Evolution of the Laurentide and Innuitian ice sheets prior to the Last Glacial Maximum (115 ka to 25 ka)

The Laurentide Ice Sheet was the largest global ice mass to grow and decay during the last glacial cycle (~115 ka to ~10 ka). Despite its importance for driving major changes in global mean sea level, long-term landscape evolution, and atmospheric circulation patterns, the history of the Laurentide (and neighbouring Innuitian) Ice Sheet is poorly constrained owing to sporadic preservation of stratigraphic records prior to the Last Glacial Maximum (LGM; ~25 ka) and a case-study approach to the dating of available evidence. Here, we synthesize available geochronological data from the glaciated region, together with published stratigraphic and geomorphological data, as well as numerical modelling output, to derive 19 hypothesised reconstructions of the Laurentide and Innuitian ice sheets from 115 ka to 25 ka at 5-kyr intervals, with uncertainties quantified to include best, minimum, and maximum ice extent estimates at each time-step. Our work suggests that, between 115 ka and 25 ka, some areas of North America experienced multiple cycles of rapid ice sheet growth and decay, while others remained largely ice-free, and others were continuously glaciated. Key findings include: (i) the growth and recession of the Laurentide Ice Sheet from 115 ka through 80 ka; (ii) significant build-up of ice to almost LGM extent at ~60 ka; (iii) a potentially dramatic reduction in North American ice at ~45 ka; (iv) a rapid expansion of the Labrador Dome at ~38 ka; and (v) gradual growth toward the LGM starting at ~35 ka. Some reconstructions are only loosely constrained and are therefore speculative (especially prior to 45 ka). Nevertheless, this work represents our most up-to-date understanding of the build-up of the Laurentide and Innuitian ice sheets during the last glacial cycle to the LGM based on the available evidence. We consider these ice configurations as a series of testable hypotheses for future work to address and refine. These results are important for use across a range of disciplines including ice sheet modelling, palaeoclimatology and archaeology and are available digitally

Last interglacial sea-level proxies in the glaciated Northern Hemisphere

Because global sea level during the last interglacial (LIG; 130–115 ka) was higher than today, the LIG is a useful approximate analogue for improving predictions of future sea-level rise. Here, we synthesize sea-level proxies for the LIG in the glaciated Northern Hemisphere for inclusion in the World Atlas of Last Interglacial Shorelines (WALIS) database. We describe 82 sites from Russia, northern Europe, Greenland and North America from a variety of settings, including boreholes, riverbank exposures and along coastal cliffs. Marine sediments at these sites were constrained to the LIG using a variety of radiometric methods (radiocarbon, uranium–thorium, potassium–argon), non-radiometric methods (amino acid dating, luminescence methods, electron spin resonance, tephrochronology) as well as various stratigraphic and palaeo-environmental approaches. In general, the sites reported in this paper do not offer constraint on the global LIG highstand, but rather evidence of glacial isostatic adjustment (GIA)-influenced sea-level positions following the Marine Isotope Stage 6 glaciation (MIS 6; 191–130 ka). Most of the proxies suggest that sea level was much higher during the LIG than at the present time. Moreover, many of the sites show evidence of regression due to sea-level fall (owing to glacial isostatic uplift), and some also show fluctuations that may reflect regrowth of continental ice or increased influence of the global sea-level signal. In addition to documenting LIG sea-level sites in a large swath of the Northern Hemisphere, this compilation is highly relevant for reconstructing the size of MIS 6 ice sheets through GIA modelling. The database is available at https://doi.org/10.5281/zenodo.5602212 (Dalton et al., 2021).publishedVersio

An updated radiocarbon-based ice margin chronology for the last deglaciation of the North American Ice Sheet Complex

The North American Ice Sheet Complex (NAISC; consisting of the Laurentide, Cordilleran and Innuitian ice sheets) was the largest ice mass to repeatedly grow and decay in the Northern Hemisphere during the Quaternary. Understanding its pattern of retreat following the Last Glacial Maximum is critical for studying many facets of the Late Quaternary, including ice sheet behaviour, the evolution of Holocene landscapes, sea level, atmospheric circulation, and the peopling of the Americas. Currently, the most up-to-date and authoritative margin chronology for the entire ice sheet complex is featured in two publications (Geological Survey of Canada Open File 1574 [Dyke et al., 2003]; ‘Quaternary Glaciations – Extent and Chronology, Part II’ [Dyke, 2004]). These often-cited datasets track ice margin recession in 36 time slices spanning 18 ka to 1 ka (all ages in uncalibrated radiocarbon years) using a combination of geomorphology, stratigraphy and radiocarbon dating. However, by virtue of being over 15 years old, the ice margin chronology requires updating to reflect new work and important revisions. This paper updates the aforementioned 36 ice margin maps to reflect new data from regional studies. We also update the original radiocarbon dataset from the 2003/2004 papers with 1541 new ages to reflect work up to and including 2018. A major revision is made to the 18 ka ice margin, where Banks and Eglinton islands (once considered to be glacial refugia) are now shown to be fully glaciated. Our updated 18 ka ice sheet increased in areal extent from 17.81 to 18.37 million km2, which is an increase of 3.1% in spatial coverage of the NAISC at that time. Elsewhere, we also summarize, region-by-region, significant changes to the deglaciation sequence. This paper integrates new information provided by regional experts and radiocarbon data into the deglaciation sequence while maintaining consistency with the original ice margin positions of Dyke et al. (2003) and Dyke (2004) where new information is lacking; this is a pragmatic solution to satisfy the needs of a Quaternary research community that requires up-to-date knowledge of the pattern of ice margin recession of what was once the world’s largest ice mass. The 36 updated isochrones are available in PDF and shapefile format, together with a spreadsheet of the expanded radiocarbon dataset (n = 5195 ages) and estimates of uncertainty for each interval

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely