Do early-life exposures explain why more advantaged children get eczema? Findings from the U.K. Millennium Cohort Study

Background: Atopic dermatitis (eczema) in childhood is socially patterned, with higher incidence in more advantaged populations. However, it is unclear what factors explain the social differences. Objectives: To identify early-life risk factors for eczema, and to explore how early-life risk factors explain any differences in eczema. Methods: We estimated odds ratios (ORs) for ever having had eczema by age 5 years in 14 499 children from the U.K. Millennium Cohort Study (MCS), with a focus on maternal, antenatal and early-life risk factors and socioeconomic circumstances (SECs). Risk factors were explored to assess whether they attenuated associations between SECs and eczema. Results: Overall 35·1% of children had ever had eczema by age 5 years. Children of mothers with degree-level qualifications vs. no educational qualifications were more likely to have eczema (OR 1·52, 95% confidence interval 1·31–1·76), and there was a gradient across the socioeconomic spectrum. Maternal atopy, breastfeeding (1–6 weeks and ≥ 6 months), introduction of solids under 4 months or cow's milk under 9 months, antibiotic exposure in the first year of life and grime exposure were associated with an increased odds of having eczema. Female sex, Pakistani and Bangladeshi ethnicity, smoking during pregnancy, exposure to environmental tobacco smoke and having more siblings were associated with reduced odds for eczema. Controlling for maternal, antenatal and early-life characteristics (particularly maternal smoking during pregnancy, breastfeeding and number of siblings) reduced the OR for eczema to 1·26 (95% confidence interval 1·03–1·50) in the group with the highest educational qualifications compared with the least. Conclusions: In a representative U.K. child cohort, eczema was more common in more advantaged children. This was explained partially by early-life factors including not smoking during pregnancy, breastfeeding and having fewer siblings

Experiences, causes, and measures to tackle institutional incongruence and informal economic activity in South-East Europe

To explain the prevalence and persistence of informal economic activity globally, scholars have recently advanced an institutional incongruence perspective. Institutional incongruence exists where there is a misalignment between what is considered legitimate by a society’s formal institutions (e.g. its laws and regulations) and its informal institutions (e.g. norms, values and beliefs). Reporting findings from a series of qualitative focus groups in Bulgaria, Croatia and the Former Yugoslav Republic of Macedonia, this paper explores relationships between such institutional incongruence and informal economic activity. In particular, it sheds light on how informality and institutional incongruence are experienced by individuals in South-East Europe. It furthermore provides insights on the causes of such incongruence, and how it can lead to informal economic activity. Finally, it reports on individuals’ perceptions towards different measures to tackle institutional incongruence and informal economic activity, with implications for policy makers in South-East Europe and more widely

The role of science in physical natural hazard assessment : report to the UK Government by the Natural Hazard Working Group

Following the tragic Asian tsunami on 26 December 2004, the Prime Minister asked the Government’s Chief Scientific Adviser, Sir David King, to convene a group of experts (the Natural Hazard Working Group) to advise on the mechanisms that could and should be established for the detection and early warning of global physical natural hazards. 2. The Group was asked to examine physical hazards which have high global or regional impact and for which an appropriate early warning system could be put in place. It was also asked to consider the global natural hazard frameworks currently in place and under development and their effectiveness in using scientific evidence; to consider whether there is an existing appropriate international body to pull together the international science community to advise governments on the systems that need to be put in place, and to advise on research needed to fill current gaps in knowledge. The Group was asked to make recommendations on whether a new body was needed, or whether other arrangements would be more effective

Method for analysing phosphate 18O/16O ratios for waters with high C:P ratios

In this report we outline a method to isolate phosphate as pure Ag3PO4 for waters with high C:P ratios for 18O analysis. This report details a method that can be used to minimise residual organic contamination of the final Ag3PO4, therefore significantly reducing uncertainties in the final interpretation of 18O results. This includes the use of column resins in series to (i) remove the majority of dissolved organic carbon and (ii) isolate/pre-concentrate PO4. This is followed by the use of a modified McLaughlin et al (2004) method for PO4 precipitation, with an additional final hydrogen peroxide clean-up step to remove residual organic matter following precipitation of Ag3PO4. The reagents required for this method are first listed, and then a step-by-step account of the process is outlined. Importantly, it contains adequate detail to be used by other researchers in this field or modified to suit their particular research objectives

