Evaluation of a novel precision template-guided biopsy system for detecting prostate cancer

To explore the ability of a novel transrectal ultrasonography (TRUS) device (TargetScan TM , Envisioneering Medical Technologies, St. Louis MO) that creates a three-dimensional map of the prostate and calculates an optimal biopsy scheme, to accurately sample the prostate and define the true extent of disease, as standard TRUS-guided prostate biopsy relies on the operator to distribute the biopsy sites, often resulting in under- and oversampling regions of the gland. PATIENTS AND METHODS In a multicentre retrospective chart review evaluating patients who had a TargetScan prostate biopsy between January 2006 and June 2007, we determined the overall cancer detection rate in all patients and in subgroups based on prostate specific antigen level, digital rectal examination, and indication for biopsy. We assessed the pathological significance of cancer detected, defined as a Gleason score of ≥7, positive margins, extracapsular disease or >20% tumour volume in the prostatectomy specimen. We also evaluated the concordance in Gleason score between the biopsy and prostatectomy specimen. RESULTS Cancer was detected in 50 (35.7%) of the 140 patients biopsied, including 39 (47.6%) with no previous biopsies. Of 23 prostatectomy specimens, 20 (87%) had pathologically significant disease. The biopsy predicted the prostatectomy Gleason score in 12 patients (52%), overestimated in two (9%), underestimated in eight (35%), and biopsy Gleason score could not be assigned in one (4%). CONCLUSIONS Template-guided biopsy potentially produces a higher cancer detection rate and more accurate assessment of grade. Prostatectomy specimens did not have a high rate of pathologically insignificant disease.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73501/1/j.1464-410X.2008.07832.x.pd

Developing a sustainable career through discourse: a qualitative study on a group of Italian project managers

Purpose: The current study makes two main contributions: one theoretical and one methodological. First, it investigated the theoretical prepositions of career sustainability perspective, which appears particularly suitable for examining project managers' careers' dynamics and patterns, featured by explicit and recursive interactions between individual, temporal and contextual factors. Second, the study aimed to adopt a qualitative approach to this topic as to allow a deeper understanding of individual narratives about careers, highlighting underexplored issues and peculiarities that future research could further examine through quantitative methodologies. Design/methodology/approach: Project managers' careers are still an under-researched topic, especially through qualitative methods. The study applied career sustainability theory to the realm of project management, moreover, adopting a socio-constructivist perspective. Participants were 50 Italian project managers who were involved through a narrative in-depth interview that focused on career and career success. Their answers were analyzed through thematic analysis of contents and diatextual analysis. Findings: Results showed that project managers' career could be a prototypical example of sustainable career, basically described in terms of four basic constitutive dimensions as follows: time frame, social space, agency and meaning. Implications for both future theoretical expansion of career sustainability theory and project managers' career management interventions were also discussed. Originality/value: The originality of the paper could be found in the effort to adopt a socio-constructivist perspective to investigate the topic of career sustainability taking the exemplary case of project managers' career

Cloud2FEM: A finite element mesh generator based on point clouds of existing/historical structures

Nowadays, the common output of surveying activities on existing/historical structures consists of dense point clouds. However, the direct and automatic exploitation of point clouds for structural purposes, i.e. to generate finite element models, is still very limited. In this framework, the Cloud2FEM software supplies an automatic finite element mesh generator based on point clouds of existing/historical structures. Cloud2FEM is based on open-source Python libraries with graphical interface. The point cloud is initially sliced along with the vertical direction. Then, closed polygons are recognized on each slice and stacked vertically thanks to the use of voxels. The voxelized volume is exported into 3D solid hexahedron-based finite element meshes. Suitable graphical tools are developed to help the user adjusting local potential criticalities in the slices, also when partial information is missing in the points cloud. An illustrative example is given to highlight the Cloud2FEM potentialities

Human resource management practices perception and career success: The mediating roles of employability and extra-role behaviors

Over the last decades, growing interest has been devoted to employees’ perceptions of Human Resource Management Practices because of their positive influence on individual attitudes and behaviors as well as on organizational performance. Furthermore, assuming the mutual benefits coming from a people-based management of the human capital in organizations, both in terms of employees’ increased motivation, engagement and commitment, and consequently enhanced performance and competitive advantage, recent research in the field concentrated on the impact of HRM practices perceptions on some distinctive individual attitudes and behaviors driving the success of organizations especially in times of radical change like the present ones. Moving from these assumptions, the aim of the present study was to examine the relationship between HRM practices perception and objective career success, considering the mediating role played by employability and extra-role behaviors. Participants were 960 Italian employees who filled an online self-report questionnaire available through the web platform Google Forms. The questionnaire encompassed socio-demographic information and self-report scales assessing the study variables. Results showed that HRM practices perception was positively related to employability, objective career success, and extra-role behaviors. Implications for theory and practice, limitations, and future research directions were also discussed

Proactive, boundaryless, and confident graduates entering the labour market: does need for cognitive closure play a role as a moderator?

The university to work transition is a crucial and delicate stage for graduates, as it involves an essential change of role. Previous studies have shown that proactive personality, boundaryless mind-set and career self-efficacy are critical variables for a successful labour market integration/entry. This study analyzes the involvement of the need for cognitive closure as an individual variable that can both favor and hinder this process. Specifically, this work examines the moderating role of need for cognitive closure in the indirect association between proactive personality and career self-efficacy through boundaryless mind-set in a sample of 762 adults enrolled at the university or recently graduated therein. Results showed that career self-efficacy was positively predicted by proactive personality and boundaryless mind-set. Although a significant indirect effect was present thus confirming our first hypothesis, it did not vary depending on the need for cognitive closure proving that need for cognitive closure did not act as a moderator of this indirect association, hence not supporting our second hypothesis. These findings were discussed concerning the complexity of students’ choices in transition and the nature of the information processing process needed for those choices

Quantifying the effect of demixing approaches on directed connectivity estimated between reconstructed EEG sources

Electrical activity recorded on the scalp using electroencephalography (EEG) results from the mixing of signals originating from different regions of the brain as well as from artifactual sources. In order to investigate the role of distinct brain areas in a given experiment, the signal recorded on the sensors is typically projected back into the brain (source reconstruction) using algorithms that address the so-called EEG inverse problem. Once the activity of sources located inside of the brain has been reconstructed, it is often desirable to study the statistical dependencies among them, in particular to quantify directional dynamical interactions between brain areas. Unfortunately, even when performing source reconstruction, the superposition of signals that is due to the propagation of activity from sources to sensors cannot be completely undone, resulting in potentially biased estimates of directional functional connectivity. Here we perform a set of simulations involving interacting sources to quantify source connectivity estimation performance as a function of the location of the sources, their distance to each other, the noise level, the source reconstruction algorithm, and the connectivity estimator. The generated source activity was projected onto the scalp and projected back to the cortical level using two source reconstruction algorithms, linearly constrained minimum variance beamforming and Exact' low-resolution tomography (eLORETA). In source space, directed connectivity was estimated using multi-variate Granger causality and time-reversed Granger causality, and compared with the imposed ground truth. Our results demonstrate that all considered factors significantly affect the connectivity estimation performance