Modelling of JET hybrid scenarios with GLF23 transport model: E × B shear stabilization of anomalous transport

The E&nbsp;×&nbsp;B shear stabilization of anomalous transport in JET hybrid discharges is studied via self-consistent predictive modelling of electron and ion temperature, ion density and toroidal rotation velocity performed with the GLF23 model. The E&nbsp;×&nbsp;B shear stabilization factor (parameter α E in the GLF23 model) is adjusted to predict accurately the four simulated quantities under different experimental conditions, and the uncertainty in α E determined by 15% deviation between simulated and measured quantities is estimated. A correlation of α E with toroidal rotation velocity and E&nbsp;×&nbsp;B shearing rate is found in the low density plasmas, suggesting that the turbulence quench rule may be more complicated than assumed in the GLF23 model with constant α E . For the selected discharges the best predictive accuracy is obtained by using weak/no E&nbsp;×&nbsp;B shear stabilization (i.e. α E&nbsp;≈&nbsp;0) at low toroidal angular frequency (Ω&nbsp;&lt;&nbsp;60&nbsp;krad&nbsp;s −1 ), even in the scenarios with the current overshoot, and α E&nbsp;=&nbsp;0.9 at high frequency (Ω&nbsp;&gt;&nbsp;100&nbsp;krad&nbsp;s −1 ). Interestingly, a weak E&nbsp;×&nbsp; B shear stabilization of anomalous transport is found in the medium density strongly rotating discharge. An importance of linear β e stabilization in this discharge is estimated and compared to the low density discharge with equally high β e . The toroidal rotation velocity is well predicted here by assuming that the momentum diffusion coefficient is a fraction of thermal ion diffusivity. Taking into account the α E and Prandtl number with their uncertainties determined in the modelling of JET hybrid discharges, the performance of ITER hybrid scenario with optimized heat mix (33&nbsp;MW of NBI and 20&nbsp;MW of ECCD) is estimated showing the importance of toroidal rotation for achieving Q &nbsp;&gt;&nbsp;5.</p

Italian guidelines for primary headaches: 2012 revised version

The first edition of the Italian diagnostic and therapeutic guidelines for primary headaches in adults was published in J Headache Pain 2(Suppl. 1):105–190 (2001). Ten years later, the guideline committee of the Italian Society for the Study of Headaches (SISC) decided it was time to update therapeutic guidelines. A literature search was carried out on Medline database, and all articles on primary headache treatments in English, German, French and Italian published from February 2001 to December 2011 were taken into account. Only randomized controlled trials (RCT) and meta-analyses were analysed for each drug. If RCT were lacking, open studies and case series were also examined. According to the previous edition, four levels of recommendation were defined on the basis of levels of evidence, scientific strength of evidence and clinical effectiveness. Recommendations for symptomatic and prophylactic treatment of migraine and cluster headache were therefore revised with respect to previous 2001 guidelines and a section was dedicated to non-pharmacological treatment. This article reports a summary of the revised version published in extenso in an Italian version

Repurposing NGO data for better research outcomes: A scoping review of the use and secondary analysis of NGO data in health policy and systems research

Background Non-government organisations (NGOs) collect and generate vast amounts of potentially rich data, most of which are not used for research purposes. Secondary analysis of NGO data (their use and analysis in a study for which they were not originally collected) presents an important but largely unrealised opportunity to provide new research insights in critical areas including the evaluation of health policy and programmes. Methods A scoping review of the published literature was performed to identify the extent to which secondary analysis of NGO data has been used in health policy and systems research (HPSR). A tiered analytic approach provided a comprehensive overview and descriptive analyses of the studies which: 1) used data produced or collected by or about NGOs; 2) performed secondary analysis of the NGO data (beyond use of an NGO report as a supporting reference); 3) used NGO-collected clinical data. Results Of the 156 studies which performed secondary analysis of NGO-produced or collected data, 64% (n=100) used NGO-produced reports (e.g. to critique NGO activities and as a contextual reference) and 8% (n=13) analysed NGO-collected clinical data.. Of the studies, 55% investigated service delivery research topics, with 48% undertaken in developing countries and 17% in both developing and developed. NGO-collected clinical data enabled HPSR within marginalised groups (e.g. migrants, people in conflict-affected areas), with some limitations such as inconsistencies and missing data. Conclusion We found evidence that NGO-collected and produced data are most commonly perceived as a source of supporting evidence for HPSR and not as primary source data. However, these data can facilitate research in under-researched marginalised groups and in contexts that are hard to reach by academics, such as conflict-affected areas. NGO–academic collaboration could help address issues of NGO data quality to facilitate their more widespread use in research. Their use could enable relevant and timely research in the areas of health policy, programme evaluation and advocacy to improve health and reduce health inequalities, especially in marginalised groups and developing countries

