1,198 research outputs found
Peer-to-Peer Secure Multi-Party Numerical Computation Facing Malicious Adversaries
We propose an efficient framework for enabling secure multi-party numerical
computations in a Peer-to-Peer network. This problem arises in a range of
applications such as collaborative filtering, distributed computation of trust
and reputation, monitoring and other tasks, where the computing nodes is
expected to preserve the privacy of their inputs while performing a joint
computation of a certain function. Although there is a rich literature in the
field of distributed systems security concerning secure multi-party
computation, in practice it is hard to deploy those methods in very large scale
Peer-to-Peer networks. In this work, we try to bridge the gap between
theoretical algorithms in the security domain, and a practical Peer-to-Peer
deployment.
We consider two security models. The first is the semi-honest model where
peers correctly follow the protocol, but try to reveal private information. We
provide three possible schemes for secure multi-party numerical computation for
this model and identify a single light-weight scheme which outperforms the
others. Using extensive simulation results over real Internet topologies, we
demonstrate that our scheme is scalable to very large networks, with up to
millions of nodes. The second model we consider is the malicious peers model,
where peers can behave arbitrarily, deliberately trying to affect the results
of the computation as well as compromising the privacy of other peers. For this
model we provide a fourth scheme to defend the execution of the computation
against the malicious peers. The proposed scheme has a higher complexity
relative to the semi-honest model. Overall, we provide the Peer-to-Peer network
designer a set of tools to choose from, based on the desired level of security.Comment: Submitted to Peer-to-Peer Networking and Applications Journal (PPNA)
200
The NiSi melting curve to 70 GPa
The melting curve of NiSi has been determined to 70 GPa on the basis of laser-heated diamond anvil cell (LH-DAC) experiments in which changes in the gradient of temperature vs. laser power functions were used as the melting criterion. The melting curve was corroborated with in situ X-ray diffraction experiments in both the LH-DAC and multi-anvil press in which the appearance of liquid diffuse scattering in the diffraction patterns was used as the melting criterion. At all pressures, the NiSi melting curve is lower than that of FeSi, with the difference in melting temperature reaching a maximum of 900 K at 14 GPa. The location of the B31 + B20 + L triple point has been constrained to 12 ± 2 GPa and 1550 ± 100 K and the B20 + B2 + L triple point to 28.5 ± 1.5 GPa and 2165 ± 60 K. On the basis of the in situ LH-DAC experiments the Clapeyron slope of the B20 → B2 transition is estimated at −67 MPa K−1. Extrapolation of the B2-NiSi liquidus to core-mantle boundary (CMB) conditions (135 GPa) suggests the melting point of NiSi (3700 ± 400 K) will be only marginally lower than that of isostructural FeSi (4000 ± 200 K). Thus any (Fe,Ni)Si solid solution present within the D″ layer is expected to remain solid, with the possible exception of the very hottest region adjacent to the CMB
Fractional quantum Hall effect in the absence of Landau levels
It has been well-known that topological phenomena with fractional
excitations, i.e., the fractional quantum Hall effect (FQHE) \cite{Tsui1982}
will emerge when electrons move in Landau levels. In this letter, we report the
discovery of the FQHE in the absence of Landau levels in an interacting fermion
model. The non-interacting part of our Hamiltonian is the recently proposed
topologically nontrivial flat band model on the checkerboard lattice
\cite{sun}. In the presence of nearest-neighboring repulsion (), we find
that at 1/3 filling, the Fermi-liquid state is unstable towards FQHE. At 1/5
filling, however, a next-nearest-neighboring repulsion is needed for the
occurrence of the 1/5 FQHE when is not too strong. We demonstrate the
characteristic features of these novel states and determine the phase diagram
correspondingly.Comment: 6 pages and 4 figure
Nebulized antibiotics for ventilator-associated pneumonia: misleading analysis and interpretation of the data
The phylogenetically-related pattern recognition receptors EFR and XA21 recruit similar immune signaling components in monocots and dicots
During plant immunity, surface-localized pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs). The transfer of PRRs between plant species is a promising strategy for engineering broad-spectrum disease resistance. Thus, there is a great interest in understanding the mechanisms of PRR-mediated resistance across different plant species. Two well-characterized plant PRRs are the leucine-rich repeat receptor kinases (LRR-RKs) EFR and XA21 from Arabidopsis thaliana (Arabidopsis) and rice, respectively. Interestingly, despite being evolutionary distant, EFR and XA21 are phylogenetically closely related and are both members of the sub-family XII of LRR-RKs that contains numerous potential PRRs. Here, we compared the ability of these related PRRs to engage immune signaling across the monocots-dicots taxonomic divide. Using chimera between Arabidopsis EFR and rice XA21, we show that the kinase domain of the rice XA21 is functional in triggering elf18-induced signaling and quantitative immunity to the bacteria Pseudomonas syringae pv. tomato (Pto) DC3000 and Agrobacterium tumefaciens in Arabidopsis. Furthermore, the EFR:XA21 chimera associates dynamically in a ligand-dependent manner with known components of the EFR complex. Conversely, EFR associates with Arabidopsis orthologues of rice XA21-interacting proteins, which appear to be involved in EFR-mediated signaling and immunity in Arabidopsis. Our work indicates the overall functional conservation of immune components acting downstream of distinct LRR-RK-type PRRs between monocots and dicots