The response to high magnetic fields of the vacuum phototriodes for the compact muon solenoid endcap electromagnetic calorimeter

The endcap electromagnetic calorimeter of the Compact Muon Solenoid (CMS) detects particles with the dense fast scintillator lead tungstate (PbWO4). Due to the low light yield of this scintillator photodetectors with internal gain are required. Silicon avalanche photodiodes cannot be used in the endcap region due to the intense neutron flux. Following an extensive R&D programme 26 mm diameter single-stage photomultipliers (vacuum phototriodes) have been chosen as the photodetector in the endcap region. The first 1400 production devices are currently being evaluated following recent tests of a pre-production batch of 500 tubes. Tubes passing our acceptance tests have responses, averaged over the angular acceptance of the endcap calorimeter, corresponding to the range 20 to 55 electrons per MeV deposited in PbWO4. These phototriodes operate, with a typical gain of 10, in magnetic fields up to 4T.PPARC, EC(INTAS-CERN scheme 99-424

Rotating black hole orbit functionals in the frequency domain

In many astrophysical problems, it is important to understand the behavior of functions that come from rotating (Kerr) black hole orbits. It can be particularly useful to work with the frequency domain representation of those functions, in order to bring out their harmonic dependence upon the fundamental orbital frequencies of Kerr black holes. Although, as has recently been shown by W. Schmidt, such a frequency domain representation must exist, the coupled nature of a black hole orbit's $r$ and $\theta$ motions makes it difficult to construct such a representation in practice. Combining Schmidt's description with a clever choice of timelike coordinate suggested by Y. Mino, we have developed a simple procedure that sidesteps this difficulty. One first Fourier expands all quantities using Mino's time coordinate $\lambda$. In particular, the observer's time $t$ is decomposed with $\lambda$. The frequency domain description is then built from the $\lambda$-Fourier expansion and the expansion of $t$. We have found this procedure to be quite simple to implement, and to be applicable to a wide class of functionals. We test the procedure using a simple test function, and then apply it in a particularly interesting case, the Weyl curvature scalar $\psi_4$ used in black hole perturbation theory.Comment: 16 pages, 2 figures. Submitted to Phys Rev D. New version gives a vastly improved algorithm due to Drasco for computing the Fourier transforms. Drasco has been added as an author. Also fixed some references and exterminated a small herd of typos; final published versio

Liquid-Solid Transition of Hard Spheres Under Gravity

We investigate the liquid-solid transition of two dimensional hard spheres in the presence of gravity. We determine the transition temperature and the fraction of particles in the solid regime as a function of temperature via Even-Driven molecular dynamics simulations and compare them with the theoretical predictions. We then examine the configurational statistics of a vibrating bed from the view point of the liquid-solid transition by explicitly determining the transition temperature and the effective temperature, T, of the bed, and present a relation between T and the vibration strength.Comment: 14 total pages, 4 figure