Nebulisation of synthetic lamellar lipids mitigates radiation-induced lung injury in a large animal model

Item originally deposited in University of Edinburgh, Edinburgh Research Explorer Repository at: https://www.research.ed.ac.uk/portal/en/publications/nebulisation-of-synthetic-lamellar-lipids-mitigates-radiationinduced-lung-injury-in-a-large-animal-model(ab917c99-7e7f-4fa1-8d1e-40511ca9abd3).htmlMethods to protect against radiation-induced lung injury (RILI) will facilitate the development of more effective radio-therapeutic protocols for lung cancer and may provide the means to protect the wider population in the event of a deliberate or accidental nuclear or radiological event. We hypothesised that supplementing lipid membranes through nebulization of synthetic lamellar lipids would mitigate RILI. Following pre-treatment with either nebulised lamellar lipids or saline, anaesthetised sheep were prescribed fractionated radiotherapy (30 Gray (Gy) total dose in five 6 Gy fractions at 3–4 days intervals) to a defined unilateral lung volume. Gross pathology in radio-exposed lung 37 days after the first radiation treatment was consistent between treatment groups and consisted of deep red congestion evident on the pleural surface and firmness on palpation. Consistent histopathological features in radio-exposed lung were subpleural, periarteriolar and peribronchial intra-alveolar oedema, alveolar fibrosis, interstitial pneumonia and type II pneumocyte hyperplasia. The synthetic lamellar lipids abrogated radiation-induced alveolar fibrosis and reduced alpha-smooth muscle actin (ASMA) expression in radio-exposed lung compared to saline treated sheep. Administration of synthetic lamellar lipids was also associated with an increased number of cells expressing dendritic cell-lysosomal associated membrane protein throughout the lung.This work was supported by Grant MRC/CIC3/025 awarded to D.C., J.L., J.M., G.M. & J.P. The authors wish to acknowledge the assistance of Dryden Animal Services in the conduct of this work, and the assistance of Dr Helen Brown in relation to experimental design and statistical analysis. The authors are grateful to Lamellar Biomedical Ltd., Strathclyde Business Park, Bellshill, Scotland, United Kingdom, for the supply of LAMELLASOME™ used in this research.8pubpubArticle no: 1331

Modelling of JET hybrid scenarios with GLF23 transport model: E × B shear stabilization of anomalous transport

The E&amp;nbsp;×&amp;nbsp;B shear stabilization of anomalous transport in JET hybrid discharges is studied via self-consistent predictive modelling of electron and ion temperature, ion density and toroidal rotation velocity performed with the GLF23 model. The E&amp;nbsp;×&amp;nbsp;B shear stabilization factor (parameter α E in the GLF23 model) is adjusted to predict accurately the four simulated quantities under different experimental conditions, and the uncertainty in α E determined by 15% deviation between simulated and measured quantities is estimated. A correlation of α E with toroidal rotation velocity and E&amp;nbsp;×&amp;nbsp;B shearing rate is found in the low density plasmas, suggesting that the turbulence quench rule may be more complicated than assumed in the GLF23 model with constant α E . For the selected discharges the best predictive accuracy is obtained by using weak/no E&amp;nbsp;×&amp;nbsp;B shear stabilization (i.e. α E&amp;nbsp;≈&amp;nbsp;0) at low toroidal angular frequency (Ω&amp;nbsp;&amp;lt;&amp;nbsp;60&amp;nbsp;krad&amp;nbsp;s −1 ), even in the scenarios with the current overshoot, and α E&amp;nbsp;=&amp;nbsp;0.9 at high frequency (Ω&amp;nbsp;&amp;gt;&amp;nbsp;100&amp;nbsp;krad&amp;nbsp;s −1 ). Interestingly, a weak E&amp;nbsp;×&amp;nbsp; B shear stabilization of anomalous transport is found in the medium density strongly rotating discharge. An importance of linear β e stabilization in this discharge is estimated and compared to the low density discharge with equally high β e . The toroidal rotation velocity is well predicted here by assuming that the momentum diffusion coefficient is a fraction of thermal ion diffusivity. Taking into account the α E and Prandtl number with their uncertainties determined in the modelling of JET hybrid discharges, the performance of ITER hybrid scenario with optimized heat mix (33&amp;nbsp;MW of NBI and 20&amp;nbsp;MW of ECCD) is estimated showing the importance of toroidal rotation for achieving Q &amp;nbsp;&amp;gt;&amp;nbsp;5