1. SOLUCIÓN TECNOLÓGICA EN EL USO DEL TRANSPORTE ESPECIAL INTERMUNICIPAL “TUVIAJE”

El Servicio de transporte público intermunicipal constituye una de las fuentes crecientes de la economía, siendo una brecha competitiva en el sector del servicio público, pero también una de las problemáticas que acarrea constantemente con los usuarios en la baja calidad del servicio, baja demanda de vehiculos y los excesivos tiempos de espera en las Terminales de Transporte. Por consiguiente, el Ministerio de Transporte ha detectado la necesidad de mejorar las condiciones de transporte en el fortalecimiento de la malla vial, en el acceso a alternativas legales para el transporte intermunicipal. Debido a estos antecedentes se implementa una solución tecnológica llamada TUViaje, enfocado en brindar un abanico de posibilidades a través de una solución móvil (APP ) para este tipo de transporte apalancado con las empresas de servicio especial. Para el desarrollo de proyecto y su respectivo estudio, se aplica un procedimiento en 5 fases: planeación, requerimientos, diseño, desarrollo y pruebas, según el ciclo metodológico de kanban. Finalmente se realizan pruebas de usabilidad para su compresión, experiencia de usuarios para medir el nivel de optimización de tiempo en relación con la calidad del servicio y el aprovechamiento del sistema entre los usuarios y conductores. Esta solución facilitó el estudio para analizar el comportamiento de los usuarios, conductores y empresas de servicio de transporte especial y la forma de aportar avances tecnológicos al sector de transporte intermunicipal y la innovación con nuevas alternativas que aumenten sus niveles de efectividad

1. SOLUCIÓN TECNOLÓGICA EN EL USO DEL TRANSPORTE ESPECIAL INTERMUNICIPAL “TUVIAJE”

El Servicio de transporte público intermunicipal constituye una de las fuentes crecientes de la economía, siendo una brecha competitiva en el sector del servicio público, pero también una de las problemáticas que acarrea constantemente con los usuarios en la baja calidad del servicio, baja demanda de vehiculos y los excesivos tiempos de espera en las Terminales de Transporte. Por consiguiente, el Ministerio de Transporte ha detectado la necesidad de mejorar las condiciones de transporte en el fortalecimiento de la malla vial, en el acceso a alternativas legales para el transporte intermunicipal. Debido a estos antecedentes se implementa una solución tecnológica llamada TUViaje, enfocado en brindar un abanico de posibilidades a través de una solución móvil (APP ) para este tipo de transporte apalancado con las empresas de servicio especial. Para el desarrollo de proyecto y su respectivo estudio, se aplica un procedimiento en 5 fases: planeación, requerimientos, diseño, desarrollo y pruebas, según el ciclo metodológico de kanban. Finalmente se realizan pruebas de usabilidad para su compresión, experiencia de usuarios para medir el nivel de optimización de tiempo en relación con la calidad del servicio y el aprovechamiento del sistema entre los usuarios y conductores. Esta solución facilitó el estudio para analizar el comportamiento de los usuarios, conductores y empresas de servicio de transporte especial y la forma de aportar avances tecnológicos al sector de transporte intermunicipal y la innovación con nuevas alternativas que aumenten sus niveles de efectividad

Open Cosmic Strings in Black Hole Space-Times

We construct open cosmic string solutions in Schwarzschild black hole and non-dilatonic black p-brane backgrounds. These strings can be thought to stretch between two D-branes or between a D-brane and the horizon in curved space-time. We study small fluctuations around these solutions and discuss their basic properties.Comment: 11 pages, REVTex, 5 figures, a reference adde

First and second order optimality conditions for optimal control problems of state constrained integral equations

This paper deals with optimal control problems of integral equations, with initial-final and running state constraints. The order of a running state constraint is defined in the setting of integral dynamics, and we work here with constraints of arbitrary high orders. First and second-order necessary conditions of optimality are obtained, as well as second-order sufficient conditions

Phase nucleation in curved space

Theoretical Physic

Guillain-Barré syndrome : causes, immunopathogenic mechanisms and treatment

Introduction: Guillain-Barr\ue9 syndrome is a rare disease representing the most frequent cause of acute flaccid symmetrical weakness of the limbs and areflexia usually reaching its peak within a month. The etiology and pathogenesis remain largely enigmatic and the syndrome results in death or severe disability in 9\u201317% of cases despite immunotherapy. Areas covered: In terms of etiology, Guillain-Barr\ue9 syndrome is linked to Campylobacter infection but less than 0.1% of infections result in the syndrome. In terms of pathogenesis, activated macrophages and T cells and serum antibodies against gangliosides are observed but their significance is unclear. Expert commentary: Guillain-Barr\ue9 syndrome is a heterogeneous condition with numerous subtypes and recent data point towards the role of ganglioside epitopes by immunohistochemical methods. Ultimately, the syndrome results from a permissive genetic background on which environmental factors, including infections, vaccination and the influence of aging, lead to disease

On the covariant quantization of tensionless bosonic strings in AdS spacetime

The covariant quantization of the tensionless free bosonic (open and closed) strings in AdS spaces is obtained. This is done by representing the AdS space as an hyperboloid in a flat auxiliary space and by studying the resulting string constrained hamiltonian system in the tensionless limit. It turns out that the constraint algebra simplifies in the tensionless case in such a way that the closed BRST quantization can be formulated and the theory admits then an explicit covariant quantization scheme. This holds for any value of the dimension of the AdS space.Comment: 1+16 pages; v4 two clarifications adde

A Model for the Development of the Rhizobial and Arbuscular Mycorrhizal Symbioses in Legumes and Its Use to Understand the Roles of Ethylene in the Establishment of these two Symbioses

We propose a model depicting the development of nodulation and arbuscular mycorrhizae. Both processes are dissected into many steps, using Pisum sativum L. nodulation mutants as a guideline. For nodulation, we distinguish two main developmental programs, one epidermal and one cortical. Whereas Nod factors alone affect the cortical program, bacteria are required to trigger the epidermal events. We propose that the two programs of the rhizobial symbiosis evolved separately and that, over time, they came to function together. The distinction between these two programs does not exist for arbuscular mycorrhizae development despite events occurring in both root tissues. Mutations that affect both symbioses are restricted to the epidermal program. We propose here sites of action and potential roles for ethylene during the formation of the two symbioses with a specific hypothesis for nodule organogenesis. Assuming the epidermis does not make ethylene, the microsymbionts probably first encounter a regulatory level of ethylene at the epidermis–outermost cortical cell layer interface. Depending on the hormone concentrations there, infection will either progress or be blocked. In the former case, ethylene affects the cortex cytoskeleton, allowing reorganization that facilitates infection; in the latter case, ethylene acts on several enzymes that interfere with infection thread growth, causing it to abort. Throughout this review, the difficulty of generalizing the roles of ethylene is emphasized and numerous examples are given to demonstrate the diversity that exists in plants

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types