On fractional order models for Hepatitis C

In this paper we present a fractional order generalization of Perelson et al. basic hepatitis C virus (HCV) model including an immune response term. We argue that fractional order equations are more suitable than integer order ones in modeling complex systems which include biological systems. The model is presented and discussed. Also we argue that the added immune response term represents some basic properties of the immune system and that it should be included to study longer term behavior of the disease

Carbon monoxide intoxication from domestic fuel-burning furncaces and appliances

The aim of this research paper is to determine if dwellers of rural areas who cook using fuel-burning furnaces and appliances such as woods, charcoal and natural gas are exposed to carbon monoxide (CO) intoxication and to measure the extent of CO intoxication on dwellers resulting from their cooking activities. The data on CO concentration and health problems for this research study were gathered through the means of observation and interview. Samplings were also carried out to measure the CO level at the selected areas, which were identified based on the criteria of the research. These two steps were done concurrently. The measurements of CO in the houses at Kampong Orang Asli Simpang Arang, Gelang Patah residential were taken outside of the houses, inside the kitchen areas before switching the stove on, after the stove was switched on, during the cooking process and after the cooking was completed. The study shows that the dwellers of rural areas who cook using woods as cooking fuels are found to be exposed to CO intoxication and the factors that influence the health risks are duration of cooking activities per meal, frequency of cooking activities, the absence of proper ventilation as well as the amount of CO concentration released during cooking activities. The measured CO concentration from woods during the experiment was in the range of 150 to 500 ppm. Through CO samplings of charcoal and natural gas as control experiments, it is also found that both sources did not contribute to any serious health effects to the people using them as cooking fuels. Meanwhile, the average CO toxicant produced from burning woods was the highest and this indicates that the CO level from woods is the most risky one among the other domestic fuels commonly used

New Rotation Periods in the Pleiades: Interpreting Activity Indicators

We present results of photometric monitoring campaigns of G, K and M dwarfs in the Pleiades carried out in 1994, 1995 and 1996. We have determined rotation periods for 18 stars in this cluster. In this paper, we examine the validity of using observables such as X-ray activity and amplitude of photometric variations as indicators of angular momentum loss. We report the discovery of cool, slow rotators with high amplitudes of variation. This contradicts previous conclusions about the use of amplitudes as an alternate diagnostic of the saturation of angular momentum loss. We show that the X-ray data can be used as observational indicators of mass-dependent saturation in the angular momentum loss proposed on theoretical grounds

The regeneration of stellar bars by tidal interactions. Numerical simulations of fly-by encounters

We study the regeneration of stellar bars triggered by a tidal interaction, using numerical simulations of either purely stellar or stellar+gas disc galaxies. We find that interactions which are sufficiently strong to regenerate the bar in the purely stellar models do not lead to a regeneration in the dissipative models, owing to the induced gas inflow in those models. In models in which the bar can be regenerated, we find a tight correlation between the strength and the pattern speed of the induced bar. This relation can be explained by a significant radial redistribution of angular momentum in the disc due to the interaction, similar to the processes and correlations found for isolated barred spirals. We furthermore show that the regenerated bars show the same dynamical properties as their isolated counterparts.Comment: 18 pages, 26 figures, accepted for publication in MNRA

Viral Kinetics Suggests a Reconciliation of the Disparate Observations of the Modulation of Claudin-1 Expression on Cells Exposed to Hepatitis C Virus

The tight junction protein claudin-1 (CLDN1) is necessary for hepatitis C virus (HCV) entry into target cells. Recent studies have made disparate observations of the modulation of the expression of CLDN1 on cells following infection by HCV. In one study, the mean CLDN1 expression on cells exposed to HCV declined, whereas in another study HCV infected cells showed increased CLDN1 expression compared to uninfected cells. Consequently, the role of HCV in modulating CLDN1 expression, and hence the frequency of cellular superinfection, remains unclear. Here, we present a possible reconciliation of these disparate observations. We hypothesized that viral kinetics and not necessarily HCV-induced receptor modulation underlies these disparate observations. To test this hypothesis, we constructed a mathematical model of viral kinetics in vitro that mimicked the above experiments. Model predictions provided good fits to the observed evolution of the distribution of CLDN1 expression on cells following exposure to HCV. Cells with higher CLDN1 expression were preferentially infected and outgrown by cells with lower CLDN1 expression, resulting in a decline of the mean CLDN1 expression with time. At the same time, because the susceptibility of cells to infection increased with CLDN1 expression, infected cells tended to have higher CLDN1 expression on average than uninfected cells. Our study thus presents an explanation of the disparate observations of CLDN1 expression following HCV infection and points to the importance of considering viral kinetics in future studies of receptor expression on cells exposed to HCV

The CIDA Variability Survey of Orion OB1. I: the low-mass population of Ori OB 1a and 1b

