Photodynamic Stromal Depletion in Pancreatic Ductal Adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid malignancies, with a five-year survival of less than 10%. The resistance of the disease and the associated lack of therapeutic response is attributed primarily to its dense, fibrotic stroma, which acts as a barrier to drug perfusion and permits tumour survival and invasion. As clinical trials of chemotherapy (CT), radiotherapy (RT), and targeted agents have not been successful, improving the survival rate in unresectable PDAC remains an urgent clinical need. Photodynamic stromal depletion (PSD) is a recent approach that uses visible or near-infrared light to destroy the desmoplastic tissue. Preclinical evidence suggests this can resensitise tumour cells to subsequent therapies whilst averting the tumorigenic effects of tumour–stromal cell interactions. So far, the pre-clinical studies have suggested that PDT can successfully mediate the destruction of various stromal elements without increasing the aggressiveness of the tumour. However, the complexity of this interplay, including the combined tumour promoting and suppressing effects, poses unknowns for the clinical application of photodynamic stromal depletion in PDAC

Intercalibration of the barrel electromagnetic calorimeter of the CMS experiment at start-up

Calibration of the relative response of the individual channels of the barrel electromagnetic calorimeter of the CMS detector was accomplished, before installation, with cosmic ray muons and test beams. One fourth of the calorimeter was exposed to a beam of high energy electrons and the relative calibration of the channels, the intercalibration, was found to be reproducible to a precision of about 0.3%. Additionally, data were collected with cosmic rays for the entire ECAL barrel during the commissioning phase. By comparing the intercalibration constants obtained with the electron beam data with those from the cosmic ray data, it is demonstrated that the latter provide an intercalibration precision of 1.5% over most of the barrel ECAL. The best intercalibration precision is expected to come from the analysis of events collected in situ during the LHC operation. Using data collected with both electrons and pion beams, several aspects of the intercalibration procedures based on electrons or neutral pions were investigated

Measurement and modelling of the properties of cohesive sediment deposits

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Measurement and modelling of the properties of cohesive sediment deposits

Research studies undertaken as part of the "Bed Dynamics" Task D of the EC funded COSINUS project are described. The studies undertaken involve the reformulation of sediment exchange equations, in situ field measurements of bed strength, laboratory settling column experiments, bed consolidation modelling, the development of a model of bed dynamics based on generalised Biot theory and the testing of an integrated erosion/entrainment model against laboratory experiments. The results of the various studies are synthesized and overall conclusions drawn

Daily bathymetric surveys document how stratigraphy is built and its extreme incompleteness in submarine channels

Turbidity currents are powerful flows of sediment that pose a hazard to critical seafloor infrastructure and transport globally important amounts of sediment to the deep sea. Due to challenges of direct monitoring, we typically rely on their deposits to reconstruct past turbidity currents. Understanding these flows is complicated because successive flows can rework or erase previous deposits. Hence, depositional environments dominated by turbidity currents, such as submarine channels, only partially record their deposits. But precisely how incomplete these deposits are, is unclear. Here we use the most extensive repeat bathymetric mapping yet of any turbidity current system, to reveal the stratigraphic evolution of three submarine channels. We re-analyze 93 daily repeat surveys performed over four months at the Squamish submarine delta, British Columbia in 2011, during which time >100 turbidity currents were monitored. Turbidity currents deposit and rework sediments into upstream-migrating bedforms, ensuring low rates of preservation (median 11%), even on the terminal lobes. Large delta-lip collapses (up to 150,000 m3) are relatively well preserved, however, due to their rapidly emplaced volumes, which shield underlying channel deposits from erosion over the surveyed timescale. The biggest gaps in the depositional record relate to infrequent powerful flows that cause significant erosion, particularly at the channel-lobe transition zone where no deposits during our monitoring period are preserved. Our analysis of repeat surveys demonstrates how incomplete the stratigraphy of submarine channels can be, even over just 4 months, and provides a new approach to better understand how the stratigraphic record is built and preserved in a wider range of marine settings

Efficient preservation of young terrestrial organic carbon in sandy turbidity-current deposits

Abstract Burial of terrestrial biospheric particulate organic carbon in marine sediments removes CO2 from the atmosphere, regulating climate over geologic time scales. Rivers deliver terrestrial organic carbon to the sea, while turbidity currents transport river sediment further offshore. Previous studies have suggested that most organic carbon resides in muddy marine sediment. However, turbidity currents can carry a significant component of coarser sediment, which is commonly assumed to be organic carbon poor. Here, using data from a Canadian fjord, we show that young woody debris can be rapidly buried in sandy layers of turbidity current deposits (turbidites). These layers have organic carbon contents 10× higher than the overlying mud layer, and overall, woody debris makes up &amp;gt;70% of the organic carbon preserved in the deposits. Burial of woody debris in sands overlain by mud caps reduces their exposure to oxygen, increasing organic carbon burial efficiency. Sandy turbidity current channels are common in fjords and the deep sea; hence we suggest that previous global organic carbon burial budgets may have been underestimated.</jats:p

Efficient preservation of young terrestrial organic carbon in sandy turbidity current deposits

Burial of terrestrial biospheric particulate organic carbon in marine sediments removes CO2 from the atmosphere, regulating climate over geologic time scales. Rivers deliver terrestrial organic carbon to the sea, while turbidity currents transport river sediment further offshore. Previous studies have suggested that most organic carbon resides in muddy marine sediment. However, turbidity currents can carry a significant component of coarser sediment, which is commonly assumed to be organic carbon poor. Here, using data from a Canadian fjord, we show that young woody debris can be rapidly buried in sandy layers of turbidity current deposits (turbidites). These layers have organic carbon contents 10× higher than the overlying mud layer, and overall, woody debris makes up >70% of the organic carbon preserved in the deposits. Burial of woody debris in sands overlain by mud caps reduces their exposure to oxygen, increasing organic carbon burial efficiency. Sandy turbidity current channels are common in fjords and the deep sea; hence we suggest that previous global organic carbon burial budgets may have been underestimated