1,158 research outputs found
A rank based social norms model of how people judge their levels of drunkenness whilst intoxicated
Background:
A rank based social norms model predicts that drinkers’ judgements about their drinking will be based on the rank of their breath alcohol level amongst that of others in the immediate environment, rather than their actual breath alcohol level, with lower relative rank associated with greater feelings of safety. This study tested this hypothesis and examined how people judge their levels of drunkenness and the health consequences of their drinking whilst they are intoxicated in social drinking environments.
Methods:
Breath alcohol testing of 1,862 people (mean age = 26.96 years; 61.86 % male) in drinking environments. A subset (N = 400) also answered four questions asking about their perceptions of their drunkenness and the health consequences of their drinking (plus background measures).
Results:
Perceptions of drunkenness and the health consequences of drinking were regressed on: (a) breath alcohol level, (b) the rank of the breath alcohol level amongst that of others in the same environment, and (c) covariates. Only rank of breath alcohol level predicted perceptions: How drunk they felt (b 3.78, 95Â % CI 1.69 5.87), how extreme they regarded their drinking that night (b 3.7, 95Â % CI 1.3 6.20), how at risk their long-term health was due to their current level of drinking (b 4.1, 95Â % CI 0.2 8.0) and how likely they felt they would experience liver cirrhosis (b 4.8. 95Â % CI 0.7 8.8). People were more influenced by more sober others than by more drunk others.
Conclusion:
Whilst intoxicated and in drinking environments, people base judgements regarding their drinking on how their level of intoxication ranks relative to that of others of the same gender around them, not on their actual levels of intoxication. Thus, when in the company of others who are intoxicated, drinkers were found to be more likely to underestimate their own level of drinking, drunkenness and associated risks. The implications of these results, for example that increasing the numbers of sober people in night time environments could improve subjective assessments of drunkenness, are discussed
CHANDRA Observations of X-ray Jet Structure on kpc to Mpc Scales
With its exquisite spatial resolution of better than 0.5 arcsecond, the
Chandra observatory is uniquely capable of resolving and studying the spatial
structure of extragalactic X-ray jets on scales of a few to a few hundred
kilo-parsec. Our analyses of four recent Chandra images of quasar jets
interpret the X-ray emission as inverse Compton scattering of high energy
electrons on the cosmic microwave background. We infer that these jets are in
bulk relativistic motion, carrying kinetic powers upwards of 10^46 ergs/s to
distances of hundreds of kpc, with very high efficiency.Comment: 4 pages, 3 figures, to be published in the proceedings of the Bologna
jet workshop, "The Physics of Relativistic Jets in the CHANDRA and XMM Era.
The defect chemistry of UO2±x from atomistic simulations
Control of the defect chemistry in UO2±x is important for manipulating nuclear fuel properties and fuel performance. For example, the uranium vacancy concentration is critical for fission gas release and sintering, while all oxygen and uranium defects are known to strongly influence thermal conductivity. Here the point defect concentrations in thermal equilibrium are predicted using defect energies from density functional theory (DFT) and vibrational entropies calculated using empirical potentials. Electrons and holes have been treated in a similar fashion to other charged defects allowing for structural relaxation around the localized electronic defects. Predictions are made for the defect concentrations and non-stoichiometry of UO2±x as a function of oxygen partial pressure and temperature. If vibrational entropy is omitted, oxygen interstitials are predicted to be the dominant mechanism of excess oxygen accommodation over only a small temperature range (1265 K–1350 K), in contrast to experimental observation. Conversely, if vibrational entropy is included oxygen interstitials dominate from 1165 K to 1680 K (Busker potential) or from 1275 K to 1630 K (CRG potential). Below these temperature ranges excess oxygen is predicted to be accommodated by uranium vacancies, while above them the system is hypo-stoichiometric with oxygen deficiency accommodated by oxygen vacancies. Our results are discussed in the context of oxygen clustering, formation of U4O9, and issues for fuel behavior. In particular, the variation of the uranium vacancy concentrations as a function of temperature and oxygen partial pressure will underpin future studies into fission gas diffusivity and broaden the understanding of UO2±x sintering
Hecke algebras of finite type are cellular
Let \cH be the one-parameter Hecke algebra associated to a finite Weyl
group , defined over a ground ring in which ``bad'' primes for are
invertible. Using deep properties of the Kazhdan--Lusztig basis of \cH and
Lusztig's \ba-function, we show that \cH has a natural cellular structure
in the sense of Graham and Lehrer. Thus, we obtain a general theory of ``Specht
modules'' for Hecke algebras of finite type. Previously, a general cellular
structure was only known to exist in types and .Comment: 14 pages; added reference
3D ground model development for an active landslide in Lias mudrocks using geophysical, remote sensing and geotechnical methods
A ground model of an active and complex landslide system in instability prone Lias mudrocks of North Yorkshire, UK is developed through an integrated approach, utilising geophysical, geotechnical and remote sensing investigative methods. Surface geomorphology is mapped and interpreted using immersive 3D visualisation software to interpret airborne light detection and ranging data and aerial photographs. Subsurface structure is determined by core logging and 3D electrical resistivity tomography (ERT), which is deployed at two scales of resolution to provide a means of volumetrically characterising the subsurface expression of both site scale (tens of metres) geological structure, and finer (metre to sub-metre) scale earth-flow related structures. Petrophysical analysis of the borehole core samples is used to develop relationships between the electrical and physical formation properties, to aid calibration and interpretation of 3D ERT images. Results of the landslide investigation reveal that an integrated approach centred on volumetric geophysical imaging successfully achieves a detailed understanding of structure and lithology of a complex landslide system, which cannot be achieved through the use of remotely sensed data or discrete intrusive sampling alone
