Synthesis of Mesoionic [2-(10H-phenothiazinyl)-1,3- dithiolium]phenolates

The 2-(10H-phenothiazinyl) -1,3-dithiol-2-yliu

Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase.

International audienceThe rational structural modification of new substituted indolizin-3-yl(phenyl)methanones 1a-i, 2a-i and 3a-i has greatly improved human farnesyltransferase inhibition. The para-bromophenyl analog 2f bearing an ester unit on the indolizine ring demonstrates the highest inhibition potential, with IC50 value of 1.3±0.2 μM. The amidic series 1a-i proves to be the most promising for future modulations, particularly at the triple bond level

Triflic Acid Catalyzed Intermolecular α-Amination of Pterolactams to Give 5-Arylaminopyrrolidinones via N-Acyliminium Species

International audienceA mild and efficient α-aza-amidoalkylation for the synthesis of 5-arylaminopyrrolidinones is presented. The key step of this reaction is the intermolecular interception of an N-acyliminium species, generated under the acidic conditions, with nitrogen nucleophiles such as N-silylamines. © Georg Thieme Verlag Stuttgart New York

Self-assembled Triazole AIE-Active Nanofibers: Synthesis, Morphology, and Photophysical Properties

A series of seven low molecular weight compounds containing triazole, pyridine-<i>N</i>-oxide, and one substituted aromatic ring linked together by heteroatoms containing spacers was synthesized by click chemistry reaction. The compounds were structurally characterized by FTIR, NMR, as well as single-crystal X-ray diffraction. Their morphologic, thermotropic, and photophysical properties were determined by dynamic light scattering, scanning electron microscopy, atomic force microscopy, polarized light microscopy, UV–vis, and photoluminescence spectroscopy. The triazole derivatives proved to have porous 3D supramolecular architectures determined by an extensive nonclassical hydrogen bonding network. They spontaneously crystallized into long nanofibers and exhibited typical molecular glass behavior, aggregation induced emission as well as crystallization induced emission enhancement