1,604 research outputs found
Noncommutative geometry inspired black holes in higher dimensions at the LHC
When embedding models of noncommutative geometry inspired black holes into
the peridium of large extra dimensions, it is natural to relate the
noncommutativity scale to the higher-dimensional Planck scale. If the Planck
scale is of the order of a TeV, noncommutative geometry inspired black holes
could become accessible to experiments. In this paper, we present a detailed
phenomenological study of the production and decay of these black holes at the
Large Hadron Collider (LHC). Noncommutative inspired black holes are relatively
cold and can be well described by the microcanonical ensemble during their
entire decay. One of the main consequences of the model is the existence of a
black hole remnant. The mass of the black hole remnant increases with
decreasing mass scale associated with noncommutative and decreasing number of
dimensions. The experimental signatures could be quite different from previous
studies of black holes and remnants at the LHC since the mass of the remnant
could be well above the Planck scale. Although the black hole remnant can be
very heavy, and perhaps even charged, it could result in very little activity
in the central detectors of the LHC experiments, when compared to the usual
anticipated black hole signatures. If this type of noncommutative inspired
black hole can be produced and detected, it would result in an additional mass
threshold above the Planck scale at which new physics occurs.Comment: 21 pages, 7 figure
CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity
Background: Primary Sjögren’s syndrome (pSS) is a common chronic autoimmune disease characterized by
lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation. In the current study, we
aimed to investigate the possible pathogenic implication of autophagy in T lymphocytes in patients with pSS.
Methods: Thirty consecutive pSS patients were recruited together with 20 patients affected by sicca syndrome a
nd/or chronic sialoadenitis and 30 healthy controls. Disease activity and damage were evaluated according to SS
disease activity index, EULAR SS disease activity index, and SS disease damage index. T lymphocytes were analyzed
for the expression of autophagy-specific markers by biochemical, molecular, and histological assays in peripheral
blood and labial gland biopsies. Serum interleukin (IL)-23 and IL-21 levels were quantified by enzyme-linked
immunosorbent assay.
Results: Our study provides evidence for the first time that autophagy is upregulated in CD4+ T lymphocyte salivary
glands from pSS patients. Furthermore, a statistically significant correlation was detected between lymphocyte
autophagy levels, disease activity, and damage indexes. We also found a positive correlation between autophagy
enhancement and the increased salivary gland expression of IL-21 and IL-23, providing a further link between innate
and adaptive immune responses in pSS.
Conclusions: These findings suggest that CD4+ T lymphocyte autophagy could play a key role in pSS pathogenesis.
Additionally, our data highlight the potential exploitation of T cell autophagy as a biomarker of disease activity and
provide new ground to verify the therapeutic implications of autophagy as an innovative drug target in pSS
Brane-world black holes and the scale of gravity
A particle in four dimensions should behave like a classical black hole if
the horizon radius is larger than the Compton wavelength or, equivalently, if
its degeneracy (measured by entropy in units of the Planck scale) is large. For
spherically symmetric black holes in 4 + d dimensions, both arguments again
lead to a mass threshold MC and degeneracy scale Mdeg of the order of the
fundamental scale of gravity MG. In the brane-world, deviations from the
Schwarzschild metric induced by bulk effects alter the horizon radius and
effective four-dimensional Euclidean action in such a way that MC \simeq Mdeg
might be either larger or smaller than MG. This opens up the possibility that
black holes exist with a mass smaller than MG and might be produced at the LHC
even if M>10 TeV, whereas effects due to bulk graviton exchanges remain
undetectable because suppressed by inverse powers of MG. Conversely, even if
black holes are not found at the LHC, it is still possible that MC>MG and MG
\simeq 1TeV.Comment: 4 pages, no figur
Widespread cell stress and mitochondrial dysfunction in early Alzheimer’s Disease
