Non-Associativity in the Clifford Bundle on the Parallelizable Torsion 7-Sphere

In this paper we discuss generalized properties of non-associativity in Clifford bundles on the 7-sphere S7. Novel and prominent properties inherited from the non-associative structure of the Clifford bundle on S7 are demonstrated. They naturally lead to general transformations of the spinor fields on S7 and have dramatic consequences for the associated Kac-Moody current algebras. All additional properties concerning the non-associative structure in the Clifford bundle on S7 are considered. We further discuss and explore their applications.Comment: 16 page

Baryon Number-Induced Chern-Simons Couplings of Vector and Axial-Vector Mesons in Holographic QCD

We show that holographic models of QCD predict the presence of a Chern-Simons coupling between vector and axial-vector mesons at finite baryon density. In the AdS/CFT dictionary, the coefficient of this coupling is proportional to the baryon number density, and is fixed uniquely in the five-dimensional holographic dual by anomalies in the flavor currents. For the lightest mesons, the coupling mixes transverse $\rho$ and $a_1$ polarization states. At sufficiently large baryon number densities, it produces an instability, which causes the $\rho$ and $a_1$ mesons to condense in a state breaking both rotational and translational invariance.Comment: 4 page

Anomaly mediated neutrino-photon interactions at finite baryon density

We propose new physical processes based on the axial vector anomaly and described by the Wess-Zumino-Witten term that couples the photon, Z-boson, and the omega-meson. The interaction takes the form of a pseudo-Chern-Simons term, $\sim \epsilon_{\mu\nu\rho\sigma}\omega^\mu Z^\nu F^{\rho\sigma}$. This term induces neutrino-photon interactions at finite baryon density via the coupling of the Z-boson to neutrinos. These interactions may be detectable in various laboratory and astrophysical arenas. The new interactions may account for the MiniBooNE excess. They also produce a competitive contribution to neutron star cooling at temperatures >10^9 K. These processes and related axion--photon interactions at finite baryon density appear to be relevant in many astrophysical regimes.Comment: 4 pages, 2 figures; references adde

Risk Adjustment In Neurocritical care (RAIN)--prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study.

OBJECTIVES: To validate risk prediction models for acute traumatic brain injury (TBI) and to use the best model to evaluate the optimum location and comparative costs of neurocritical care in the NHS. DESIGN: Cohort study. SETTING: Sixty-seven adult critical care units. PARTICIPANTS: Adult patients admitted to critical care following actual/suspected TBI with a Glasgow Coma Scale (GCS) score of < 15. INTERVENTIONS: Critical care delivered in a dedicated neurocritical care unit, a combined neuro/general critical care unit within a neuroscience centre or a general critical care unit outside a neuroscience centre. MAIN OUTCOME MEASURES: Mortality, Glasgow Outcome Scale - Extended (GOSE) questionnaire and European Quality of Life-5 Dimensions, 3-level version (EQ-5D-3L) questionnaire at 6 months following TBI. RESULTS: The final Risk Adjustment In Neurocritical care (RAIN) study data set contained 3626 admissions. After exclusions, 3210 patients with acute TBI were included. Overall follow-up rate at 6 months was 81%. Of 3210 patients, 101 (3.1%) had no GCS score recorded and 134 (4.2%) had a last pre-sedation GCS score of 15, resulting in 2975 patients for analysis. The most common causes of TBI were road traffic accidents (RTAs) (33%), falls (47%) and assault (12%). Patients were predominantly young (mean age 45 years overall) and male (76% overall). Six-month mortality was 22% for RTAs, 32% for falls and 17% for assault. Of survivors at 6 months with a known GOSE category, 44% had severe disability, 30% moderate disability and 26% made a good recovery. Overall, 61% of patients with known outcome had an unfavourable outcome (death or severe disability) at 6 months. Between 35% and 70% of survivors reported problems across the five domains of the EQ-5D-3L. Of the 10 risk models selected for validation, the best discrimination overall was from the International Mission for Prognosis and Analysis of Clinical Trials in TBI Lab model (IMPACT) (c-index 0.779 for mortality, 0.713 for unfavourable outcome). The model was well calibrated for 6-month mortality but substantially underpredicted the risk of unfavourable outcome at 6 months. Baseline patient characteristics were similar between dedicated neurocritical care units and combined neuro/general critical care units. In lifetime cost-effectiveness analysis, dedicated neurocritical care units had higher mean lifetime quality-adjusted life-years (QALYs) at small additional mean costs with an incremental cost-effectiveness ratio (ICER) of £14,000 per QALY and incremental net monetary benefit (INB) of £17,000. The cost-effectiveness acceptability curve suggested that the probability that dedicated compared with combined neurocritical care units are cost-effective is around 60%. There were substantial differences in case mix between the 'early' (within 18 hours of presentation) and 'no or late' (after 24 hours) transfer groups. After adjustment, the 'early' transfer group reported higher lifetime QALYs at an additional cost with an ICER of £11,000 and INB of £17,000. CONCLUSIONS: The risk models demonstrated sufficient statistical performance to support their use in research but fell below the level required to guide individual patient decision-making. The results suggest that management in a dedicated neurocritical care unit may be cost-effective compared with a combined neuro/general critical care unit (although there is considerable statistical uncertainty) and support current recommendations that all patients with severe TBI would benefit from transfer to a neurosciences centre, regardless of the need for surgery. We recommend further research to improve risk prediction models; consider alternative approaches for handling unobserved confounding; better understand long-term outcomes and alternative pathways of care; and explore equity of access to postcritical care support for patients following acute TBI. FUNDING: The National Institute for Health Research Health Technology Assessment programme