Caspofungin Use in Daily Clinical Practice for Treatment of Invasive Aspergillosis: Results of a Prospective Observational Registry
<p>Abstract</p> <p>Background</p> <p>A prospective observational registry assessed real world experience with caspofungin monotherapy or combination therapy for the initial or salvage treatment of proven or probable invasive aspergillosis (IA).</p> <p>Methods</p> <p>Data were collected from April 2006 to September 2007 for patients treated with caspofungin for a single episode of IA. Clinical effectiveness was categorized as favorable (complete or partial) or unfavorable (stable disease or failure) at the end of caspofungin therapy (EOCT).</p> <p>Results</p> <p>Consecutive patients (n = 103) with proven or probable IA (per EORTC/MSG criteria) were identified from 11 countries. Malignancy (76.7%), neutropenia (64.1%), allogeneic hematopoietic stem cell transplantation (HSCT, 22.3%), solid organ transplantation (8.7%), autologous HSCT (4.9%), and HIV/AIDS (2.9%) were the most common underlying conditions. Most patients (84.5%) had pulmonary IA. <it>Aspergillus fumigatus </it>was the most frequently isolated species. The majority of patients received caspofungin monotherapy (82.5%) primarily as salvage therapy (82.4%). The main reason for switching to salvage therapy was clinical failure of the first-line therapy (69%). A favorable response at EOCT was seen in 56.4% (57/101) of patients overall, including 56.5% (48/85) and 56.3% (9/16) of patients receiving caspofungin monotherapy and combination therapy, respectively. Favorable response rates in clinically relevant subgroups were: malignancy, 51.9% (41/79); allogeneic HSCT, 56.5% (13/23); and neutropenia at time of hospitalization, 53.0% (35/66). There was a 72.3% (73/101) survival at 7 days after EOCT. Serious adverse events related to caspofungin were reported in 4 cases (3.9%); 3 patients (2.9%) discontinued treatment due to an adverse event related to caspofungin.</p> <p>Conclusions</p> <p>Caspofungin was both effective and well tolerated among high-risk patient groups such as those with neutropenia and active malignancies.</p
Joint source and relay design for MIMO multi-relay systems using projected gradient approach
In this paper, we develop the optimal source precoding matrix and relay amplifying matrices for non-regenerative multiple-input multiple-output (MIMO) relay communication systems with parallel relay nodes using the projected gradient (PG) approach. We show that the optimal relay amplifying matrices have a beamforming structure. Exploiting the structure of relay matrices, an iterative joint source and relay matrices optimization algorithm is developed to minimize the mean-squared error (MSE) of the signal waveform estimation at the destination using the PG approach. The performance of the proposed algorithm is demonstrated through numerical simulations
Plant growth retardation and conserved miRNAs are correlated to hibiscus chlorotic ringspot virus infection
10.1371/journal.pone.0085476PLoS ONE812-POLN
Optimised Anaesthesia to Reduce Post Operative Cognitive Decline (POCD) in Older Patients Undergoing Elective Surgery, a Randomised Controlled Trial
Background
The study determined the one year incidence of post operative cognitive decline (POCD) and evaluated the effectiveness of an intra-operative anaesthetic intervention in reducing post-operative cognitive impairment in older adults (over 60 years of age) undergoing elective orthopaedic or abdominal surgery.
Methods and Trial Design
The design was a prospective cohort study with a nested randomised, controlled intervention trial, using intra-operative BiSpectral index and cerebral oxygen saturation monitoring to enable optimisation of anaesthesia depth and cerebral oxygen saturation in older adults undergoing surgery.
Results
In the 52 week prospective cohort study (192 surgical patients and 138 controls), mild (?2 = 17.9 p<0.0001), moderate (?2 = 7.8 p = 0.005) and severe (?2 = 5.1 p = 0.02) POCD were all significantly higher after 52 weeks in the surgical patients than among the age matched controls. In the nested RCT, 81 patients were randomized, 73 contributing to the data analysis (34 intervention, 39 control). In the intervention group mild POCD was significantly reduced at 1, 12 and 52 weeks (Fisher’s Exact Test p = 0.018, ?2 = 5.1 p = 0.02 and ?2 = 5.9 p = 0.015), and moderate POCD was reduced at 1 and 52 weeks (?2 = 4.4 p = 0·037 and ?2 = 5.4 p = 0.02). In addition there was significant improvement in reaction time at all time-points (Vigilance Reaction Time MWU Z = ?2.1 p = 0.03, MWU Z = ?2.7 p = 0.004, MWU Z = ?3.0 p = 0.005), in MMSE at one and 52 weeks (MWU Z = ?2.9 p = 0.003, MWU Z = ?3.3 p = 0.001), and in executive function at 12 and 52 weeks (Trail Making MWU Z = ?2.4 p = .0.018, MWU Z = ?2.4 p = 0.019).
Conclusion
POCD is common and persistent in older adults following surgery. The results of the nested RCT indicate the potential benefits of intra-operative monitoring of anaesthetic depth and cerebral oxygenation as a pragmatic intervention to reduce post-operative cognitive impairment
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