Cell stress and impaired oxidative phosphorylation are central to mechanisms of synaptic loss and neurodegeneration in the cellular pathology of Alzheimer’s disease (AD). We quantified the in vivo density of the endoplasmic reticulum stress marker, the sigma 1 receptor (S1R) using [11C]SA4503 PET, as well as that of mitochondrial complex I (MC1) with [18F]BCPP-EF and the pre-synaptic vesicular protein SV2A with [11C]UCB-J in 12 patients with early AD and in 16 cognitively normal controls. We integrated these molecular measures with assessments of regional brain volumes and brain perfusion (CBF) measured with MRI arterial spin labelling. 8 AD patients were followed longitudinally to estimate rates of change with disease progression over 12-18 months. The AD patients showed widespread increases in S1R (≤ 27%) and regional decreases in MC1 (≥ -28%), SV2A (≥ -25%), brain volume (≥ -23%), and CBF (≥ -26%). [18F]BCPP-EF PET MC1 density (≥ -12%) and brain volumes (≥ -5%) were further reduced at follow up in brain regions consistent with the differences between AD patients and controls at baseline. Exploratory analyses showing associations of MC1, SV2A and S1R density with cognitive changes at baseline and longitudinally with AD, but not in controls, suggested a loss of metabolic functional reserve with disease. Our study thus provides novel in vivo evidence for widespread cellular stress and bioenergetic abnormalities in early AD and that they may be clinically meaningful
Early and long-term morbidity after total laryngopharyngectomy
To determine the early and long-term morbidity of patients treated with a total laryngopharyngectomy and reconstruction using a jejunum interposition or gastric pull-up procedure. It is a retrospective study; and it is conducted in tertiairy referral center. Sixty-three patients were included in whom 70 reconstructions were performed (51 jejunum interpositions and 19 gastric pull-up procedures) between 1990 and 2007. The studied parameters were success rate of the reconstruction, early and long-term complication rate, and functional outcome including quality of life. Subjective quality of life analysis was determined by two questionnaires: the EORTC Quality of Life Questionnaire (QLQ)-C30 Dutch version 3.0, and the EORTC-Head and Neck (H & N 35). The success rates were 84 and 74%, respectively. The procedures were associated with a high complication rate (63% after jejunum interposition and 89% after gastric pull-up), and a lengthy rehabilitation. Surviving patients were found to have a good long-term quality of life. Complete oral intake was achieved in 97%, and speech rehabilitation in 95%. These procedures are associated with significant morbidity, high complication rates, lengthy rehabilitation, but a good long-term quality of life
The Hawking-Page crossover in noncommutative anti-deSitter space
We study the problem of a Schwarzschild-anti-deSitter black hole in a
noncommutative geometry framework, thought to be an effective description of
quantum-gravitational spacetime. As a first step we derive the noncommutative
geometry inspired Schwarzschild-anti-deSitter solution. After studying the
horizon structure, we find that the curvature singularity is smeared out by the
noncommutative fluctuations. On the thermodynamics side, we show that the black
hole temperature, instead of a divergent behavior at small scales, admits a
maximum value. This fact implies an extension of the Hawking-Page transition
into a van der Waals-like phase diagram, with a critical point at a critical
cosmological constant size in Plank units and a smooth crossover thereafter. We
speculate that, in the gauge-string dictionary, this corresponds to the
confinement "critical point" in number of colors at finite number of flavors, a
highly non-trivial parameter that can be determined through lattice
simulations.Comment: 24 pages, 6 figure, 1 table, version matching that published on JHE
Excluding Electroweak Baryogenesis in the MSSM
In the context of the MSSM the Light Stop Scenario (LSS) is the only region
of parameter space that allows for successful Electroweak Baryogenesis (EWBG).
This possibility is very phenomenologically attractive, since it allows for the
direct production of light stops and could be tested at the LHC. The ATLAS and
CMS experiments have recently supplied tantalizing hints for a Higgs boson with
a mass of ~ 125 GeV. This Higgs mass severely restricts the parameter space of
the LSS, and we discuss the specific predictions made for EWBG in the MSSM.
Combining data from all the available ATLAS and CMS Higgs searches reveals a
tension with the predictions of EWBG even at this early stage. This allows us
to exclude EWBG in the MSSM at greater than (90) 95% confidence level in the
(non-)decoupling limit, by examining correlations between different Higgs decay
channels. We also examine the exclusion without the assumption of a ~ 125 GeV
Higgs. The Higgs searches are still highly constraining, excluding the entire
EWBG parameter space at greater than 90% CL except for a small window of m_h ~
117 - 119 GeV.Comment: 24 Pages, 4 Figures (v3: fixed typos, minor corrections, added
references
A search for the decay modes B+/- to h+/- tau l
We present a search for the lepton flavor violating decay modes B+/- to h+/-
tau l (h= K,pi; l= e,mu) using the BaBar data sample, which corresponds to 472
million BBbar pairs. The search uses events where one B meson is fully
reconstructed in one of several hadronic final states. Using the momenta of the
reconstructed B, h, and l candidates, we are able to fully determine the tau
four-momentum. The resulting tau candidate mass is our main discriminant
against combinatorial background. We see no evidence for B+/- to h+/- tau l
decays and set a 90% confidence level upper limit on each branching fraction at
the level of a few times 10^-5.Comment: 15 pages, 7 figures, submitted to Phys. Rev.
- …