5,466 research outputs found
Connectionist Temporal Modeling for Weakly Supervised Action Labeling
We propose a weakly-supervised framework for action labeling in video, where
only the order of occurring actions is required during training time. The key
challenge is that the per-frame alignments between the input (video) and label
(action) sequences are unknown during training. We address this by introducing
the Extended Connectionist Temporal Classification (ECTC) framework to
efficiently evaluate all possible alignments via dynamic programming and
explicitly enforce their consistency with frame-to-frame visual similarities.
This protects the model from distractions of visually inconsistent or
degenerated alignments without the need of temporal supervision. We further
extend our framework to the semi-supervised case when a few frames are sparsely
annotated in a video. With less than 1% of labeled frames per video, our method
is able to outperform existing semi-supervised approaches and achieve
comparable performance to that of fully supervised approaches.Comment: To appear in ECCV 201
A possible role for selenoprotein glutathione peroxidase (GPx1) and thioredoxin reductases (TrxR1) in thyroid cancer. Our experience in thyroid surgery
Abstract
Background: Oxidative stress is responsible for some alterations in the chemical structure and, consequently, in
the function of proteins, lipids, and DNA. Recent studies have linked oxidative stress to cancers, particularly thyroid
cancer, but the mechanisms remain unclear. Here, we further characterize the role of oxidative stress in thyroid cancer
by analyzing the expression of two selenium antioxidant molecules, glutathione peroxidase (GPx1) and thioredoxin
reductase (TrxR1) in thyroid cancer cells.
Methods: Samples of both healthy thyroid tissue and thyroid tumor were taken for analysis after total thyroidectomy.
The expression of GPx1 and TrxR1 was revealed by Western blot analysis and quantified by densitometric analyses,
while the evaluation of free radicals was performed by Electron Paramagnetic Resonance (EPR)-spin trapping
technique.
Results: Our results show a decrease in the expression of GPx1 and TrxR1 (− 45.7 and − 43.2% respectively, p < 0.01)
in the thyroid cancer cells compared to the healthy cells. In addition, the EPR technique shows an increase of free
radicals in tumor tissue, significantly higher than that found in healthy thyroid tissue (+ 116.3%, p < 0.01).
Conclusions: Our findings underscore the relationship between thyroid cancer and oxidative stress, showing the
imbalance of the oxidant/antioxidant system in thyroid cancer tissue. These results suggest that either the inability to
produce adequate antioxidant defense or an increased consumption of antioxidants, due to the hyper-production of
free radicals, may play a crucial role in thyroid cancer.
Keywords: Oxidative stress, Thyroid cancer, Glutathione peroxidase (GPx1), Thioredoxin reductases (TrxR1), Selenium
enzyme
Automated Morphological Classification of SDSS Red Sequence Galaxies
(abridged) In the last decade, the advent of enormous galaxy surveys has
motivated the development of automated morphological classification schemes to
deal with large data volumes. Existing automated schemes can successfully
distinguish between early and late type galaxies and identify merger
candidates, but are inadequate for studying detailed morphologies of red
sequence galaxies. To fill this need, we present a new automated classification
scheme that focuses on making finer distinctions between early types roughly
corresponding to Hubble types E, S0, and Sa. We visually classify a sample of
984 non-starforming SDSS galaxies with apparent sizes >14". We then develop an
automated method to closely reproduce the visual classifications, which both
provides a check on the visual results and makes it possible to extend
morphological analysis to much larger samples. We visually classify the
galaxies into three bulge classes (BC) by the shape of the light profile in the
outer regions: discs have sharp edges and bulges do not, while some galaxies
are intermediate. We separately identify galaxies with features: spiral arms,
bars, clumps, rings, and dust. We find general agreement between BC and the
bulge fraction B/T measured by the galaxy modeling package GIM2D, but many
visual discs have B/T>0.5. Three additional automated parameters -- smoothness,
axis ratio, and concentration -- can identify many of these high-B/T discs to
yield automated classifications that agree ~70% with the visual classifications
(>90% within one BC). Both methods are used to study the bulge vs. disc
frequency as a function of four measures of galaxy 'size': luminosity, stellar
mass, velocity dispersion, and radius. All size indicators show a fall in disc
fraction and a rise in bulge fraction among larger galaxies.Comment: 24 pages, 20 figures, MNRAS accepte
Value-aware Importance Weighting for Off-policy Reinforcement Learning
Importance sampling is a central idea underlying off-policy prediction in
reinforcement learning. It provides a strategy for re-weighting samples from a
distribution to obtain unbiased estimates under another distribution. However,
importance sampling weights tend to exhibit extreme variance, often leading to
stability issues in practice. In this work, we consider a broader class of
importance weights to correct samples in off-policy learning. We propose the
use of which take into account the
sample space to provide lower variance, but still unbiased, estimates under a
target distribution. We derive how such weights can be computed, and detail key
properties of the resulting importance weights. We then extend several
reinforcement learning prediction algorithms to the off-policy setting with
these weights, and evaluate them empirically.Comment: CoLLAs 202
Computational Methods for UV-Suppressed Fermions
Lattice fermions with suppressed high momentum modes solve the ultraviolet
slowing down problem in lattice QCD. This paper describes a stochastic
evaluation of the effective action of such fermions. The method is a based on
the Lanczos algorithm and it is shown to have the same complexity as in the
case of standard fermions.Comment: 10 pages, 1 figur
Measuring Ages and Elemental Abundances from Unresolved Stellar Populations: Fe, Mg, C, N, and Ca
We present a method for determining mean light-weighted ages and abundances
of Fe, Mg, C, N, and Ca, from medium resolution spectroscopy of unresolved
stellar populations. The method, pioneered by Schiavon (2007), is implemented
in a publicly available code called EZ_Ages. The method and error estimation
are described, and the results tested for accuracy and consistency, by
application to integrated spectra of well-known Galactic globular and open
clusters. Ages and abundances from integrated light analysis agree with studies
of resolved stars to within +/-0.1 dex for most clusters, and to within +/-0.2
dex for nearly all cases. The results are robust to the choice of Lick indices
used in the fitting to within +/-0.1 dex, except for a few systematic
deviations which are clearly categorized. The realism of our error estimates is
checked through comparison with detailed Monte Carlo simulations. Finally, we
apply EZ_Ages to the sample of galaxies presented in Thomas et al. (2005) and
compare our derived values of age, [Fe/H], and [alpha/Fe] to their analysis. We
find that [alpha/Fe] is very consistent between the two analyses, that ages are
consistent for old (Age > 10 Gyr) populations, but show modest systematic
differences at younger ages, and that [Fe/H] is fairly consistent, with small
systematic differences related to the age systematics. Overall, EZ_Ages
provides accurate estimates of fundamental parameters from medium resolution
spectra of unresolved stellar populations in the old and intermediate-age
regime, for the first time allowing quantitative estimates of the abundances of
C, N, and Ca in these unresolved systems. The EZ_Ages code can be downloaded at
http://www.ucolick.org/~graves/EZ_Ages.htmlComment: Accepted to ApJ
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