We present results of a large scale, multi-epoch optical survey of the Ori OB1 association, carried out with the QuEST camera at the Venezuela National Astronomical Observatory. We identify for the first time the widely spread low-mass, young population in the Orion OB1a and OB1b sub-associations. Candidate members were picked up by their variability in the V-band and position in color-magnitude diagrams. We obtained spectra to confirm membership. In a region spanning ~ 68 deg^2 we found 197 new young stars; of these, 56 are located in the Ori OB1a subassociation and 142 in Ori OB1b. Comparison with the spatial extent of molecular gas and extinction maps indicates that the subassociation Ori 1b is concentrated within a ring-like structure of radius ~2 deg (~15 pc at 440 pc), centered roughly on the star epsilon Ori in the Orion belt. The ring is apparent in 13CO and corresponds to a region with an extinction Av>=1. The stars exhibiting strong Ha emission, an indicator of active accretion, are found along this ring, while the center is populated with weak Ha emitting stars. In contrast, Ori OB1a is located in a region devoid of gas and dust. We identify a grouping of stars within a ~3 deg^2 area located in 1a, roughly clustered around the B2 star 25 Ori. The Herbig Ae/Be star V346 Ori is also associated with this grouping, which could be an older analog of sigma Ori. Using using several sets of evolutionary tracks we find an age of 7 - 10 Myr for Ori 1a and of ~4 - 6 Myr for Ori OB1b, consistent with previous estimates from OB stars. Indicators such as the equivalent width of Ha and near-IR excesses show that while a substantial fraction of accreting disks remain at ages ~5 Myr, inner disks are essentially dissipated by 10 Myr.Comment: 44 pages, 12 figures, to appear in the Astronomical Journal. (Abridged abstract - to fit length limit in astroph) Full resolution figures in http://www.cida.ve/~briceno/publications

New rotation periods in the Pleiades: Interpreting activity indicators

We present results of photometric monitoring campaigns of G, K and M dwarfs in the Pleiades carried out in 1994, 1995 and 1996. We have determined rotation periods for 18 stars in this cluster. In this paper, we examine the validity of using observables such as X-ray activity and amplitude of photometric variations as indicators of angular momentum loss. We report the discovery of cool, slow rotators with high amplitudes of variation. This contradicts previous conclusions about the use of amplitudes as an alternate diagnostic of the saturation of angular momentum loss. We show that the X-ray data can be used as observational indicators of mass-dependent saturation in the angular momentum loss proposed on theoretical grounds.Comment: 24 pages, LaTex (AASTeX); includes 8 postscript figures and 4 Latex tables. To appear in ApJ, Feb. 1, 1998. Postscript version of preprint can be obtained from http://casa.colorado.edu/~anitak/pubs.htm

VISIR/VLT mid-infrared imaging of Seyfert nuclei: Nuclear dust emission and the Seyfert-2 dichotomy

Half of the Seyfert-2 galaxies escaped detection of broad lines in their polarised spectra observed so far. Some authors have suspected that these non-HBLRs contain real Sy2 nuclei without intrinsic broad line region hidden behind a dust torus. If this were true, then their nuclear structure would fundamentally differ from that of Sy2s with polarised broad lines: in particular, they would not be explained by orientation-based AGN unification. Further arguments for two physically different Sy2 populations have been derived from the warm and cool IRAS F25/F60 ratios. These ratios, however, refer to the entire host galaxies and are unsuitable to conclusively establish the absence of a nuclear dust torus. Instead, a study of the Seyfert-2 dichotomy should be performed on the basis of nuclear properties only. Here we present the first comparison between [OIII] 5007A and mid-infrared imaging at matching spatial resolution. Exploring the Seyfert-2 dichotomy we find that the distributions of nuclear mid-infrared/[OIII] luminosity ratios are indistinguishable for Sy1s and Sy2s with and without detected polarised broad lines and irrespective of having warm or cool IRAS F25/F60 ratios. We find no evidence for the existence of a population of real Sy2s with a deficit of nuclear dust emission. Our results suggest 1) that all Seyfert nuclei possess the same physical structure including the putative dust torus and 2) that the cool IRAS colours are caused by a low contrast of AGN to host galaxy. Then the Seyfert-2 dichotomy is explained in part by unification of non-HBLRs with narrow-line Sy1s and to a larger rate by observational biases caused by a low AGN/host contrast and/or an unfavourable scattering geometry.Comment: 11 pages, 6 figures, accepted by A&

From Biology to Mathematical Models and Back: Teaching Modeling to Biology Students, and Biology to Math and Engineering Students

We describe the development of a course to teach modeling and mathematical analysis skills to students of biology and to teach biology to students with strong backgrounds in mathematics, physics, or engineering. The two groups of students have different ways of learning material and often have strong negative feelings toward the area of knowledge that they find difficult. To give students a sense of mastery in each area, several complementary approaches are used in the course: 1) a “live” textbook that allows students to explore models and mathematical processes interactively; 2) benchmark problems providing key skills on which students make continuous progress; 3) assignment of students to teams of two throughout the semester; 4) regular one-on-one interactions with instructors throughout the semester; and 5) a term project in which students reconstruct, analyze, extend, and then write in detail about a recently published biological model. Based on student evaluations and comments, an attitude survey, and the quality of the students' term papers, the course has significantly increased the ability and willingness of biology students to use mathematical concepts and modeling tools to understand biological systems, and it has significantly enhanced engineering students' appreciation of biology

The Fueling and Evolution of AGN: Internal and External Triggers

In this chapter, I review the fueling and evolution of active galactic nuclei (AGN) under the influence of internal and external triggers, namely intrinsic properties of host galaxies (morphological or Hubble type, color, presence of bars and other non-axisymmetric features, etc) and external factors such as environment and interactions. The most daunting challenge in fueling AGN is arguably the angular momentum problem as even matter located at a radius of a few hundred pc must lose more than 99.99 % of its specific angular momentum before it is fit for consumption by a BH. I review mass accretion rates, angular momentum requirements, the effectiveness of different fueling mechanisms, and the growth and mass density of black BHs at different epochs. I discuss connections between the nuclear and larger-scale properties of AGN, both locally and at intermediate redshifts, outlining some recent results from the GEMS and GOODS HST surveys.Comment: Invited Review Chapter to appear in LNP Volume on "AGN Physics on All Scales", Chapter 6, in press. 40 pages, 12 figures. Typo in Eq 5 correcte