148 research outputs found
Giant group I intron in a mitochondrial genome is removed by RNA back-splicing
publishedVersio
OversĂŠttelse af standarder - Implementering af FĂŠlles sprog standarden i de danske kommuner
I det kommunalpolitiske felt findes et vĂŠld af standarder â eksempelvis The Balanced Scorecard, LEAN-Management, FĂŠlles sprog og mange andre. Standarder er kendetegnet ved, at vĂŠre veldefinerede opskrifter, der kan benyttes af mange organisationer indenfor et felt. Men som artiklen efterviser, benyttes standarder ikke pĂ„ samme mĂ„de overalt. Standarder oversĂŠttes og tilpasses praksis i de lokale organisationer. Det empiriske fokus i artiklen er pĂ„ implementeringen af FĂŠlles sprog standarden i de danske kommuner. Analysen viser blandt andet, at organisatoriske sĂ„vel som aktĂžrbundne ressourcer i organisationen har betydning for, hvorvidt standarder oversĂŠttes eller ej. Artiklen adskiller sig pĂ„ to mĂ„der fra majoriteten af publikationer indenfor litteraturen om organisatoriske oversĂŠttelsesprocesser. Dels benyttes kvantitative data, dels arbejdes der pĂ„ det teoretiske plan med en kobling mellem sociologisk institutionel teori og aktĂžrbaseret institutionalisme
Embryogenesis and Larval Biology of the Cold-WaterCoral Lophelia pertusa
Cold-water coral reefs form spectacular and highly diverse ecosystems in the deep sea but little is known about
reproduction, and virtually nothing about the larval biology in these corals. This study is based on data from two locations
of the North East Atlantic and documents the first observations of embryogenesis and larval development in Lophelia
pertusa, the most common framework-building cold-water scleractinian. Embryos developed in a more or less organized
radial cleavage pattern from ,160 mm large neutral or negatively buoyant eggs, to 120â270 mm long ciliated planulae.
Embryogenesis was slow with cleavage occurring at intervals of 6â8 hours up to the 64-cell stage. Genetically characterized
larvae were sexually derived, with maternal and paternal alleles present. Larvae were active swimmers (0.5 mm s21) initially
residing in the upper part of the water column, with bottom probing behavior starting 3â5 weeks after fertilization.
Nematocysts had developed by day 30, coinciding with peak bottom-probing behavior, and possibly an indication that
larvae are fully competent to settle at this time. Planulae survived for eight weeks under laboratory conditions, and
preliminary results indicate that these planulae are planktotrophic. The late onset of competency and larval longevity
suggests a high dispersal potential. Understanding larval biology and behavior is of paramount importance for biophysical
modeling of larval dispersal, which forms the basis for predictions of connectivity among populations
Global Strain in Severe Aortic Valve Stenosis:Relation to Clinical Outcome after Aortic Valve Replacement
Plasma osteoprotegerin is related to carotid and peripheral arterial disease, but not to myocardial ischemia in type 2 diabetes mellitus
<p>Abstract</p> <p>Background</p> <p>Cardiovascular disease (CVD) is frequent in type 2 diabetes mellitus patients due to accelerated atherosclerosis. Plasma osteoprotegerin (OPG) has evolved as a biomarker for CVD. We examined the relationship between plasma OPG levels and different CVD manifestations in type 2 diabetes.</p> <p>Methods</p> <p>Type 2 diabetes patients without known CVD referred consecutively to a diabetes clinic for the first time (n = 305, aged: 58.6 ± 11.3 years, diabetes duration: 4.5 ± 5.3 years) were screened for carotid arterial disease, peripheral arterial disease, and myocardial ischemia by means of carotid artery ultrasonography, peripheral ankle and toe systolic blood pressure measurements, and myocardial perfusion scintigraphy (MPS). In addition, plasma OPG concentrations and other CVD-related markers were measured.</p> <p>Results</p> <p>The prevalence of carotid arterial disease, peripheral arterial disease, and myocardial ischemia was 42%, 15%, and 30%, respectively. Plasma OPG was significantly increased in patients with carotid and peripheral arterial disease compared to patients without (p < 0.001, respectively), however, this was not the case for patients with myocardial ischemia versus those without (p = 0.71). When adjusted for age, HbA1c and U-albumin creatinine ratio in a multivariate logistic regression analysis, plasma OPG remained strongly associated with carotid arterial disease (adjusted OR: 2.12; 95% CI: 1.22-3.67; p = 0.008), but not with peripheral arterial disease or myocardial ischemia.</p> <p>Conclusions</p> <p>Increased plasma OPG concentration is associated with carotid and peripheral arterial disease in patients with type 2 diabetes, whereas no relation is observed with respect to myocardial ischemia on MPS. The reason for this discrepancy is unknown.</p> <p>Trial registration number</p> <p>at <url>http://www.clinicaltrial.gov</url>: <a href="http://www.clinicaltrials.gov/ct2/show/NCT00298844">NCT00298844</a></p
Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase
AbstractCytochrome P450 2A6 (CYP2A6) is a polymorphic enzyme responsible for the oxidation of certain precarcinogens and drugs and is the major nicotine C-oxidase. The role of CYP2A6 for nicotine elimination was emphasised recently by the finding that smokers carrying defective CYP2A6 alleles consumed fewer cigarettes [Pianezza et al. (1998) Nature 393, 750]. The method used for CYP2A6 genotyping has, however, been found to give erroneous results with respect to the coumarin hydroxylase phenotype, a probe reaction for the CYP2A6 enzyme. The present study describes an allele-specific PCR genotyping method that identifies the major defective CYP2A6 allele and accurately predicts the phenotype. An allele frequency of 1â3% was observed in Finnish, Spanish, and Swedish populations, much lower than described previously
Left Ventricular Diastolic Function in Type 2 Diabetes Mellitus: Prevalence and Association with Myocardial and Vascular Disease
Isolation and characterization of nuclear microsatellite loci in the northern shrimp, Pandalus borealis
Published version of an article published in the journal: Conservation Genetics Resources. Also available from the publisher at: http://dx.doi.org/10.1007/s12686-011-9486-4We developed and characterized 20 microsatellite primer loci for the northern shrimp Pandalus borealis. All 20 loci were polymorphic with number of alleles ranging from 3 to 36 and with observed heterozygosity between 0.04 and 0.93. In addition, we tested the utility of these markers in three related shrimp species, P. montagui, Atlantopandalus propinqvus and Dichelopandalus bonnieri. These new markers will prove useful in the identification of stock structure and hence, assessment of the commercially important species P. borealis
- âŠ