Sensitivity Study of the Reactive Transport Model for CO2 Injection into the Utsira Saline Formation Using 3D Fluid Flow Model History Matched with 4D Seismic

AbstractThis article reports on the reactive transport simulation work dealing with CO2 storage at Sleipner. The study has been initiated in the CO2ReMoVe European project with one preliminary scenario and is carrying on in the CO2CARE one with a sensibility study. Its main purpose was to simulate on the long term the CO2 fate and to estimate the proportion of trapped CO2 per trapping mechanisms over time. All the simulations were performed using a 2D reactive transport model based on a 3D fluid flow model history matched with 4D seismic

In Salah CO2 injection modeling: A preliminary approach to predict short term reservoir behavior

AbstractA short term performance assessment methodology under development and validation at the In Salah CO2 storage site is presented. The progressive approach first concludes of the necessity to consider a dual media reservoir system at Krechba to fit with gas reservoir production, CO2 injection and CO2 breakthrough at an old appraisal well (Kb-5). To improve gas migration prediction while also considering the geomechanical behavior of the site, an extended geomodel has been developed. Fluid pressure simulation results representative of the dual media reservoir model and of the simple medium upper layer ones (up to the water table) are used to initiate the geomechanical modeling. Comparison of the preliminary geomechanical simulation results assuming a poro-elastic behavior and InSAR satellite surface displacement data are coherent and in the same order of magnitude (∼20 millimeters at maximum displacement)

Deltaic and Coastal Sediments as Recorders of Mediterranean Regional Climate and Human Impact Over the Past Three Millennia

International audienc

Contribution à la valorisation d'un vaccin anti-clostridien chez le porcelet

Les porcelets nouveau-nés sont sensibles à de nombreuses affections, dont les affections digestives à clostridies. La principale clostridiose rencontrée chez le porcelet sous la mère est l'entérite à Clostridium perfringens de type AB2, qui est responsable de diarrhées sévères dès les premiers jours de vie. Elle entraîne également des retards de croissance et peut provoquer jusqu'à 30 % de mortalité. La seule solution permettant de lutter efficacement contre l'entérite à C. perfringens de type AB2 est la vaccination des truies gestantes avec un vaccin anti-clostridien, tel que nous le démontrons dans notre essai. L'emploi d'anti-infectieux, l'hygiène des locaux et des truies sont des mesures complémentaires à ne pas négliger.NANTES-Ecole Nat.Vétérinaire (441092302) / SudocSudocFranceF

SGLT2 Inhibitors and Potential Applications in Treating Metabolic Syndrome

SGLT2 inhibitors act to induce glucosuria and have been shown to be efficacious in the treatment of type II diabetes mellitus but have also been shown to positively affect cardiovascular conditions and some benefitting kidney function. SGLT2i have shown to be effective in more advanced conditions but may eventually be a treatment in more general metabolic dysfunction. Metabolic syndrome is a clinical diagnosis for establishing risk for ischemic heart disease and diabetes. The prevalence of type II diabetes mellitus, heart disease, and severe vascular events steadily increased over recent decades. In addition to the established benefits of diet and exercise, SGLT2 inhibitor therapy may be able to aid in the treatment of metabolic syndrome from its proven cardiovascular and anti-hyperglycemic benefits. Pharmacologic modeling in canines is also considered, as they present with similar diagnoses and offer a model that shares many of the characteristics of humans in metabolic dysfunction.This is a pre-print of the article Goddard, Clayton, Karin Allenspach, Audrey Deflandre, Claudine Zemirline, Emilie Guillot, and Jonathan P. Mochel. "SGLT2 Inhibitors and Potential Applications in Treating Metabolic Syndrome." (2022). DOI:10.20944/preprints202204.0202.v1. Attribution 4.0 International (CC BY 4.0). Copyright 2022 The Authors. Posted with permission

Repellent and insecticidal efficacy of a combination of dinotefuran, pyriproxyfen and permethrin (Vectra® 3D) against Culex pipiens in dogs

Culex pipiens is an important vector of pathogens of substantial medical and veterinary importance such as Dirofilaria immitis and Dirofilaria repens or the West Nile Virus. The control of these mosquitoes is therefore essential to control the transmission of mosquito-borne agents to humans and animals. A combination of dinotefuran, permethrin and pyriproxyfen (Vectra® 3D) has already shown its efficacy against Aedes aegypti. The aim of this study was to confirm the efficacy of this combination in repelling and killing another species of mosquito, Culex pipiens, after a single topical application to dogs. Twelve adult Beagle dogs with an equal receptivity to mosquitoes were included in the study and divided in two groups of six dogs: an untreated control group and a group treated with a combination containing 54 mg/mL dinotefuran +4.84 mg/mL pyriproxyfen +397 mg/mL permethrin (Vectra® 3D). All dogs were challenged with 80 Culex pipiens females for 90 ± 5 min on Days - 28, 1, 7, 14, 21 and 28. The treatment was applied once topically on Day 0. Count and engorgement determination of dead and live mosquitoes were performed after each exposure to treated and untreated dogs. Compared to control dogs, the spot-on formulation provided a repellent efficacy (anti-feeding effect) against mosquitoes of 98.9%, 98.8%, 98.6%, 96.7% and 97.9% on Days 1, 7, 14, 21 and 28 respectively. There was a significant difference (p ≤ 0.05) between the treated and controlled groups on every assessment day. The insecticidal efficacy on treated dogs at 90 min was 34.7%, 50.3%, 39.7%, 22.8% and 11.4% on Days 1, 7, 14, 21 and 28 respectively. There was a significant difference between the treated and controlled groups for live mosquitoes for all assessment days (p < 0.05). A single topical application of a combination of dinotefuran, permethrin and pyriproxyfen showed a significant repellent effect (i.e. >96%) against Culex pipiens which lasted for 28 days. The results suggest that the Vectra® 3D spot-on solution could be used as an effective mosquito control strategy in dogs and is therefore recommended for use in a dirofilariosis prevention programme

Influence of the organic matter composition on benthic oxygen demand in the Rhône River prodelta (NW Mediterranean Sea)

International audienc