Revisiting Clifford algebras and spinors III: conformal structures and twistors in the paravector model of spacetime

This paper is the third of a series of three, and it is the continuation of math-ph/0412074 and math-ph/0412075. After reviewing the conformal spacetime structure, conformal maps are described in Minkowski spacetime as the twisted adjoint representation of the group Spin_+(2,4), acting on paravectors. Twistors are then presented via the paravector model of Clifford algebras and related to conformal maps in the Clifford algebra over the lorentzian R{4,1}$ spacetime. We construct twistors in Minkowski spacetime as algebraic spinors associated with the Dirac-Clifford algebra Cl(1,3)(C) using one lower spacetime dimension than standard Clifford algebra formulations, since for this purpose the Clifford algebra over R{4,1} is also used to describe conformal maps, instead of R{2,4}. Although some papers have already described twistors using the algebra Cl(1,3)(C), isomorphic to Cl(4,1), the present formulation sheds some new light on the use of the paravector model and generalizations.Comment: 17 page

Chemerin receptor blockade improves vascular function in diabetic obese mice via redox-sensitive- and Akt-dependent pathways

Chemerin and its G protein-coupled receptor [chemerin receptor 23 (ChemR23)] have been associated with endothelial dysfunction, inflammation, and insulin resistance. However, the role of chemerin on insulin signaling in the vasculature is still unknown. We aimed to determine whether chemerin reduces vascular insulin signaling and whether there is interplay between chemerin/ChemR23, insulin resistance, and vascular complications associated with type 2 diabetes (T2D). Molecular and vascular mechanisms were probed in mesenteric arteries and cultured vascular smooth muscle cells (VSMCs) from C57BL/6J, nondiabetic lean db/m, and diabetic obese db/db mice as well as in human microvascular endothelial cells (HMECs). Chemerin decreased insulin-induced vasodilatation in C57BL/6J mice, an effect prevented by CCX832 (ChemR23 antagonist) treatment. In VSMCs, chemerin, via oxidative stress- and ChemR23-dependent mechanisms, decreased insulin-induced Akt phosphorylation, glucose transporter 4 translocation to the membrane, and glucose uptake. In HMECs, chemerin decreased insulin-activated nitric oxide signaling. AMP-activated protein kinase phosphorylation was reduced by chemerin in both HMECs and VSMCs. CCX832 treatment of db/db mice decreased body weight, insulin, and glucose levels as well as vascular oxidative stress. CCX832 also partially restored vascular insulin responses in db/db and high-fat diet-fed mice. Our novel in vivo findings highlight chemerin/ChemR23 as a promising therapeutic target to limit insulin resistance and vascular complications associated with obesity-related diabetes

Mass and luminosity evolution of young stellar objects

A model of protostar mass and luminosity evolution in clusters gives new estimates of cluster age, protostar birthrate, accretion rate and mean accretion time. The model assumes constant protostar birthrate, core-clump accretion, and equally likely accretion stopping. Its parameters are set to reproduce the initial mass function, and to match protostar luminosity distributions in nearby star-forming regions. It obtains cluster ages and birthrates from the observed numbers of protostars and pre-main sequence (PMS) stars, and from the modal value of the protostar luminosity. In 31 embedded clusters and complexes the global cluster age is 1-3 Myr, matching available estimates based on optical spectroscopy and evolutionary tracks. This method of age estimation is simpler than optical spectroscopy, and is more useful for young embedded clusters where optical spectrocopy is not possible. In the youngest clusters, the protostar fraction decreases outward from the densest gas, indicating that the local star-forming age increases outward from a few 0.1 Myr in small protostar-dominated zones to a few Myr in large PMS-dominated zones.Comment: To appear in The Astrophysical Journal, Part

Ultrafast electron microscopy for probing magnetic dynamics

The spatial features of ultrafast changes in magnetic textures carry detailed information on microscopic couplings and energy transport mechanisms. Electrons excel in imaging such picosecond or shorter processes at nanometer length scales. We review the range of physical interactions that produce ultrafast magnetic contrast with electrons, and specifically highlight the recent emergence of ultrafast Lorentz transmission electron microscopy. From the fundamental processes involved in demagnetization at extremely short timescales to skyrmion-based devices, we show that ultrafast electron imaging will be a vital tool in solving pressing problems in magnetism and magnetic materials where nanoscale inhomogeneity, microscopic field measurement, non-equilibrium behavior or dynamics are involved

A POLÍTICA DE COTAS NA AMÉRICA LATINA COMO IMPULSORA DA REPRESENTAÇÃO FEMININA NA CÂMARA BAIXA

Nos anos 1990, a pressão externa da comunidade internacional, combinada com a pressão interna dos movimentos feministas, gerou ambiente propício para a reflexão de políticas públicas sobre igualdade de gênero em diversos países latino-americanos. Neste contexto, foi gestada a política de cotas legislativas para inclusão de mulheres na política institucional na região. A política de cotas, que teve início na Argentina de 1991, foi implementada nos anos que se seguiram em mais 14 países. É nesse sentido, e a partir de literatura atinente, que o presente trabalho expõe os processos em torno do surgimento de cotas legislativas; assim como seus principais resultados e desafios na mencionada região. A relevância desta empreitada reside na necessidade por um diagnóstico atualizado sobre cotas, em nível regional. Ainda que haja vasta literatura sobre o tema, em sua maioria, versam sobre experiências nacionais. Os resultados encontrados no decorrer deste trabalho apontam que, de modo geral, a representação feminina cresceu nos parlamentos da região. No entanto, aponta também a discrepância de intensidade entre cada país, assim como a predominância de sucesso em democracias que contam com mandatos de posição, magnitude em distrito eleitoral maior e listas fechadas e bloqueada