Mass spectrometry based metabolomics comparison of liver grafts from donors after circulatory death (DCD) and donors after brain death (DBD) used in human orthotopic liver transplantation
Use of marginal liver grafts, especially those from donors after circulatory death (DCD), has been considered as a solution to organ shortage. Inferior outcomes have been attributed to donor warm ischaemic damage in these DCD organs. Here we sought to profile the metabolic mechanisms underpinning donor warm ischaemia. Non-targeted Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry metabolomics was applied to biopsies of liver grafts from donors after brain death (DBD; n = 27) and DCD (n = 10), both during static cold storage (T1) as well as post-reperfusion (T2). Furthermore 6 biopsies from DBD donors prior to the organ donation (T0) were also profiled. Considering DBD and DCD together, significant metabolic differences were discovered between T1 and T2 (688 peaks) that were primarily related to amino acid metabolism, meanwhile T0 biopsies grouped together with T2, denoting the distinctively different metabolic activity of the perfused state. Major metabolic differences were discovered between DCD and DBD during cold-phase (T1) primarily related to glucose, tryptophan and kynurenine metabolism, and in the post-reperfusion phase (T2) related to amino acid and glutathione metabolism. We propose tryptophan/kynurenine and S-adenosylmethionine as possible biomarkers for the previously established higher graft failure of DCD livers, and conclude that the associated pathways should be targeted in more exhaustive and quantitative investigations
Observable Effects of Scalar Fields and Varying Constants
We show by using the method of matched asymptotic expansions that a
sufficient condition can be derived which determines when a local experiment
will detect the cosmological variation of a scalar field which is driving the
spacetime variation of a supposed constant of Nature. We extend our earlier
analyses of this problem by including the possibility that the local region is
undergoing collapse inside a virialised structure, like a galaxy or galaxy
cluster. We show by direct calculation that the sufficient condition is met to
high precision in our own local region and we can therefore legitimately use
local observations to place constraints upon the variation of "constants" of
Nature on cosmological scales.Comment: Invited Festscrift Articl
Quintessence and variation of the fine structure constant in the CMBR
We study dependence of the CMB temperature anisotropy spectrum on the value
of the fine structure constant and the equation of state of the dark
energy component of the total density of the universe. We find that bounds
imposed on the variation of from the analysis of currently available
CMB data sets can be significantly relaxed if one also allows for a change in
the equation of state.Comment: 5 pages, 3 figures. Several references added and a few minor typos
corrected in the revised versio
A Laser Frequency Comb System for Absolute Calibration of the VTT Echelle Spectrograph
A wavelength calibration system based on a laser frequency comb (LFC) was
developed in a co-operation between the Kiepenheuer-Institut f\"ur
Sonnenphysik, Freiburg, Germany and the Max-Planck-Institut f\"ur Quantenoptik,
Garching, Germany for permanent installation at the German Vacuum Tower
Telescope (VTT) on Tenerife, Canary Islands. The system was installed
successfully in October 2011. By simultaneously recording the spectra from the
Sun and the LFC, for each exposure a calibration curve can be derived from the
known frequencies of the comb modes that is suitable for absolute calibration
at the meters per second level. We briefly summarize some topics in solar
physics that benefit from absolute spectroscopy and point out the advantages of
LFC compared to traditional calibration techniques. We also sketch the basic
setup of the VTT calibration system and its integration with the existing
echelle spectrograph.Comment: 9 pages, 2 figures; Solar Physics 277 (2012
The serum proteome of Atlantic salmon, Salmo salar, during pancreas disease (PD) following infection with salmonid alphavirus subtype 3 (SAV3)
Salmonid alphavirus is the aetological agent of pancreas disease (PD) in marine Atlantic salmon, Salmo salar, and rainbow trout, Oncorhynchus mykiss, with most outbreaks in Norway caused by SAV subtype 3 (SAV3). This atypical alphavirus is transmitted horizontally causing a significant economic impact on the aquaculture industry. This histopathological and proteomic study, using an established cohabitational experimental model, investigated the correlation between tissue damage during PD and a number of serum proteins associated with these pathologies in Atlantic salmon. The proteins were identified by two-dimensional electrophoresis, trypsin digest and peptide MS/MS fingerprinting. A number of humoral components of immunity which may act as biomarkers of the disease were also identified. For example, creatine kinase, enolase and malate dehydrogenase serum concentrations were shown to correlate with pathology during PD. In contrast, hemopexin, transferrin, and apolipoprotein, amongst others, altered during later stages of the disease and did not correlate with tissue pathologies. This approach has given new insight into not only PD but also fish disease as a whole, by characterisation of the protein response to infection, through pathological processes to tissue recovery.
Biological significance:
Salmonid alphavirus causes pancreas disease (PD) in Atlantic salmon, Salmo salar, and has a major economic impact on the aquaculture industry. A proteomic investigation of the change to the serum proteome during PD has been made with an established experimental model of the disease. Serum proteins were identified by two-dimensional electrophoresis, trypsin digest and peptide MS/MS fingerprinting with 72 protein spots being shown to alter significantly over the 12 week period of the infection. The concentrations of certain proteins in serum such as creatine kinase, enolase and malate dehydrogenase were shown to correlate with tissue pathology while other proteins such as hemopexin, transferrin, and apolipoprotein, altered in concentration during later stages of the disease and did not correlate with tissue pathologies. The protein response to infection may be used to monitor disease progression and enhance understanding of the pathology of PD
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