COSMOGRAIL: XVII. Time delays for the quadruply imaged quasar PG 1115+080

Indexación: Scopus.Acknowledgements. The authors would like to thank R. Gredel for his help in setting up the program at the ESO MPIA 2.2 m telescope, and the anonymous referee for his or her comments on this work. This work is supported by the Swiss National Fundation. This research made use of Astropy, a community-developed core Python package for Astronomy (Astropy Collaboration et al. 2013, 2018) and the 2D graphics environment Matplotlib (Hunter 2007). K.R. acknowledge support from PhD fellowship FIB-UV 2015/2016 and Becas de Doctorado Nacional CONICYT 2017 and thanks the LSSTC Data Science Fellowship Program, her time as a Fellow has benefited this work. M.T. acknowledges support by the DFG grant Hi 1495/2-1. G. C.-F. C. acknowledges support from the Ministry of Education in Taiwan via Government Scholarship to Study Abroad (GSSA). D. C.-Y. Chao and S. H. Suyu gratefully acknowledge the support from the Max Planck Society through the Max Planck Research Group for S. H. Suyu. T. A. acknowledges support by the Ministry for the Economy, Development, and Tourism’s Programa Inicativa Científica Milenio through grant IC 12009, awarded to The Millennium Institute of Astrophysics (MAS).We present time-delay estimates for the quadruply imaged quasar PG 1115+080. Our results are based on almost daily observations for seven months at the ESO MPIA 2.2 m telescope at La Silla Observatory, reaching a signal-to-noise ratio of about 1000 per quasar image. In addition, we re-analyze existing light curves from the literature that we complete with an additional three seasons of monitoring with the Mercator telescope at La Palma Observatory. When exploring the possible source of bias we considered the so-called microlensing time delay, a potential source of systematic error so far never directly accounted for in previous time-delay publications. In 15 yr of data on PG 1115+080, we find no strong evidence of microlensing time delay. Therefore not accounting for this effect, our time-delay estimates on the individual data sets are in good agreement with each other and with the literature. Combining the data sets, we obtain the most precise time-delay estimates to date on PG 1115+080, with Δt(AB) = 8.3+1.5 -1.6 days (18.7% precision), Δt(AC) = 9.9+1.1 -1.1 days (11.1%) and Δt(BC) = 18.8+1.6 -1.6 days (8.5%). Turning these time delays into cosmological constraints is done in a companion paper that makes use of ground-based Adaptive Optics (AO) with the Keck telescope. © ESO 2018.https://www.aanda.org/articles/aa/abs/2018/08/aa33287-18/aa33287-18.htm

Radiocarbon Date List X: Baffin Bay, Baffin Island, Iceland, Labrador Sea, and the Northern North Atlantic

Date List X contains an annotated listing of 213 radiocarbon dates determined on samples from marine and terrestrial environments. The marine samples were collected from the East Greenland, Iceland, Spitzbergen, and Norwegian margins, Baffin Bay, and Labrador Sea. The terrestrial samples were collected from Vestfirdir, Iceland and Baffin Island. The samples were submitted by INSTAAR and researchers affiliated with INSTAAR\u27s Micropaleontology Laboratory under the direction of Dr.’s John T. Andrews and Anne E. Jennings. All of the dates from marine sediment cores were determined from either shells or foraminifera (both benthic and planktic). All dates were obtained by the Accelerator Mass Spectrometry (AMS) method. Regions of concentrated marine research include: Baffin Bay, Baffin Island, Labrador Sea, East Greenland fjords, shelf and slope, Denmark Strait, the southwestern and northwestern Iceland shelves, and Vestfirdir, Iceland. The non-marine radiocarbon dates are from peat, wood, plant microfossils, and mollusc. The radiocarbon dates have been used to address a variety of research objectives such as: 1. determining the timing of northern hemisphere high latitude environmental changes including glacier advance and retreat, and 2. assessing the accuracy of a fluctuating reservoir correction. Thus, most of the dates constrain the timing, rate, and interaction of late Quaternary paleoenvironmental fluctuations in sea level, glacier extent, sediment input, and changes in ocean circulation patterns. Where significant, stratigraphic and sample contexts are presented for each core to document the basis for interpretations

Onset of magnetism in B2 transition metals aluminides

Ab initio calculation results for the electronic structure of disordered bcc Fe(x)Al(1-x) (0.4<x<0.75), Co(x)Al(1-x) and Ni(x)Al(1-x) (x=0.4; 0.5; 0.6) alloys near the 1:1 stoichiometry, as well as of the ordered B2 (FeAl, CoAl, NiAl) phases with point defects are presented. The calculations were performed using the coherent potential approximation within the Korringa-Kohn-Rostoker method (KKR-CPA) for the disordered case and the tight-binding linear muffin-tin orbital (TB-LMTO) method for the intermetallic compounds. We studied in particular the onset of magnetism in Fe-Al and Co-Al systems as a function of the defect structure. We found the appearance of large local magnetic moments associated with the transition metal (TM) antisite defect in FeAl and CoAl compounds, in agreement with the experimental findings. Moreover, we found that any vacancies on both sublattices enhance the magnetic moments via reducing the charge transfer to a TM atom. Disordered Fe-Al alloys are ferromagnetically ordered for the whole range of composition studied, whereas Co-Al becomes magnetic only for Co concentration >0.5.Comment: 11 pages with 9 embedded postscript figures, to be published in Phys.Rev.