystem management strategies and fire cycles on age-class structure and harvest in boreal forests

At the landscape scale, one of the key indicators of sustainable forest management is the age-class distribution of stands, since it provides a coarse synopsis of habitat potential, structural complexity, and stand volume, and it is directly modified by timber extraction and wildfire. To explore the consequences of several landscape-scale boreal forest management strategies on age-class structure in the Mauricie region of Quebec, we used spatially explicit simulation modelling. Our study investigated three different harvesting strategies (the one currently practiced and two different strategies to maintain late seral stands) and interactions between fire and harvesting on stand age-class distribution. We found that the legacy of initial forested age structure and its spatial configuration can pose short- (<50 years) to medium-term (150-300 years) challenges to balancing wood supply and ecological objectives. Also, ongoing disturbance by fire, even at relatively long cycles in relation to historic levels, can further constrain the achievement of both timber and biodiversity goals. For example, when fire was combined with management, harvest shortfalls occurred in all scenarios with a fire cycle of 100 years and most scenarios with a fire cycle of 150 years. Even a fire cycle of 500 years led to a reduction in older forest when its maintenance was not a primary constraint. Our results highlight the need to consider the broad-scale effects of natural disturbance when developing ecosystem management policies and the importance of prioritizing objectives when planning for multiple resource use

Classical inflaton field induced creation of superheavy dark matter

We calculate analytically and numerically the production of superheavy dark matter (X) when it is coupled to the inflaton field \phi within the context of a slow-roll m_\phi^2 \phi^2/2 inflationary model with coupling g^2 X^2 \phi^2/2. We find that X particles with a mass as large as 1000 H_i, where H_i is the value of the Hubble expansion rate at the end of inflation, can be produced in sufficient abundance to be cosmologically significant today. This means that superheavy dark matter may have a mass of up to 10^{-3} Planck mass. We also derive a simple formula that can be used to estimate particle production as a result of a quantum field's interaction with a general class of homogeneous classical fields. Finally, we note that the combined effect of the inflaton field and the gravitational field on the X field causes the production to be a nonmonotonic function of g^2.Comment: 42 page LaTeX file with 8 PostScript figures included with eps