Wave reflection at a free interface in an anisotropic pyroelectric medium with nonclassical thermoelasticity

In this paper, the well-established two-dimensional mathematical model for linear pyroelectric materials is employed to investigate the reflection of waves at the boundary between a vacuum and an elastic, transversely isotropic, pyroelectric material. A comparative study between the solutions of (a) classical thermoelasticity, (b) Cattaneo–Lord–Shulman theory and (c) Green–Lindsay theory equations, characterised by none, one and two relaxation times, respectively, is presented. Suitable boundary conditions are considered in order to determine the reflection coefficients when incident elasto–electro–thermal waves impinge the free interface. It is established that, in the quasi-electrostatic approximation, three different classes of waves: (1) two principally elastic waves, namely a quasi-longitudinal Primary (qP) wave and a quasi-transverse Secondary (qS) wave; and (2) a mainly thermal (qT) wave. The observed electrical effects are, on the other hand, a direct consequence of mechanical and thermal phenomena due to pyroelectric coupling. The computed reflection coefficients of plane qP waves are found to depend upon the angle of incidence, the elastic, electric and thermal parameters of the medium, as well as the thermal relaxation times. The special cases of normal and grazing incidence are also derived and discussed. Finally, the reflection coefficients are computed for cadmium selenide observing the influence of (1) the anisotropy of the material, (2) the electrical potential and (3) temperature variations and (4) the thermal relaxation times on the reflection coefficients

Deformation patterns in a second-gradient lattice annular plate composed of "Spira mirabilis" fibers

In this paper, we aim to explore the mechanical potentialities of a material made of an orthogonal net of fibers arranged in logarithmic spirals. Therefore, an annular plate described with a second-gradient model is envisaged to evaluate the behavior of such material in a nonlinear elastic regime when large displacements and deformations occur. Several mechanical tests are performed numerically under the finite element method approximation obtained directly with a weak formulation based on the elastic energy that it is assumed to be predictive for this kind of network system of fibers. Plots reporting the mechanical characteristics in all the considered tests are provided to illustrate the overall mechanical behavior of the evaluated system

Ambulatory surgery for perianal Crohn’s disease. Study of feasibility

Background. One-third of Crohn’s disease (CD) patients present perianal fistula. The gold standard in the diagnosis and treatment of symptomatic perianal disease (PAD) in CD is the exploration of the anal canal and distal rectum under anesthesia (EUA). This procedure is mainly conducted as a day case surgery. Unfortunately, it is not always possible to proceed within the ideal timing and any delay may well represent a relevant clinical issue. The aim of this study was to evaluate the feasibility of outpatient treatment of symptomatic perianal fistulas in CD patients. Methods. All CD patients under regular follow-up at our inflammatory bowel disease referral center, presenting with symptomatic perianal fistulas, were offered surgical consultation. The data of patients were prospectively collected for three years (February 2014 to February 2017) for the purpose of the study. All clinical information, including previous EUA and/or records from MRI and endoscopic ultrasound, was included. Outpatient anal canal and distal rectum exploration and treatment (OE) were undertaken during the specialist surgical consultation. Fistulas were classified according to Parks’s classification; the type of outpatient treatment and compliance of patients were recorded. Pain was assessed by VAS at the time of the procedure and during the first control. Patients were followed up in the surgical clinic in relation to the study. Results. Ninety-two CD patients with symptomatic perianal fistulas had surgical consultation during the study period. OE was offered to all but 18 patients who fulfilled the exclusion criteria or had an extremely severe disease; six patients refused the OE (8.11%). Of the 68 patients undergoing OE, eleven (16.18%) had previous surgery for perianal disease. The OE was accomplished in sixty-one patients (89.71%), while in 7 patients, it was abandoned for scarce compliance. Nine patients (14.75%) underwent drainage of perianal abscess; in 3 of them, it was possible to probe the fistula tract, find the internal orifice, and pass a loose seton. Overall, setonage was performed in 50 patients (81.97%). Rectovaginal setons were placed in 3 patients and more than one seton (up to 3) in 6 cases. Fistulotomy was performed in 4 simple subcutaneous fistulous tracts. Concordance with the preoperative findings was found in 54 out of 61 patients. EUA was scheduled at the time of OE for the 7 patients who did not complete the procedure. All sixty-one patients who had the OE were followed up for a minimum of 12 months. Conclusions. This preliminary study indicates that OE in CD patients with symptomatic perianal fistulas is safe and feasible in a high-volume referral center. It might provide several benefits, including patients’ logistics, reduce or remove patients’ symptoms and discomfort, allow for a timely start of medical therapy, and avoid further complications

Interaction of glutathione transferase from horse erythrocytes with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole

7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole reacts with two thiol groups of the dimeric horse erythrocyte glutathione transferase at pH 5.0, with strong inactivation reversible on dithiothreitol treatment. The inactivation kinetic follows a biphasic pattern, similar to that caused by other thiol reagents as recently reported. Both S-methylglutathione and 1-chloro-2,4-dinitrobenzene protect the enzyme from inactivation. Analysis of the reactive SH group-containing peptide gives the sequence Ala-Ser-Cys-Leu-Tyr, identical with that of the peptide that contains the reactive cysteine 47 of the human placental transferase. In the presence of glutathione, the enzyme is not inactivated by this reagent, but it catalyzes its conjugation to glutathione. At higher pH values, 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole reacts with 2 tyrosines/dimer and lysines, as well as with cysteines. Reaction with lysine seems essentially without effect on activity; whether the reactive tyrosines are important for activity could not be determined using this reagent only. However, 2 tyrosines among the 4 that are nitrated by tetranitro-methane are important for activity

CAMBIOS EN LOS PROCESOS DE DISEÑO Y DESARROLLO DE PRODUCTOS: DESIGN THINKING, DISEÑO DE SERVICIOS Y EXPERIENCIA DEL USUARIO

This article addresses the new theories and concepts of design management: design thinking, user experience (UX) and service design. They consider people's experiences and focus on the characteristics of each one of them. From industrial design, the scope and relationships between these definitions - now better visible - were analyzed, which always belonged to the design field of the discipline, from which an attempt was made to identify how they influence innovation, design and development of new products. To account for the evolution that the design field has had, the most significant processes are contrasted to visualize the differences that make this change fundamental. Finally, it is concluded on its strategic relevance for the application in public and private organizations. Also taking into account how these theories are methodologically incorporated into the set of activities inherent to industrial design.Este artículo aborda las nuevas teorías y conceptos de la gestión del diseño: pensamiento de diseño, experiencia de usuario (UX) y diseño de servicios. Consideran las experiencias de las personas y se centran en las características de cada una de ellas. Desde el diseño industrial, se analizaron los alcances y relaciones entre estas definiciones -ahora más visibles-, que siempre pertenecieron al campo del diseño de la disciplina, desde el cual se intentó identificar cómo influyen en la innovación, diseño y desarrollo de nuevos productos. Para dar cuenta de la evolución que ha tenido el campo del diseño, se contrastan los procesos más significativos para visualizar las diferencias que hacen fundamental este cambio. Finalmente, se concluye sobre su relevancia estratégica para la aplicación en organismos públicos y privados. También teniendo en cuenta cómo estas teorías se incorporan metodológicamente al conjunto de actividades inherentes al diseño industrial

Temperature Regulation of Bacterial Production, Respiration, and Growth Efficiency in a Temperate Salt-marsh Estuary

There is consensus that temperature plays a major role in shaping microbial activity, but there are still questions as to how temperature influences different aspects of bacterioplankton carbon metabolism under different environmental conditions. We examined the temperature dependence of bacterioplankton carbon metabolism, whether this temperature dependence changes at different temperatures, and whether the relationship between temperature and carbon metabolism varies among estuarine sub-systems differing in their degree of enrichment. Two years of intensive sampling in a temperate estuary (Monie Bay, Chesapeake Bay, USA) revealed significant differences in the temperature dependence of bacterial production (BP) and respiration (BR), which drove a strong negative temperature response of bacterial growth efficiency (BGE). Accordingly, BGE was lower in summer (\u3c 0.2) and higher in winter (\u3e 0.5). For all measured metabolic processes, the most pronounced temperature response was observed at lower temperatures, with Q10 values generally 2-fold greater than in warmer waters. Despite significant differences in resource availability, both the temperature dependence and magnitude of BR and bacterioplankton carbon consumption (BCC) were remarkably similar among the 4 estuarine sub-systems. Although temperature dependencies of BP and BGE were also similar, their magnitude differed significantly, with highest values in the nutrient-enriched sub-system and lowest in the open bay. This pattern in carbon metabolism among sub- systems was present throughout the year and was confirmed by temperature manipulation experiments, suggesting the temperature effects on BP and BGE did not override the influence of resource availability. We conclude that temperature is the dominant factor regulating seasonality of BR and BCC in this system, whereas BP and BGE are influenced by both temperature and organic matter quality, with variation in the relative importance of each of these factors throughout the year

Large increases in carbon burial in northern lakes during the Anthropocene

Northern forests are important ecosystems for carbon (C) cycling and lakes within them process and bury large amounts of organic-C. Current burial estimates are poorly constrained and may discount other shifts in organic-C burial driven by global change. Here we analyse a suite of northern lakes to determine trends in organic-C burial throughout the Anthropocene. We found burial rates increased significantly over the last century and are up to five times greater than previous estimates. Despite a correlation with temperature, warming alone did not explain the increase in burial, suggesting the importance of other drivers including atmospherically deposited reactive nitrogen. Upscaling mean lake burial rates for each time period to global northern forests yields up to 4.5 Pg C accumulated in the last 100 years—20% of the total burial over the Holocene. Our results indicate that lakes will become increasingly important for C burial under future global change scenarios